GEN-MKT-18-7897-A
May 13, 2016 | Blogs, Food / Beverage | 0 comments
Recent regulations on food analysis require screening for pesticides using confirmatory techniques, such as GC-MS and LC-MS/MS. More than 1000 pesticides are used worldwide and, along with their metabolites and degradation products, are present in food. There is a demand for powerful and rapid analytical methods that can identify pesticides with high confidence in a broad range of food matrices and quantify at low concentrations with good accuracy and reproducibility. Challenges for pesticide residue laboratories at the moment are the request to test for more compounds, in a wider range of samples, all without sacrificing data quality. The QTRAP® 6500 LC-MS/MS system uses multi-component IonDrive™ technology to:
In addition, the QTRAP 6500 system uses the patented and proven Linear Accelerator™ trap technology to:
A new method for the quantitation and identification of hundreds of pesticides in food samples was developed and successfully applied to the analysis of complex food samples using the QTRAP 6500 system. Results are compared to QTRAP 5500 data. The increased sensitivity was used to extensively dilute sample extracts to eliminate ion suppression caused by matrix components and the extended linear dynamic range allowed quantifying more pesticides across a wider range of chemical properties. QTRAP scanning was used to investigate the presence of matrix components and to identify targets with high confidence through library searching. Quantitative and qualitative results were generated using MultiQuant™ and LibraryView™ Software.
See the results in the full article by downloading the Food Compendium.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
At SCIEX, innovation doesn’t stop at instruments; it extends to how you interact with your LC-MS/MS or CE systems every day. That’s why we’re excited to introduce the SCIEX Now spring 2026 improvements: a set of meaningful enhancements shaped directly by your feedback.
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