A new approach for comprehensive AAV evaluation including full and empty analysis by Kerstin Pohl | 0 CommentsCertain next-gen vaccines and gene therapy applications rely on the usage of adeno-associated viruses (AAV) as a delivery vehicle. To ensure the safety and efficacy of viral vector drugs, multiple critical quality attributes (CQAs) need to be well characterized.
Guide decisions during cell line development with more information at the intact level by Roxana McCloskey | 0 CommentsMonitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to provide more information, it is possible to improve product quality and manufacturing efficiency and make more informed decisions.
Maximize NPS analysis with accurate mass spectrometry by Pierre Negri | 0 CommentsLC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many advantages, including the ability to reliably detect new drugs and their metabolites from a variety of biological matrices.
Unlock the benefits of nominal mass spectrometry for NPS analysis by Pierre Negri | 0 CommentsThe development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and the quality of the results. They also need robust and sensitive instrumentation that can detect drugs at trace levels with high specificity, especially when it comes to novel psychoactive substances (NPS), which can be difficult to monitor and control.
Detecting low levels of drugs and their metabolites in hair and nail samples using LC-MS/MS by SCIEX Community | Blogs, Forensic, ToxicologyYou probably have heard of testing blood and urine samples for the presence of drugs and their metabolites. But do you know about the benefits of hair and nail analysis? In a recent webinar, Tina Binz, Deputy Head of the Center for Forensic Hair Analysis, University of Zurich, discussed the benefits of developing comprehensive and sensitive LC-MS/MS for the detection of low-level drugs and metabolites in keratinized matrices.
LC-MS system replacement: Are you ready? by Kirsten Craven | Blogs, Pharma, QTRAP / Triple QuadMeeting deadlines in a bioanalysis laboratory can be a big challenge. Older, less sensitive and less reliable LC-MS systems make it even more difficult. Even the disruption caused by the installation and validation can be disconcerting and delay decisions. Does this sound familiar?
An overview: LC-MS analysis of targeted protein degraders and their metabolites by Kirsten Craven | Blogs, Pharma, ZenoTOF 7600 systemTargeted protein degraders (TPD) are a relatively new therapeutic modality that opens the potential to target disease-causing proteins. These disease-causing proteins have been highly challenging for traditional small-molecule therapeutics to treat, making TPDs an exciting new therapeutic modality.
Questions and answers to help improve your mycotoxin analysis by Michael Zellmann | Blogs, Food / Beverage, Food and BeverageDuring a recent webinar I shared method details for mycotoxin analysis on the SCIEX 7500 system. In this blog i will share the Q&A for the submitted questions that we did not have chance to answer during the live webinar.
A new approach for comprehensive AAV evaluation including full and empty analysis by Kerstin Pohl | Biopharma, BioPhase 8800 system, BlogsCertain next-gen vaccines and gene therapy applications rely on the usage of adeno-associated viruses (AAV) as a delivery vehicle. To ensure the safety and efficacy of viral vector drugs, multiple critical quality attributes (CQAs) need to be well characterized.
Guide decisions during cell line development with more information at the intact level by Roxana McCloskey | Biopharma, Blogs, Intabio ZT system, ZenoTOF 7600 systemMonitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to provide more information, it is possible to improve product quality and manufacturing efficiency and make more informed decisions.
Maximize NPS analysis with accurate mass spectrometry by Pierre Negri | Blogs, Forensic, SCIEX OS software, Toxicology, ZenoTOF 7600 systemLC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many advantages, including the ability to reliably detect new drugs and their metabolites from a variety of biological matrices.
Unlock the benefits of nominal mass spectrometry for NPS analysis by Pierre Negri | Blogs, Clinical, Forensic, QTRAP / Triple Quad, ToxicologyThe development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and the quality of the results. They also need robust and sensitive instrumentation that can detect drugs at trace levels with high specificity, especially when it comes to novel psychoactive substances (NPS), which can be difficult to monitor and control.
Acoustic Ejection Mass Spectrometry at ASMS 2023 by Christie Hunter | Echo® MS+ system, SCIEX information, TechnologyFor all those interested in learning about all the cool applications possible with AEMS and the Echo MS system, here is a list of presentations at ASMS 2023. Monday: MOH 3:50pm – Intact protein analysis MP 294 – Metabolite identification MP 312 Compound QC Tuesday TOB...
Clustering algorithms in MarkerView App by Christie Hunter | Data Visualization, Life Science Research, Multi-Omics, OneOmics, Proteomics, SCIEX informationFinding interesting and significant changes across a biological dataset can be challenging, so having good algorithms that can mine large datasets for differences, and find the statistically significant changes is really important. Within the MarkerView App we have...