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Quantitation of Antibiotics and Insecticides in Poultry Feed using LC-MS/MS

Aug 22, 2016 | Blogs, Food / Beverage | 0 comments

Quantitating antibiotics and insecticides in poultry is serious business. Overuse can lead to antibiotic resistance while insecticide residuals can cause harmful side effects in humans. In the United States, for example, the Federal Drug Administration (FDA), has offered up a plan to limit common antibiotics in feed, which are used to encourage growth. However, this is a voluntary plan, and as the following application note, “Quantitation of Antibiotics and Insecticides in Poultry Feed using LC-MS/MS,” points out, antibiotics have been shown to accumulate in poultry feathers, which are in turn used for nutritional elements in the feed.  Therefore, as the government agency works on getting suppliers on board with the new plan, scientists are working on a testing method of their own which detects nine antibiotics and four insecticides in poultry feed including:

  • Fluoroquinolones
  • Sulfonamides
  • Amphenicols
  • Macrolides
  • Quinolones

Perhaps you have seen this study, but just in case you missed it, we have included the full report in the Food & Beverage Compendium, which is now available for download.Download the Food & Bev Compendium >

Application Note at a Glance: To give you more insight into this application note and others like it in the compendium, consider how poultry feed contains many nutritional ingredients. Researchers had to design a method that included a hefty extraction method and clean-up efforts. As a result, they designed a single method to quantify a wide selection of antibiotics and insecticides in poultry feed using a QTRAP® 5500 for detection. Want to see how the extraction/sample prep was carried out? These experimental conditions along with separation and MS/MS detection are included within the compendium (pages 121 to 125). 

The Food & Beverage Compendium is full of similar studies on topics including:

  • Antibiotics
  • Allergens
  • Pesticides
  • Authenticity
  • Mycotoxins
  • Vitamins
  • Packaging

Discover where science is taking Food and Beverage with this FREE, and Informative Compendium. 

Questions and answers to help improve your mycotoxin analysis

During a recent webinar I shared method details for mycotoxin analysis on the SCIEX 7500 system. In this blog i will share the Q&A for the submitted questions that we did not have chance to answer during the live webinar.

A 2-fold revolution: MS approaches for the bioanalysis of oligonucleotide therapeutics

In 1998, the US Food and Drug Administration (FDA) approved fomivirsen as the first therapeutic oligonucleotide therapeutic. This approval marked a revolution of mechanism of action discovered decades before finally coming to fruition. Since then, the landscape of chemical modifications of oligonucleotides, conjugations and formulations has evolved tremendously, contributing to improvements in stability, efficacy and safety. Today, more than a dozen antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) drugs are on the market, most of which are designated as orphan drugs for treating rare genetic diseases.

Is “right first time, every time” a pipedream for metabolite identification by LC-MS?

If we lived in an ideal world, it would be possible to unambiguously identify metabolites using a single analytical experiment. This analytical technique would need to be efficient and easily generate the information needed from a routine assay that is also robust, enabling confident decision-making during drug discovery.

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