Dr. Michael Pötzsch, Institute of Forensic Medicine,University of Zurich Mass spectrometry techniques are now commonplace for high throughput quantitation and screening, but also for research and discovery for food safety, forensics, environmental testing, and a host...
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Take on New Analytical Challenges with the TripleTOF 6600 Accurate Mass System
Stay ahead of the curve by using the most advanced and versatile high-resolution accurate mass technology. The TripleTOF® 6600 accurate mass QTOF system can help you to analyze your samples faster, without compromising between speed, resolution, and sensitivity....
3 Workflows Designed to Accelerate Your Biologics Characterization
Biopharmaceutical development is booming and now an integral part of many pharmaceutical company pipelines. While these emerging biologics present exciting opportunities for the industry, their sophistication is challenging the limits of characterization at all stages...
Making Your Vitamin D Testing Dreams Come True
If you work in clinical diagnostics, you can probably confirm that most clinical laboratories have seen a 5 to 6-fold increase in 25-hydroxyvitamin D testing over the past decade, and volume is growing. Furthermore, the Office of Inspector General (OIG) recently...
The Science Behind SelexION Differential Mobility Spectrometry Technology
Scientists and analysts across all fields of testing and research are increasingly challenged by complex samples requiring advanced analytical selectivity. And where LC-MS/MS sensitivity alone is not enough to meet the demands of modern day quantitative performance,...
Elimination of Interference using the SelexION Differential Mobility System for the Quantitation of Rituximab in a Dual Surrogate Peptide Approach
The quantitation of proteins using the surrogate peptide approach can complicate nominal mass Triple Quadrupole MRM measurements due to co-extracted interference when using non-selective extraction techniques such as pellet digestion. High resolution coupled with...
5 Tips for Calibrating a QTOF Mass Spectrometer
Do you have questions about your mass spec? How about a workflow? Our community members are involved in active discussions and receive expert answers from customers like you, SCIEX scientists, and support specialists every week. One recent topic concerned...
Enhancing In Vitro ADME Screening
Dr. Graeme Clark, Head of Analytical Sciences, Cyprotex Discovery Ltd. LC-MS technology is helping contract research organization Cyprotex Discovery Ltd. perform bioanalysis of small molecules, peptides, and other pharmaceuticals, enabling quantification to be...
Host Cell Protein Analysis – Mass Spec’s Edge Over ELISA
The number of protein based drugs coming onto the market is at an all-time high, particularly those produced with a host cell system. With host cells come their own proteins. These host cell proteins (HCPs) constitute a major part of process-related impurities and can...
Why Microflow HILIC Chromatography for Targeted Metabolomics Applications?
I recently had the opportunity to catch up with Baljit Ubhi to discuss the top questions you're asking in regards to using Microflow HILIIC Chromatography for Targeted Metabolomics. Here's what Bal said: Why is analyzing polar metabolites so challenging? Many of the...
Fipronil Tainted Eggs Detected in Several European Countries
Fipronil Contamination in Eggs News agencies all over the world are reporting a new food contamination issue regarding eggs which have been found to contain residues of Fipronil. According to Nieuwsuur, a Dutch news, and current affairs program, "The Fipronil scandal...
In Search of the Unknown
Dr. Wolfgang Schulz, Head of R&D Special Analysis, Laboratory of Operation Control and Research, Zweckverband Landeswasserversorgung The production of high-quality drinking water entails rigorous treatment and testing procedures. For water suppliers’ laboratories,...