Characterization and quantification of host cell proteins (HCPs) in biopharmaceutical development and manufacturing is a critical step to ensuring product safety. While this can be achieved using ELISA, mass spectrometry using the SCIEX TripleTOF® 6600...
When developing new quantitative assays for Biotherapeutics, every biologic requires a specific sample prep strategy, which includes sourcing reagents and research protocols. However, as every bioanalytical lab knows all too well, it can also take up to two months to...
Up until recently, SWATH® Independent Data Acquisition (IDA), was not widely used for the detection of pesticides in food samples. Introduced in 2012, SWATH Acquisition is an advanced acquisition technology capable of running on high-resolution mass spectrometers such...
The consumption of pharmaceuticals and personal care products is a day to day occurrence. Once consumed the body excretes the remaining part of the compound which is not absorbed. This waste, flushed down the toilet, makes its way through the sewage system before...
Are you tasked with the bioanalysis of antibody drug conjugates (ADCs)? If so, you know they represent a rapidly growing class of biotherapeutics, but their unique chemical structure makes quantitative analysis particularly challenging. So, what is the best technique...
A recent study published by the Annals of Allergy, Asthma, and Immunology (ACAAI), pointed out, in a study of 109 people tested, that skin prick tests are not 100 percent reliable. In the study, participants were subjected to oral food challenges prior to skin testing...
Get to know how CESI-MS will allow you to quickly and accurately characterize protein therapeutics for attributes in a single method by downloading this discovery kit.The Biologics Characterization and Discovery Kit Includes: Executive Summary Tech Note: A Unified...
Dr. Amadeo R Fernández-Alba, EURL for Fruits and Vegetables, University of Almería The EU Reference Laboratory (EURL) for Fruits and Vegetables in Almería is responsible for a network of around 200 laboratories which provide essential surveillance and monitoring to...
If you work in the breakneck world of therapeutic development, then you probably don’t even have time to read this blog (but we thought we would write it anyways, just in case). Drug metabolism samples are coming into your lab fast and furious. You need to turn them...
When you’re in the process of moving your lab, across the corridor or to another country, there’s a lot to think about. Adding to the stress, there’s not always a lot of time to plan, or budget allocated for the process, especially in the case of unexpected urgent...
Adding colorful dyes to food is nothing new. In the early 19th century, for example, it wasn’t uncommon for manufacturers to add chalk to white bread, thicken milk with a lead compound, and inject red dye into meat in the quest for a fresher appearance1. Fast forward...
From small ions like phosphate, herbicide degradation to metabolites, oligosaccharides, peptides, and proteins. How is your lab analyzing polar molecules? The reason I ask is there is a saying, if you have a charged or polar molecule, look to capillary electrophoresis...