GEN-MKT-18-7897-A
Nov 24, 2015 | Blogs, Food / Beverage | 0 comments
Truth – the first turkey I ever cooked was still frozen when it hit our plates. I couldn’t figure out why that thing was taking so long to roast. Then it hit me. I forgot to defrost the bird. If I recall correctly, even the giblets were still in it. It was ten p.m. when I broke the news to my guests that the turkey was not happening. A pizza was ordered, and everyone breathed a sigh of relief that they would not be suffering from a bout of food poisoning.
These days I defrost the turkey a few days ahead of the holiday. I know a turkey is done when it reaches 180 degrees Fahrenheit in the thigh and 165 degrees in the breast or stuffing. However, what I do not know is whether pesticides are lurking in the yummy deliciousness. As a scientist, I think about these things all the time. It is a common work hazard. For instance, the mass produced turkeys you find in the grocery store are injected with veterinary medicines to prevent illnesses and accelerate growth. No matter how long you cook the bird, those pesticides can remain in the meat even though a required withdrawal period takes place before slaughter.
Thankfully, manufacturers entrust labs to test routinely food for antibiotics using technology like the SCIEX QTRAP® which can detect antibiotics at trace levels. Common drugs including Oxytetracycline, Tetracycline and Chlortetracycline, can be detected at low levels in less than three minutes. What is more is that our High-Resolution MS library contains more than 240 veterinary drug compounds to assist labs in the analysis of animal tissue that makes me feel much better about eating my turkey.
I understand not everyone wants a mass spectrometer as their centrepiece on Thanksgiving Day, which is why you can be grateful the testing happens well in advance of the bird purchase. However, if you are concerned about antibiotics in your turkey then check with local farmers to see how they raise their birds.
USDA Turkey FACTS
Finding the right information shouldn’t slow you down. Whether you’re troubleshooting your mass spec, learning something new, or optimizing performance, access to the right resources at the right moment makes all the difference.
As an analytical strategy, middle-down mass spectrometry (MS) workflows characterize biotherapeutic proteins by analyzing large, digested protein fragments or defined subunits, rather than fully intact proteins (top-down) or digested peptides (bottom-up). A middle-down strategy combines the strengths of top-down and bottom-up approaches by delivering high sequence coverage and structural specificity while maintaining relatively simple sample preparation. In practice, middle-down analysis enables accurate mass measurement, rapid sequence confirmation, and localization of key post-translational modifications (PTMs) on protein subunits that are directly relevant to product quality.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
Posted by
You must be logged in to post a comment.
Share this post with your network