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Simplifying Polar Pesticides Within a Single Analysis

Feb 15, 2018 | Blogs, Food / Beverage | 0 comments

Glyphosate is a polar pesticide widely used as a garden herbicide. It is an ingredient in the world’s bestselling weed killer, which farmers consider one of their best solutions to their super weed problems.

However, the chemical has become one of the most controversial topics as concerns about health implications increase. What’s more, lack of rigorous testing methods has also drawn criticism. Yet, regulators across seem to have differing opinions on these issues and its widely used in farming is still authorized.

Many contemporary methods fail to address reproducibility and sensitivity. Consequently, labs are seeking even more efficient and robust analytical testing methods to help identify as many polar pesticides in food, feed, and environment, within in a single analysis.  

There are 2 constraints you need to know need when evaluating glyphosate testing methods:

  1. While ion chromatography has been shown to be beneficial for separation, there are downsides. The need for a suppressor is detrimental to MS analysis and the inefficiency of having to change inlet systems on a mass spectrometers systems that heavily work in reverse-phase LC.
  2. Previous analytical strategies, especially for LC-MS/MS analysis, have required laborious and often time-consuming derivatization of glyphosate and its metabolites to allow the polar nature of the compounds to be identified more easily under reverse-phase LC-MS conditions.

The good news? SCIEX has teamed up with NofaLab, a Rotterdam-based contract testing laboratory to develop a non-derivatized method.

This new method, is based on ion chromatography and optimized on the SCIEX 6500+ QTRAP® LC-MS/MS System, has high sensitivity, linearity, and reproducibility for food, feed, and water samples.

Download a content pack to learn more about this robust and sensitive method and how you can stay ahead of your glyphosate analysis. The content pack includes:

  • Comprehensive tech note which details the performance of this method
  • Recorded webinar from Wim Broer at Nofalab Laboratories
  • Overview flyer

 

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ADC analytics FAQs: Answering the most common questions about ADC characterization

Antibody-drug conjugates (ADCs) have emerged as one of the fastest-growing classes of biotherapeutics, combining the targeting specificity of monoclonal antibodies with the potency of cytotoxic payloads. However, this unique architecture also introduces significant analytical complexity. From drug-to-antibody ratio (DAR) distributions and charge variants to conjugation sites and structural modifications, ADCs present multiple, interconnected sources of heterogeneity that must be understood to ensure product quality and performance.

Sterile but toxic: Cereulide detection in food matrices

In a recent webinar, Ming Gao, Ph.D., Senior Research Chemist at Mérieux NutriSciences, explored the growing challenge of cereulide contamination in food products and the analytical strategies needed to detect this heat-stable toxin at trace levels. The session examined how LC-MS/MS can help laboratories overcome the limitations of traditional microbiological screening and meet emerging regulatory requirements.

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