Kirsten Craven

LC-MS system replacement: Are you ready?

Aug 16, 2024 | Blogs, Pharma, QTRAP / Triple Quad | 0 comments

Read time: 2 minutes

Meeting deadlines in a bioanalysis laboratory can be a big challenge. Older, less sensitive and less reliable LC-MS systems make it even more difficult. Even the disruption caused by the installation and validation can be disconcerting and delay decisions. Does this sound familiar?

Let’s break down the process and potential benefits of a regulated laboratory. The biggest challenge is usually the software installation and validation. To streamline this step, the Change Control support plan from SCIEX helps customers who require revalidation of their software to mitigate risk for software and hardware system assessments. Collaborate with us to integrate new software features seamlessly, bolster system security, enhance performance and ensure compatibility.

Is it time … for more reliability?

High system robustness enables analysis of large-scale sample sets

Learn how the robustness of the QTRAP 6500+ system ensures a smooth analysis of gut metabolites in plasma even with a high number of samples, complex matrices and challenging excipients.

Is it time … for more sensitivity?

Highly sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma

Fluticasone propionate, a synthetic glucocorticoid with potent anti-inflammatory activity, requires very sensitive assays to monitor pharmacokinetic parameters due to the very low therapeutic inhaled dose ranges. This need has led us to use large sample volumes. Here, a selective, sensitive and reproducible bioanalytical method was developed for quantitation of fluticasone propionate (LLOQ of 200 fg/mL) in human plasma using the QTRAP 6500 system. Reduced sample volume (500 µL plasma) and a final reconstitution volume of 200 µL for reinjection of samples or repeat analysis chromatography if required in a GLP laboratory.

Is it time … to reduce operational costs?

SCIEX OS software allows you to upgrade to a dry roughing pump configuration, you can expand your productivity and save money at the same time.

Sterile but toxic: Cereulide detection in food matrices

In a recent webinar, Ming Gao, Ph.D., Senior Research Chemist at Mérieux NutriSciences, explored the growing challenge of cereulide contamination in food products and the analytical strategies needed to detect this heat-stable toxin at trace levels. The session examined how LC-MS/MS can help laboratories overcome the limitations of traditional microbiological screening and meet emerging regulatory requirements.

How SCIEX Now empowers mass spec users to work with more control, clarity and confidence

In this interview, Andy Wilcox, Senior Market Development Manager, Aftermarket and Software, speaks with Susanna Baqué, Senior Director of Global Customer Experience, about how SCIEX Now gives customers one connected digital workspace to manage instruments, reduce time spent searching for information, resolve issues faster and keep their laboratory running more efficiently and with greater confidence.

Bioanalysis across modalities: Advancing confident decisions with modern LC‑MS strategies

As therapeutic pipelines continue to diversify, bioanalysis is being asked to do more than ever before. From small molecules to complex biologics, today’s scientists must generate high‑quality, reliable data across a growing range of molecule types and workflows, often under increasing time pressure.

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Kirsten Craven

Kirsten Craven is the Senior Global Marketing Manager for Pharma global strategic marketing at SCIEX. In this role, she manages strategic marketing for the pharmaceutical industry. Kirsten spent the first part of her career working in laboratories across multiple industries before moving into product management, and most recently pharma marketing.

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