Drug Metabolism and Bioanalysis Journal Articles Focus on Drug Metabolism and so Much More

Jan 18, 2016 | Blogs, Pharma | 0 comments

Check-out the top articles that focus on innovations in drug metabolism as well as small molecule quantitation and biologics bioanalysis. Exciting advancements! We can’t wait to see all that will come in 2016!

  1. Quantitative analysis of maytansinoid (DM1) in human serum by on-line solid phase extraction coupled with liquid chromatography tandem mass spectrometry – Method validation and its application to clinical samples
  2. Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC–MS/MS approach: Assay development, validation, and a case study
  3. An integrated multiplatform bioanalytical strategy for antibody–drug conjugates: a novel case study
  4. Accurate and sensitive liquid chromatography/tandem mass spectrometry simultaneous assay of seven steroids in monkey brain
  5. Quantitative analysis of intracellular nucleoside triphosphates and other polar metabolites using ion pair reversed-phase liquid chromatography coupled with tandem mass spectrometry
  6. Comprehensive Characterization of Low Molecular Weight Heparins Using High-Resolution Mass Spectrometry
  7. Quantitative Analysis of Transporter Protein using TripleTOF® 6600 System
  8. Trends in Bioanalysis Using LC–MS–MS
  9. Comprehensive characterization of protein therapeutics using CESI, exceptional resolution combined with MS
  10. Identification of metabolites of oridonin in rats with a single run on UPLC-Triple-TOF-MS/MS system based on multiple mass defect filter data acquisition and multiple data processing techniques
  11. Rapid identification of efavirenz metabolites in rats and humans by ultra-high performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry
  12. Software automation tools for increased throughput metabolic soft-spot identification in early drug discovery
  13. Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple quadrupole/time-of-flight mass spectrometry
  14. Comparison of Information-Dependent Acquisition, SWATH, and MSAllTechniques in Metabolite Identification Study Employing Ultrahigh-Performance Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry
  15. High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis
  16. Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle
  17. Quantitation of Insulin Analogue Glargine and Its Two Metabolites M1 and M2 on Triple Quad 6500 and Triple TOF 5600 LC-MS/MS Systems in a Dog Toxicokinetics Study
  18. Performance enhancement in the measurement of 5 endogenous steroids by LC-MS/MS combined with differential ion mobility spectrometry
  19. Differential Mobility Separation of Leukotrienes and Protectins
  20. Rapid Quantification of Digitoxin and Its Metabolites Using Differential Ion Mobility Spectrometry-Tandem Mass Spectrometry

Telling the PFAS story with pine needles

As an ever-expanding group of chemicals, per- and polyfluoroalkyl substances (PFAS) require novel techniques to monitor their current and historical presence in the environment. Concerns over exposure to PFAS chemicals continue to grow, with some having known toxic characteristics and the potential effects of others remaining unknown.1 In addition, while PFAS are one of the most persistent synthetic chemicals to date, most of them hardly degrade in the environment.2 So, how long do traces of PFAS last in our environment? Two tools used to help answer this question are active samplers and passive samplers.

Back to the new basics: Part 3 | LC vs. LC-MS and what it means for your lab

In this final installment of our “Back to the new basics” series, we take one more look at analytical techniques and best practices in the lab, and opportunities to improve efficiency. Here, we explore the basic principles of high-performance liquid chromatography (LC) and liquid chromatography mass spectrometry (LC-MS), and how these techniques can affect a lab’s efficiency and productivity.

Meat vs plant based. What is the best option?

As we become more conscious about the planet, healthier lifestyles and our duty to protect the environment, attitudes and behaviours are shifting when it comes to food consumption.

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