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It’s Time to Turn Things Around―Faster and Accurate Mass Analysis of Organic Explosives

Oct 5, 2018 | Blogs, Forensic | 0 comments

Sadly, the world is a volatile place. The threat of organic explosive use by terrorists and criminals is very much with us, posing a significant danger to people worldwide. The rising concern for public safety is a top priority for national security organizations around the world, to be able to protect citizens, but also to act quickly in the event of an incident.

From fireworks to firearms, if an explosion occurs a detailed investigation reveals vital clues that help investigators piece together what happened. Whether in a war zone or civilian spaces, information from an exploded device will not only provide answers to support a case but will help us to assess better and understand the devastation that these objects can leave behind.

Advanced Analysis of Organic Explosives
With the daily occurrence of explosives found in crime scenes, advanced forensic analysis after blasts will help us to solve more crimes, stay ahead of more attacks and help neutralize threats. But it can be challenging to analyze trace amounts of organic explosive residue. Traditional analytical methods often fail to provide the essential throughput and selectivity required to identify key components of a crime scene involving explosives.

Forensic scientists need sensitive and accurate screening techniques to identify explosive materials, fast.
High-resolution liquid chromatography-mass spectrometry (HPLC-MS) provides the answer. With acquisition rates at up to 100 MS/MS per second and the ability to perform comprehensive analysis, samples left behind from organic explosives can be analyzed in under three minutes. This, of course, includes the 14 most important known explosives making it hard to find another analytical method that comes close. HPLC-MS offers a greater level of explosive occurrence information leading to increased confidence in compound identifications.

  • Fast, specific and sensitive analysis of organic explosives
  • High-resolution MS/MS characterization at fast acquisition rates
  • Accurate mass information at low analyte concentrations
  • Easily build and optimize targeted methods on different analytes
  • Comprehensive detection and quantitation of every detectable compound

We can bring this to life for you in this technical note: High Throughput Platform for Confident Identification and Quantitation of Organic Explosives. You will see how the SCIEX X500R System powered by SCIEX OS Software delivers fast, specific and sensitive analysis of the most common organic explosives encountered in forensic analytical settings, and how we achieve the levels of performance detailed above.

Complete the form on the right to download the Forensics Compendium that features this tech note.

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In 1998, the US Food and Drug Administration (FDA) approved fomivirsen as the first therapeutic oligonucleotide therapeutic. This approval marked a revolution of mechanism of action discovered decades before finally coming to fruition. Since then, the landscape of chemical modifications of oligonucleotides, conjugations and formulations has evolved tremendously, contributing to improvements in stability, efficacy and safety. Today, more than a dozen antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) drugs are on the market, most of which are designated as orphan drugs for treating rare genetic diseases.

Is “right first time, every time” a pipedream for metabolite identification by LC-MS?

If we lived in an ideal world, it would be possible to unambiguously identify metabolites using a single analytical experiment. This analytical technique would need to be efficient and easily generate the information needed from a routine assay that is also robust, enabling confident decision-making during drug discovery.

Supporting new CRISPR gene editing systems

Prime editing (PE) is a next-generation gene editing technology that utilizes a Cas9 protein fused to a prime editing guide ribonucleic acid (pegRNA) to achieve high CRISPR/Cas9 editing efficiency and precision. However, the length requirement of pegRNAs at 120–250 nucleotides (nt) and their high level of secondary structure formation present analytical challenges for the purity analysis of chemically synthesized pegRNAs during development and quality control (QC).

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