Kirsten Craven

LC-MS system replacement: Are you ready?

Aug 16, 2024 | Blogs, Pharma, QTRAP / Triple Quad | 0 comments

Read time: 2 minutes

Meeting deadlines in a bioanalysis laboratory can be a big challenge. Older, less sensitive and less reliable LC-MS systems make it even more difficult. Even the disruption caused by the installation and validation can be disconcerting and delay decisions. Does this sound familiar?

Let’s break down the process and potential benefits of a regulated laboratory. The biggest challenge is usually the software installation and validation. To streamline this step, the Change Control support plan from SCIEX helps customers who require revalidation of their software to mitigate risk for software and hardware system assessments. Collaborate with us to integrate new software features seamlessly, bolster system security, enhance performance and ensure compatibility.

Is it time … for more reliability?

High system robustness enables analysis of large-scale sample sets

Learn how the robustness of the QTRAP 6500+ system ensures a smooth analysis of gut metabolites in plasma even with a high number of samples, complex matrices and challenging excipients.

Is it time … for more sensitivity?

Highly sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma

Fluticasone propionate, a synthetic glucocorticoid with potent anti-inflammatory activity, requires very sensitive assays to monitor pharmacokinetic parameters due to the very low therapeutic inhaled dose ranges. This need has led us to use large sample volumes. Here, a selective, sensitive and reproducible bioanalytical method was developed for quantitation of fluticasone propionate (LLOQ of 200 fg/mL) in human plasma using the QTRAP 6500 system. Reduced sample volume (500 µL plasma) and a final reconstitution volume of 200 µL for reinjection of samples or repeat analysis chromatography if required in a GLP laboratory.

Is it time … to reduce operational costs?

SCIEX OS software allows you to upgrade to a dry roughing pump configuration, you can expand your productivity and save money at the same time.

Why SCIEX partners with experts around the world

Innovation in mass spectrometry does not happen in isolation. Some of the most impactful scientific advances emerge from highly specialized research communities – proteomics experts developing new peptide identification workflows, metabolomics researchers curating spectral databases, toxicologists building compound libraries, and biopharma scientists creating novel characterization methods.

Managing ADC characterization: The challenge of turning complexity into confidence

Unlike traditional monoclonal antibodies, ADCs combine an antibody backbone with linker chemistry and a cytotoxic payload. This multi-component architecture introduces overlapping layers of heterogeneity, including drug-to-antibody ratio (DAR) distributions, charge variants, post-translational modifications, and structural changes at both the intact and subunit levels. Across ADC development, these characteristics are considered critical quality attributes that must be characterized, understood, and monitored.

3 reasons ZT Scan DIA is changing the game in metabolomics

For years, metabolomics researchers have faced a frustrating reality: modern high-resolution mass spectrometers can detect tens of thousands of molecular features, yet only a fraction can be confidently identified. The challenge is no longer finding molecules. It is generating the high-quality MS/MS data needed to confidently assign structures and extract meaningful biological insights.

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Kirsten Craven

Kirsten Craven is the Senior Global Marketing Manager for Pharma global strategic marketing at SCIEX. In this role, she manages strategic marketing for the pharmaceutical industry. Kirsten spent the first part of her career working in laboratories across multiple industries before moving into product management, and most recently pharma marketing.

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