GEN-MKT-18-7897-A
Jul 17, 2015 | Blogs, Food / Beverage | 0 comments
Spoiler Alert – How to Save Time Testing for Bacteria in Beer?
Nothing ruins a batch of beer worse than bacteria, specifically Pediococcus and Lactobacillus. Too much of these hop resistant genes can get carried away causing spoilage and sour beer. It is why breweries put every batch of beer through a quality control check before it is sent out to the consumer.
However, sometimes bad batches make it out the door because wild yeasts can be too small to detect using conventional microbial techniques. To ensure accuracy and efficacy, however, the SCIEX food and beverage scientists are putting many a beer to the test using capillary electrophoresis (CE) multiplex PCR (XP-PCR). This process has been proven to simultaneously identify six major genera of beer spoilage bacteria and yeast along with their potential to spoil beer by detecting five hop resistant markers within 24 hours of sampling.
Beer Testing Goes MolecularThe benefit to lab scientists is molecular testing delivers fast results and high-resolution separation. According to Handy Yowanto, Senior Product Manager, SCIEX Genetic Analysis Product, “If you want to skip the guesswork, molecular techniques are the answer. They detect different types of microbes in tank cleaning, brewing process and final product quality check (QC).”
The Message Is This:If you are using conventional microbial culturing techniques along with dye sequencing, you may be missing some bacteria. The reason being is these methods cannot detect hop resistant genes that allow unculturable or slow-growing microorganisms to flourish. Don’t let your beer fall flat. Bacteria can be introduced at any stage of the brewing process, but you can learn how to attack the problem by detecting hop resistant genes.Read the Full Report >
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
At SCIEX, innovation doesn’t stop at instruments; it extends to how you interact with your LC-MS/MS or CE systems every day. That’s why we’re excited to introduce the SCIEX Now spring 2026 improvements: a set of meaningful enhancements shaped directly by your feedback.
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