Three Infographics to Show You How to Overcome Challenges in Transitioning to Biologics Bioanalysis

Jul 8, 2016 | Biopharma, Blogs | 0 comments

The move to large molecules in Pharma is accelerating, offering unprecedented opportunities to improve human health and expand into new markets. But for those with extensive experience with small molecule bioanalysis, the shift to biologics can be challenging, from Sample Prep to Instrumentation and Software, to Methods and Training:

  • Sample Prep is complex
    • Every new biologic requires a specific sample prep strategy: sourcing reagents and researching protocols
    • Bioanalysis studies have large sample numbers
    • Tedious manual steps for enrichment, digestion, and clean-up can result in high variability
  • Instrumentation and Software have to be up to the task
    • Efficient MRM optimization is required for chromatography, multiple charge states, declustering potential and collision energy
    • Maximal sensitivity is needed for low abundance samples
    • Enhanced selectivity is important to overcome matrix interference
    • Simple software for complex data is essential, which can handle large sample sets and batches
  • Methods and Training are needed to get running quickly
    • You have to develop your sample prep protocol, source reagents and optimize your LC-MS methods, which can take months
    • You have to train your scientists to understand and run the new methods: how are you going to do it?

The challenges seem daunting, but SCIEX can help you overcome them with relative ease.  Download a three-part infographic that addresses all three challenges and describes the solutions with links to useful reference material.  The SCIEX BioBA Solution will get you up and running quickly and painlessly.Download Infographic >

Telling the PFAS story with pine needles

As an ever-expanding group of chemicals, per- and polyfluoroalkyl substances (PFAS) require novel techniques to monitor their current and historical presence in the environment. Concerns over exposure to PFAS chemicals continue to grow, with some having known toxic characteristics and the potential effects of others remaining unknown.1 In addition, while PFAS are one of the most persistent synthetic chemicals to date, most of them hardly degrade in the environment.2 So, how long do traces of PFAS last in our environment? Two tools used to help answer this question are active samplers and passive samplers.

Back to the new basics: Part 3 | LC vs. LC-MS and what it means for your lab

In this final installment of our “Back to the new basics” series, we take one more look at analytical techniques and best practices in the lab, and opportunities to improve efficiency. Here, we explore the basic principles of high-performance liquid chromatography (LC) and liquid chromatography mass spectrometry (LC-MS), and how these techniques can affect a lab’s efficiency and productivity.

Meat vs plant based. What is the best option?

As we become more conscious about the planet, healthier lifestyles and our duty to protect the environment, attitudes and behaviours are shifting when it comes to food consumption.

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