Comprehensive characterization of a biologic requires analysis at both the intact and digest levels, but these analyses can be complex and cumbersome. For example, with conventional liquid chromatography separations, researchers are often left with limited information due to problems with either very small or very large protein and peptide retention. Unfortunately, slow going methods like these do not mesh with the rapid onset of novel drug approvals and researchers are left wanting more.  As in, a more reliable and comprehensive process for characterizing biologics to move them through the drug development pipeline, without compromising on results.Download the Latest Biologics Research >

Go with the CESI-MS Flow
The good news is there are alternatives to existing workflows. For example, using CESI coupled with mass spectrometers (CESI-MS), researchers gain a more comprehensive biologic outlook while at the same time saving almost a day’s worth of time in the lab. Intrigued? We’ve put together in an online eBook that provides vivid illustrations, application notes, and video demonstrations for a solid multi-level characterization biologic foundation, and it’s all here for the taking. This is not your typical brochure, but rather a self-guided tour to be shared with your co-workers as they ask questions and get immediate answers to their most pressing characterization questions. Discover ways to advance your biologics characterization studies using instrumentation like the CESI 8000 Plus coupled with a TripleTOF^® mass spectrometer. Together, they give you high-resolution separations with the unique detection capabilities and dedicated software designed for biologics analysis.  From intact analysis to peptide mapping, get an inside look at how CESI-MS can advance your investigations of glycosylation, a drug to antibody ratio (DAR), disulfide bond mapping, and PTM identification. Go inside the lab and see the instrument at work using single injection technology for multi-level characterization of a biotherapeutic. Alternatively, view a video showing how powerful software solutions can help you to simplify your comparability work– all in this feature-rich online guide. It’s an interactive tour that gives you all the insight you need for linking CESI technology to high-performance mass spec.