GEN-MKT-18-7897-A
Feb 7, 2017 | Biopharma, Blogs | 0 comments
Learning a new mass spec system can be a daunting task. Aside from the opportunity costs of training new users, you might face the hassle of downtime, and the wait to get expert help when needed. The X500B QTOF system puts a new spin on biologics characterization workflows because it is so easy to learn and operate that you can be up and running much faster than you expect. Powerful new software tools dramatically streamline method development and data processing, to enable everyone in your lab to get expert results. It’s fast because it’s easy, even for new users.Intact Mass Analysis: Rapid Answers with ConfidenceNew BioPharmaView™ Software 2.0 combines perfectly with the X500B QTOF system, to put powerful data processing tools for visualization and comparisons at your fingertips. You only need to provide protein sequence and potential modification information, since BioPharmaView Software automates intact protein deconvolution in seconds. In BioPharmaView software you’re able to:
Discover how automated, and lightning fast drug-antibody ratio (DAR) calculations in BioPharmaView Software allow for easy sample comparison, so you can spend less time on manual calculations and more time on visualizing drug load. Add to that easy one-click batch processing and automated ratio calculations for post-translational modification analysis. You’ll see how straightforward it is to rapidly identify and visualize differences between samples to make direct comparisons in either the raw MS spectra or deconvoluted protein results.Peptide Mapping: Unbiased Comprehensive AnalysisSCIEX OS operating software built into the X500B QTOF system makes comprehensive peptide mapping easier with new workflows: simplified acquisition and streamlined peptide mapping analysis ensure everyone can get great results with just a few clicks.The X500B system supports traditional Information or Data-Dependent Acquisition (IDA or DDA) methods, as well as proprietary SWATH® Information Independent Acquisition (IDA) for comprehensive identification of even low abundance peptides and post-translational modifications. SWATH Acquisition employs an unbiased acquisition strategy, where every precursor is targeted for MS/MS analysis, so you don’t need to worry about missing important attributes.
Using the X500B system and BioPharmaView Software, you’ll be able to analyze peptide mapping data in just four steps using, so you can make better decisions faster about your biologics products:
Fill out the form in the top right of this blog to download the Intact Mass Analysis and Peptide Mapping Solution Guides. These guides show how improved data acquisition and analysis workflows with SCIEX OS and BioPharmaView Software for the X500B QTOF System can transform your biotherapeutic characterization.
Trifluoroacetic acid (TFA) is emerging as one of the most concerning ultrashort-chain PFAS in Europe’s food supply – particularly in cereals, a staple consumed daily by millions. A report from PAN Europe reveals a widespread and largely unmonitored contamination trend that raises serious questions about food safety, regulatory blind spots, and future monitoring strategies.
PFAS analysis is complex, but expert guidance doesn’t have to be. In this episode of our ‘Ask the PFAS expert series’, we’re joined by Michael Scherer, Application Lead for Food and Environmental, to answer the most pressing questions in PFAS analysis. From why LC-MS/MS systems are the gold standard for analyzing diverse PFAS compounds, to which EU methods deliver reliable results for drinking water, and to practical steps to prevent contamination, Michael shares actionable insights to help laboratories achieve accuracy, consistency, and confidence in their workflows.
During an LC-MS/MS experiment, traditional fragmentation techniques like collision-induced dissociation (CID) have long been the gold standard. Electron-activated dissociation (EAD) is emerging as a transformative tool that enhances structural elucidation, particularly for complex or labile metabolites.
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