GEN-MKT-18-7897-A
Feb 1, 2016 | Blogs, Food / Beverage | 0 comments
In this poster talk André Schreiber, Applications and Product Manager for Food and Environmental Markets at SCIEX guides you through a new method developed in conjunction with Association of Analytical Communities (AOAC). The method is designed to better detect a harmful substance that the infant formula and milk industry are under threat from – Sodium Fluoroacetate, otherwise known as Compound 1080 or Monofluoroacetate.
Video Transcription (view video below)Ok ladies and gentleman, we’re here at the RAFA conference in Prague in 2015, and I would like to give you just a little overview of the poster presentation I am presenting here. It’s a method we developed very recently on our very new QTRAP® 6500+ system. It is a method addressing a major need and concern right now in the infant formula industry and milk industry.
Pesticide Contamination And Food Safety ConcernsEarlier this year, New Zealand companies were threatened that somebody would poison infant formula with a compound called pesticide 1080, or otherwise known as monofluoroacetate. Of course, we have major concerns about food safety here so we started to develop a method to monitor this compound in infant formula samples and milk samples.
We adapted a method which was published using the AOAC community, using LC-MS/MS and we used our latest mass spectrometer, the 6500+ system to make sure we can detect this compound at very low levels.
Monofluoroacetate Identification MethodNormal phase chromatography was used with a very simple extraction procedure to quickly extract the compound from milk and infant formula samples; remove a couple of interferences and you can see here on the chromatograms excellent sensitivity and very good selectivity.
This method allows us to detect compound pesticide 1080 as low as 1 part per billion in milk and infant formula samples.
This was a quick method development, and we are now in the process of implementing it in the AOAC community.
To explore this topic further, you can download the full Detection of Pesticide 1080 in Milk and Infant Formula Poster.Download Complete Pesticide Infokit >
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
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