Where did it start? Nitrosamines are a large group of N-nitroso compounds that share a common functional N-N=O group. They are produced by a chemical reaction between a nitrosating agent and a secondary or tertiary amine. Back in 2018, nitrosamines suddenly found...
Read time: 3 minutes You probably have heard of testing blood and urine samples for the presence of drugs and their metabolites. But do you know about the benefits of hair and nail analysis? In a recent webinar, Tina Binz, Deputy Head of the Center for Forensic Hair...
We know that LC-MS oligonucleotide analysis can have its share of challenges—challenges with sensitivity, challenges with adduct formation and challenges with data analysis, to name just a few. That’s why this blog takes a closer look at the dos and don’ts of this...
Read Time: 7 minutes On June 12, 2023, during a webinar hosted by New Food, Lin Qingsong—Principal Research Fellow and Director of the Protein and Proteomics Centre at the National University of Singapore—discussed the latest considerations related to risk assessment...
Read time: 2 minutes As we become more conscious about the planet, healthier lifestyles and our duty to protect the environment, attitudes and behaviours are shifting when it comes to food consumption. ‘Fake’ meat and the environment Nowadays, meat or fish is...
In this interview from the Science Explorer about the Echo® MS system, Neil Walsh from SCIEX discusses the significant application areas of the system and what makes it so attractive to biopharmaceutical laboratories. Here is a snippet of the...
Read time: 15 minutes The completion of the human genome project in 2003 opened the door to unprecedented insight into the human body through its DNA code. We now know that our genome encodes our proteins, that our proteins are the molecular machinery of certain...
There are over 7,000 genetic diseases that could potentially be cured using gene therapy. Rare metabolic diseases, autoimmune disorders, cardiovascular disease and cancers are some of the top disease classes that can be addressed with gene therapies. With over 1,000...
Comprehensive characterization of a biologic requires analysis at both the intact and digest levels, but these analyses can be complex and cumbersome. For example, with conventional liquid chromatography separations, researchers are often left with limited information...
For many of you working to develop gene therapy drugs, you know that the time to market the drug is critical. Because gene therapeutics cure diseases by targeting specific genes, it is a constant race to see who develops the drug first. Unlike other classes of drugs...
It’s important to know what you’re eating, especially if you suffer from a food allergy. About 220 million people worldwide live with a food allergy.1 These numbers, along with the complexity and severity of conditions, continue to rise. In America, there are about 32...
Over the last several years there has been a slow and steady progression within the LC-MS community to move traditional high-flow applications to lower flow rates. In particular, moving into the microflow regime has proven to be a simple adjustment in methodology that...