GEN-MKT-18-7897-A
Jul 14, 2017 | Blogs, Food / Beverage | 0 comments
Don’t judge a nutritional supplement by its label, as often, government monitoring of ingredients begins after the product enters the consumer market1. Meanwhile, there may be additional additives not mentioned on the label as they are used to address supplement side effects. Such is the case in the United States where even though federal law requires supplements to carry a dietary supplement label or a substitutional term, monitoring begins once a supplement is on the market. In China meanwhile, the China Food and Drug Administration’s (CFDA) health product potential illegal additives list, clearly stipulates monitoring processes for additives in six different types of nutritional supplements including weight loss, blood sugar reduction, blood pressure reduction, anti-fatigue, sleep improvement and immune strengthening functions.Read Tech Note >
Keeping up with additives is no small job for the labs tasked with analysis. A research report by Grand View Research notes that “The rising sales of sports nutrition products in the U.S. and China along with new product launches are likely to have a significant impact on the industry. The market is expected to generate revenues worth USD 37.16 billion by 2024.2
Since drug interactions can be unclear, however, they continue to merit clarity. In the following application note, Use of X500R QTOF for Monitoring Unexpected Additives in Nutritional Supplements, researchers used the X500R QTOF high-resolution mass spectrometry and SCIEX OS software for quick and qualitative confirmation of 50 additives. Want to see how your lab can keep up with supplemental screening? Download the tech note to discover how you can overcome matrix interference in complex matrices for the accurate testing of additives such as atenolol, nitrendipine, nifedipine, glibenclamide, glipizide, rosiglitazone, and gliclazide.
In monoclonal antibody (mAb) development, assessment of purity and integrity of the protein in question is critical. CE‑SDS is the gold standard assay and is routinely run from analytical development through QC and lot release. It’s trusted because it consistently delivers quantitative, size‑based insight into purity and fragmentation, and it fits naturally into regulated environments.
In drug discovery and development, Metabolite Identification (Met ID) plays a critical role in understanding biotransformation pathways, ensuring safety, and meeting regulatory requirements. Advanced mass spectrometry techniques have revolutionized this process, particularly through electron-based fragmentation methods such as Electron Activated Dissociation (EAD) and Electron Transfer Dissociation (ETD). While both techniques leverage electron interactions to generate informative fragment ions, they differ significantly in mechanism, performance, and suitability for Met ID workflows.
In analytical laboratories, performance is not optional. Whether supporting regulated pharmaceutical workflows, high-throughput CRO operations, clinical reporting, or food and environmental testing, your mass spectrometry and capillary electrophoresis systems are critical to productivity, compliance, and scientific confidence.
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