GEN-MKT-18-7897-A
Jul 26, 2016 | Blogs, Environmental / Industrial | 0 comments
The United States Environmental Protection Agency (EPA), under the 1996 Safe Drinking Water Act (SDWA), requires a new list of no more than 30 unregulated contaminants to be monitored by public drinking water systems. Known as the Unregulated Contaminant Monitoring Rule (UCMR), a new list is published every five years. The last rule, UCMR3, was published May 2, 2012, and is the focus of the following application note, “Analysis of Perfluoroalkyl (PFFA) Acids Specified under the UCMR3 Using the QTRAP® 6500 LC-MS/MS system,” which can be found in the Food and Environmental Compendium.
OverviewUsing the guidelines laid out by EPA Method 537, “A Determination of Selected Perfluoroalkyl Acids in Drinking Water by Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS),” this application note describes the performance of the QTRAP 6500. Within the scope of EPA 537, there are 14 PFAAs. Six are specified under the UCMR3 monitoring list.
ProcessSample preparation and data processing were carried out according to EPA Method 537 without deviation unless specifically noted. The analysis was carried out using the QTRAP 6500 coupled with the Agilent 1260 HPLC with an Eksigent ULC 100 HTC-xt autosampler. Quantitation using MultiQuant ™ 3.0.
ConclusionThe lower the detection, the harder the QTRAP 6500 works for you as it easily meets the UCMR3 reporting limits. See what more it can do when you download the compendium. Download the compendium >
Regulated laboratories are evolving faster than ever. New analytical modalities, higher sample throughput, increasing regulatory scrutiny, and leaner teams are reshaping how work gets done. At the same time, expectations for data integrity, standardization, and operational efficiency continue to increase complexity and/or scope. In this environment, LC-MS software is no longer simply an instrument control platform—it has become a critical part of a laboratory’s quality management system. The question is no longer whether your lab has changed, but whether your software has evolved to support the way regulated labs operate today, and if they are ready and able to meet the demands, they will face tomorrow.
Analyst software has long been a trusted foundation in regulated LC-MS laboratories—and for many, it still performs reliably today. But regulated environments are evolving faster than ever. As labs transition to Windows 11, strengthen cybersecurity policies, modernize IT infrastructure, and prepare for future compliance expectations, software decisions are no longer just about what works today—they’re about managing tomorrow’s risk. Analyst will not be supported on Windows 11. While some labs may continue operating in unsupported environments temporarily, the bigger question is: when that risk becomes reality, will your lab be reacting under pressure—or executing a planned mitigation strategy with confidence?
As regulatory scrutiny increases and detection requirements tighten, laboratories are facing a new question: How can TFA be measured reliably, sensitively, and at scale?
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