GEN-MKT-18-7897-A
Jun 26, 2017 | Blogs, Food / Beverage | 0 comments
Up until recently, SWATH® Independent Data Acquisition (IDA), was not widely used for the detection of pesticides in food samples. Introduced in 2012, SWATH Acquisition is an advanced acquisition technology capable of running on high-resolution mass spectrometers such as the X500R QTOF system or Triple TOF technology. Originally used in the Omics market to ID and quantify complex samples, SWATH Acquisition is gradually making a transition across markets including the investigation of pesticides in food. Like designer drugs, pesticides continuously undergo synthesizing, and food labs are beginning to require a more reliable analysis method to be confident in their resulting reports.Download Technote >
I talked about SWATH in food testing a couple of months ago and wish to bring up the subject again as labs make a push to keep up with regulatory requirements. Targeted analysis has been the benchmark for GC-MS and LC-MS methods for years, but as more and more labs compete for market share, higher end instruments capable of Independent Data Acquisition (IDA) are on point. The benefits being that SWATH Acquisition has evolved to address small molecule compounds making it ideal for routine pesticide, mycotoxin, and veterinary drug analysis. Furthermore, the IDA scanning function results in fragmentation information for all ions in the entire mass range so researchers are confident they are detecting all compounds in a sample instead of relying on selective ions.
In the following technical note, “X500R QTOF System with SWATH® Acquisition for Pesticide Residue Screening in Fruits and Vegetables,” researchers demonstrate how to achieve an all-in-one process analysis with instrument control, data acquisition and data processing using, you guessed it, SWATH Acquisition. If you are hesitant to attempt this type of analysis, don’t be. The above application note walks you through the set-up process and data analysis of the 190 most commonly used types of pesticides for the Ministry of Agriculture risk assessment.
The Take Away: The experiment used the SCIEX X500R QTOF System’s SWATH technology to screen pesticide residues in six varieties of vegetables and fruits, among which leeks, kidney beans, and jujube contained six or more types of pesticide residue. Find out which sample exceeded the limits of pesticide residue and how researchers obtained the primary and secondary data of all pesticide residues by singularly entering the samples. Uncover how to directly establish methods using SCIEX OS and more when you read the tech note.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
CE‑SDS remains a cornerstone assay for characterizing fragmentation, aggregation, and product‑related impurities in therapeutic proteins. UV detection has been the long‑standing standard. However, it frequently struggles with baseline noise, limited sensitivity for minor fragments, and subjective integration.
At SCIEX, innovation doesn’t stop at instruments; it extends to how you interact with your LC-MS/MS or CE systems every day. That’s why we’re excited to introduce the SCIEX Now spring 2026 improvements: a set of meaningful enhancements shaped directly by your feedback.
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