GEN-MKT-18-7897-A
Mar 26, 2018 | Blogs, Software, Technology | 0 comments
Often by the time you’re aware of a problem, it’s too late, and disaster has already struck. You’re forced to pick up the pieces—downtime, reduced productivity and lost data.
When your PC goes down, IT comes to the rescue. That’s a reactive approach. In many cases, IT can predict when your PC will fail, based on remote monitoring and diagnostics.
Wouldn’t it be nice if there were a way to fix mass spectrometer issues before they snowballed into an instrument failure? This is where LC-MS remote monitoring comes in.
Mass spec remote monitoring allows your team to observe the current health your system efficiently—from anywhere, at any time. That means fewer surprises and maximized uptime.
Your SCIEX LC-MS systems are compatible with StatusScope® Remote Monitoring service. If you have a service or support contract, you just need to have it turned on by your SCIEX service professional. Enabling the StatusScope service will also require some help from your IT department.
A Case for StatusScope Remote MonitoringWhile most IT teams are familiar with the benefits of remote monitoring, network security and stability are their highest priority. Check out the following FAQ’s to help you explain the StatusScope service to your IT department, and address their concerns.
Question: How can I convince my IT team that StatusScope Remote Monitoring is secure?Answer: The StatusScope Remote Monitoring is unidirectional. This means all communication is initiated from inside your firewall. All communication is outbound-only, through port 443 with end-to-end encryption.
Only instrument operating parameters are monitored. Proprietary data is safe and not transmitted.
Question: What about encryption standards?Answer: All SSL communication supports only strong encryption standards (TLS 1.2 only) with no downgrade negotiation
StatusScope Remote Monitoring only supports Transport Layer Security (TLS 1.2), with no downgrade negotiation. Thus, you can be confident that all your instrument operating parameters are within a highly secure environment.
Question: I need to be sure my research data is secure. How do I ensure it won’t get leaked?Answer: Only instrument operating parameters are monitored. Proprietary data is safe. SCIEX does not collect or retain any analytic or assay information from connected devices.
Question: How do I know SCIEX is a reliable cloud provider?Answer: StatusScope Remote Monitoring is built on the Axeda Machine Cloud platform from PTC Corp, an industry leader in IoT. PTC has Tier 1 data centers in global locations and is ISO 27001 certified. SCIEX is not running its own cloud; all data transactions happen in the PTC cloud.
Question: I like the idea of mass spec remote monitoring services, but how do I convince my IT team to take on the project?Answer: Your IT Team can implement the StatusScope Remote Monitoring Services with little effort. IT only needs to facilitate outbound HTTPS traffic. There is no need to open any new ports. A small number of external IP addresses need to be whitelisted for the StatusScope service to work.
Question: With all the data my research generates, how do I know StatusScope Remote Monitoring will not fill up our bandwidth?Answer: StatusScope requires low bandwidth, similar to someone performing occasional web browsing.
Finding the right information shouldn’t slow you down. Whether you’re troubleshooting your mass spec, learning something new, or optimizing performance, access to the right resources at the right moment makes all the difference.
As an analytical strategy, middle-down mass spectrometry (MS) workflows characterize biotherapeutic proteins by analyzing large, digested protein fragments or defined subunits, rather than fully intact proteins (top-down) or digested peptides (bottom-up). A middle-down strategy combines the strengths of top-down and bottom-up approaches by delivering high sequence coverage and structural specificity while maintaining relatively simple sample preparation. In practice, middle-down analysis enables accurate mass measurement, rapid sequence confirmation, and localization of key post-translational modifications (PTMs) on protein subunits that are directly relevant to product quality.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
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