GEN-MKT-18-7897-A
Aug 5, 2015 | Blogs, Food / Beverage | 0 comments
Did you know that even though most of the world is covered in water, access to clean drinkingwater remains a problem? Take Asia for example where 62,000 people have lost their lives between 2001 and 2005 due to water-related disaster and illness.
Clean water is easier said than done, however, as more than a thousand chemical contaminants threaten our supply. Commercial waste, runoff and groundwater discharge including pollution from human waste, industrial use, and agriculture remain a problem. How then can we help world health organizations get a better handle on this epidemic? Improved sanitation helps, but so too does more advanced testing technology and SCIEX is in on the solution. A recent study by our scientists experimented with sample preparation and data processing according to EPA Method 537.
Want to Know Which Method for Testing Water Quality Came out on Top? Hands-down, it is mass spectrometry (MS) because of its ability to detect very low levels of a variety of chemical compounds. These range from pesticides and pharmaceuticals and personal care products (PPCP) to residual explosives and disinfection by-products.
A single test, just one, is all it takes to discover what lurks in drinking water when using MS. Imagine how many people could be saved from water-borne illnesses if world health organizations were able to adopt more advanced technology. If you are someone who is interested in uncovering how mass spectrometry can help advance water testing or know someone who is, read the full report.
Read About Additional Water Studies >
Finding the right information shouldn’t slow you down. Whether you’re troubleshooting your mass spec, learning something new, or optimizing performance, access to the right resources at the right moment makes all the difference.
As an analytical strategy, middle-down mass spectrometry (MS) workflows characterize biotherapeutic proteins by analyzing large, digested protein fragments or defined subunits, rather than fully intact proteins (top-down) or digested peptides (bottom-up). A middle-down strategy combines the strengths of top-down and bottom-up approaches by delivering high sequence coverage and structural specificity while maintaining relatively simple sample preparation. In practice, middle-down analysis enables accurate mass measurement, rapid sequence confirmation, and localization of key post-translational modifications (PTMs) on protein subunits that are directly relevant to product quality.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
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