Unlock the benefits of nominal mass spectrometry for NPS analysis by Pierre Negri | 0 CommentsThe development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and the quality of the results. They also need robust and sensitive instrumentation that can detect drugs at trace levels with high specificity, especially when it comes to novel psychoactive substances (NPS), which can be difficult to monitor and control.
Jon MacGregor by Jon MacGregor | 0 CommentsI have a turbo v ion source that shows a glowing blue/purple light at the tip of the Heated Nebulizer corona discharge needle, even when it is not in use and turned out of ion path as it should be when using TIS probe. It only happens in negative mode. It is not arcing to the cutain plate, just a slight noticeable glow at the tip of the corona needle when observed through the front window. My FSE has rebuilt the HN probe and components and also installed a new TIS probe. Still glows when in negative mode. Note also having poor sensitivity in negative mode as well and jagged peak shapes during infusion. Any ideas? Are the symptoms related?
Using Scheduled Ionization to reduce system ion load for proteomics data acquisition by Alexandra Antonoplis | 0 CommentsWhen analyzing highly complex samples from biological matrices, there can be significant amounts of material that elute in the wash cycle of the LC run, depending on the up-front sample preparation used. The Scheduled Ionization mode, available in both SCIEX OS...
How to optimize sample plating to run Echo MS system in ‘Fast acquisition mode’ by Mackenzie Pearson | 0 CommentsThe Echo MS system can acquire data extremely rapidly, at 1 second per sample. To achieve this speed, it should be ensured that there is adequate time between ejections for the analyte signal to return to baseline between ejections. Plating your samples such that you...
Unlock the benefits of nominal mass spectrometry for NPS analysis by Pierre Negri | Blogs, Clinical, Forensic, QTRAP / Triple Quad, ToxicologyThe development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and the quality of the results. They also need robust and sensitive instrumentation that can detect drugs at trace levels with high specificity, especially when it comes to novel psychoactive substances (NPS), which can be difficult to monitor and control.
Using Scheduled Ionization to reduce system ion load for proteomics data acquisition by Alexandra Antonoplis | Data acquisition, Ion sources, Life Science Research, Proteomics, QTOF, QTRAP / Triple Quad, SCIEX information, SCIEX OS software, ZenoTOF 7600 systemWhen analyzing highly complex samples from biological matrices, there can be significant amounts of material that elute in the wash cycle of the LC run, depending on the up-front sample preparation used. The Scheduled Ionization mode, available in both SCIEX OS...
How to optimize sample plating to run Echo MS system in ‘Fast acquisition mode’ by Mackenzie Pearson | Data acquisition, Echo MS, Optimizing Performance, Pharma, SCIEX information, TechnologyThe Echo MS system can acquire data extremely rapidly, at 1 second per sample. To achieve this speed, it should be ensured that there is adequate time between ejections for the analyte signal to return to baseline between ejections. Plating your samples such that you...
Standard addition workflow – for quantification and calculating background levels by April Quinn-Paquet | Bioanalysis/PK, Data processing, Pharma, QTOF, QTRAP / Triple Quad, SCIEX information, SCIEX OS software, Technology, ZenoTOF 7600 systemThe method of standard addition is a quantitative analysis approach used in situations where matrix effects from complex samples contributes to the analytical signal. This makes it impossible to compare the analytical signal between sample and standard using a...
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready by Jianru Stahl-Zeng | Blogs, ClinicalSensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
A rising star in food allergen research: proteomics of shellfish allergen by SCIEX Community | Blogs, Food / Beverage, Life Science Research, ProteomicsIt’s important to know what you’re eating, especially if you suffer from a food allergy. About 220 million people worldwide live with a food allergy.1 These numbers, along with the complexity and severity of conditions, continue to rise. In America, there are about 32 million food allergy sufferers—5.6 million of those are children under the age of 18.2.2 That’s 1 out of every 13 children, or about 2 in every classroom. From a financial perspective, the cost of food allergy childcare for US families is up to $25 billion