GEN-MKT-18-7897-A
Apr 2, 2019 | Biopharma, Blogs, Pharma | 0 comments
New technologies can transform a laboratory’s throughput and efficiency. At Alturas, if we try out a new technology, we ask:
When we look at the convenience, uptime, and overall data that we’re getting from microflow LC-MS/MS with the SCIEX OptiFlow™ Turbo V source – we know we’re getting better results.
In our work, we analyze large molecules from biological fluids and matrices. The traditional approach, using ligand binding assays, can have real selectivity problems – sometimes even stopping a therapeutic in late stage development. Microflow LC and an optimized source system has us declaring: Problem solved!
I recently gave a webinar called, Soup to Nuts of Large Molecule LC-MS/MS Bioanalysis, and you can watch it on-demand now >
In this blog, I’ll share a Q&A based on some of our experiences. It might have you asking if you should switch to microflow LC-MS/MS for your large molecule bioanalysis, too.
Eight Things You Want to Know About Microflow LC-MS/MS and the OptiFlow Turbo V Source
We hope our answers have been helpful to you! If you’d like more details about our work, please watch this video.
Learn more about the SCIEX OptiFlow Turbo V Source >
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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