GEN-MKT-18-7897-A
Oct 2, 2018 | Biopharma, Blogs, Life Science Research | 0 comments
There are a lot of conferences vying for your attention every year. The Global CESI-MS Symposium on October 10-11 in the Netherlands is one you can’t afford to miss. It is the place to hear about the latest advancements made through the adoption of CESI-MS technology.
Have you signed up yet? If not, keep reading to find out more.
What is CESI-MS?The integration of Capillary Electrophoresis (CE) with Electrospray Ionization (ESI) into a single dynamic process within the same device brings new capabilities to biopharmaceutical, proteomics, metabolomics, and industrial researchers. When paired with a mass spectrometer, CESI-MS delivers a revolutionary approach to discovering previously undetectable characteristics from the minutest precious sample.
The Global Symposium provides a platform for scientists in biopharma, proteomics, metabolomics research, and applied markets to share knowledge and advance their work with CESI-MS technologies. Organized by SCIEX, over the last three years, the event has become synonymous with innovation, check out last year’s presentations.
What’s on the Agenda?Find out about the unique features of CESI-MS and how it is helping to push research and applied applications to the very limits. You will hear how CESI-MS is making inroads in applications where researchers are working with very limited amounts of samples, such as charged and polar analytes in metabolite profiling, and intact proteins in proteomics and biopharma. Professor Govert Somsen and Professor Manfred Wuhrer will host the two-day program which is packed with presentations and Q&A sessions featuring 15 industry innovators – see the full agenda here.
What’s New In CESI-MS in 2018?At the Symposium you will hear about scientific breakthroughs in a range of applications, including:
These are just four examples of the many exciting pioneering stories we will hear at the 2018 Global CESI-MS Symposium.
Why Should I Attend?Over two days of presentations and Q&A, you will discover strategies, methods, and breakthroughs achieved with CESI-MS. This is a rare opportunity to hear and discuss these great cases, first-hand.
So, what are you waiting for? Come and join us at the 2018 Global CESI-MS Symposium on October 10-11, 2018 at Leiden University Medical Center (LUMC) in The Netherlands.
Spaces are filling fast; we hope to see you there.
Finding the right information shouldn’t slow you down. Whether you’re troubleshooting your mass spec, learning something new, or optimizing performance, access to the right resources at the right moment makes all the difference.
As an analytical strategy, middle-down mass spectrometry (MS) workflows characterize biotherapeutic proteins by analyzing large, digested protein fragments or defined subunits, rather than fully intact proteins (top-down) or digested peptides (bottom-up). A middle-down strategy combines the strengths of top-down and bottom-up approaches by delivering high sequence coverage and structural specificity while maintaining relatively simple sample preparation. In practice, middle-down analysis enables accurate mass measurement, rapid sequence confirmation, and localization of key post-translational modifications (PTMs) on protein subunits that are directly relevant to product quality.
In biopharmaceutical development, sequence variants (SV) are considered an inherent risk of producing complex proteins in living systems. Sequence variants are unintended changes to the amino acid sequence of a biotherapeutic and can be caused by errors in transcription or translation in the host cell, or cell culture and process conditions. Detailed analysis of SVs is important in process and product development to ensure the drug’s safety and efficacy. Even low‑level sequence variants can have significant implications for product quality, safety, and efficacy, making their accurate detection and characterization a critical requirement across development, process optimization, and regulatory submission.
Posted by
You must be logged in to post a comment.
Share this post with your network