GEN-MKT-18-7897-A
Jun 20, 2016 | Blogs, Environmental / Industrial, Food / Beverage | 0 comments
No other pesticide has courted more media attention and controversy in recent months than glyphosate, with governments and national agencies debating its use and health effects. The following links just show some of the media attention this organophosphorus compound has received:
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However irrespective of whether it poses a risk or not the analysis of glyphosate and other polar compounds in food and beverage products has been a challenge. Attaining the required sensitivity, dealing with complex matrices and sample prep can put a serious strain and demand on your laboratory. A common practice for the analysis of glyphosate and the other associated polar compounds such as AMPA, Glufosinate, and MMPA is to derivatize the samples during the preparation.
The derivatization method may be effective however there is a serious efficiency problem associated with it, the time it takes the analysts to prep and extract the sample. Derivatization can be a time-consuming procedure and can, therefore, affect a lab’s productivity, turnaround, and margins.
In a recent presentation, on the QTRAP® 6500+ System, we conducted an in-depth evaluation into the Quantitation of Underivatized Glyphosate and Other Polar Pesticides. This comprehensive study details the various techniques and LC conditions that we tested on a variety of matrices. In this study, we show how the SelexION® reduces interferences and can meet your required levels of sensitivity.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
At SCIEX, innovation doesn’t stop at instruments; it extends to how you interact with your LC-MS/MS or CE systems every day. That’s why we’re excited to introduce the SCIEX Now spring 2026 improvements: a set of meaningful enhancements shaped directly by your feedback.
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