GEN-MKT-18-7897-A
Jun 26, 2017 | Blogs, Food / Beverage | 0 comments
Up until recently, SWATH® Independent Data Acquisition (IDA), was not widely used for the detection of pesticides in food samples. Introduced in 2012, SWATH Acquisition is an advanced acquisition technology capable of running on high-resolution mass spectrometers such as the X500R QTOF system or Triple TOF technology. Originally used in the Omics market to ID and quantify complex samples, SWATH Acquisition is gradually making a transition across markets including the investigation of pesticides in food. Like designer drugs, pesticides continuously undergo synthesizing, and food labs are beginning to require a more reliable analysis method to be confident in their resulting reports.Download Technote >
I talked about SWATH in food testing a couple of months ago and wish to bring up the subject again as labs make a push to keep up with regulatory requirements. Targeted analysis has been the benchmark for GC-MS and LC-MS methods for years, but as more and more labs compete for market share, higher end instruments capable of Independent Data Acquisition (IDA) are on point. The benefits being that SWATH Acquisition has evolved to address small molecule compounds making it ideal for routine pesticide, mycotoxin, and veterinary drug analysis. Furthermore, the IDA scanning function results in fragmentation information for all ions in the entire mass range so researchers are confident they are detecting all compounds in a sample instead of relying on selective ions.
In the following technical note, “X500R QTOF System with SWATH® Acquisition for Pesticide Residue Screening in Fruits and Vegetables,” researchers demonstrate how to achieve an all-in-one process analysis with instrument control, data acquisition and data processing using, you guessed it, SWATH Acquisition. If you are hesitant to attempt this type of analysis, don’t be. The above application note walks you through the set-up process and data analysis of the 190 most commonly used types of pesticides for the Ministry of Agriculture risk assessment.
The Take Away: The experiment used the SCIEX X500R QTOF System’s SWATH technology to screen pesticide residues in six varieties of vegetables and fruits, among which leeks, kidney beans, and jujube contained six or more types of pesticide residue. Find out which sample exceeded the limits of pesticide residue and how researchers obtained the primary and secondary data of all pesticide residues by singularly entering the samples. Uncover how to directly establish methods using SCIEX OS and more when you read the tech note.
The Echo® MS+ system is a novel platform for Acoustic Ejection Mass Spectrometry (AEMS) and combines the speed of acoustic sampling with the selectivity of mass spectrometry. This platform has been designed for high throughput analysis of small and large molecules. The technology combines Acoustic Droplet Ejection (ADE), an Open Port Interface (OPI) and could be coupled with the SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system.
The Echo® MS+ system comprises of an open-port interface (OPI) and acoustic droplet ejection (ADE) module which could be coupled with a mass spectrometer. The mass spectrometer could either be a SCIEX Triple Quad 6500+ system or the ZenoTOF 7600 system. This non-liquid chromatography based; high-throughput screening platform enables rapid analysis of compounds at speeds of up to 1 sample/second.
The ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
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