Fentanyl is one of the most well-known synthetic opioids that has been in the spotlight lately—and not for good reasons. The World Drug Report 2019 reveals that there have been more than 47,000 opioid overdose deaths in the United States in 2017. This is an increase...
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An overview: LC-MS analysis of targeted protein degraders and their metabolites
Targeted protein degraders (TPD) are a relatively new therapeutic modality that opens the potential to target disease-causing proteins. These disease-causing proteins have been highly challenging for traditional small-molecule therapeutics to treat, making TPDs an exciting new therapeutic modality.
Guide decisions during cell line development with more information at the intact level
Monitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to provide more information, it is possible to improve product quality and manufacturing efficiency and make more informed decisions.
Processing ZenoTOF 7600 system data with DIA-NN software
DIA-NN software is a powerful software tool for processing data independent acquisition (DIA) proteomics datasets. It uses neural networks and other algorithms to identify and quantify peptides and proteins from DIA data and is specifically optimized for fast...
Meat vs plant based. What is the best option?
As we become more conscious about the planet, healthier lifestyles and our duty to protect the environment, attitudes and behaviours are shifting when it comes to food consumption.
How is the protein level fold-change computed on proteomics data using Assembler app?
With bottom-up proteomics, we quantify peptides in the sample and then infer the protein level quantitation from that data. However, due to post-translational modifications, different protein isoforms, etc. we don’t always expect that all peptides associated with the...
Computing protein confidence with improved accuracy by reassessing peptide confidence during protein grouping
ProteinPilot software 4.0 and higher releases include a new method for calculating protein confidences that improves reliability at the end of protein lists. Figure 1 shows a simulated example that demonstrates how more accurate protein confidence is computed. Figure...
Intabio acquisition expands SCIEX portfolio of impactful solutions to accelerate biotherapeutic development
Due to the nature of their production, biotherapeutics are difficult to manufacture. Growth conditions, purification protocols and formulation requirements can introduce unintended modifications into the protein structure that may affect its efficacy and safety.
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
The honey sting
As a consumer it’s hard for me not to feel inundated with claims that our food is “all-natural” or “chemical-free” or that we should buy certain “superfoods” for their health benefits. We read labels and trust that the product we are buying is what we are truly...
Innovation that’s blasting through limitations in explosive detection
Mass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
6 Tips to Keep Your Lab’s Software Up and Running
6 Tips to Keep Your Lab’s Software Up and Running Is your lab utilizing SCIEX instrumentation but hesitant about upgrading to the latest software release? Perhaps you are uncertain about key features, error codes, or output. Not to worry, behind every great mass...
A Smart Way to Profit from the Wealth of Biobanks
Microflow LC with SWATH® Acquisition for Digitizing Biobanks What if you could access thousands of high-quality samples for your research? What if these samples were well-annotated biological specimens? And what if they were carefully segmented into just the...
Why Conventional Flow LC-MS/MS Bioanalysis Is out and Microflow Is In
New technologies can transform a laboratory’s throughput and efficiency. At Alturas, if we try out a new technology, we ask: Does it work? Is it convenient? Is it rugged? Are we getting good results? When we look at the convenience, uptime, and overall data that we’re...
Food Testing Labs: What Technology Is Right for You?
Consumer safety is the driving force behind food analysis. From field (or ocean) to fork, there are numerous opportunities for food to become potentially hazardous to human health. As fast as new contaminants enter the food chain, changes in regulation and legislation...
Fueling Up: Eating To Stay Strong When You Have Cancer
This is the third and final post in our series in honor of International Women’s Day and our collaboration with World Cancer Research Fund. To wrap up, Deborah Howland talks about the importance of diet for anyone facing cancer – or trying to prevent it. A specialist...
5 Demands of Forensic Toxicologists and the Ultra-Fast Method That Meets Them
There just isn’t a screening approach available that can give us everything we need when throughput is the priority. Sound familiar? For many toxicology labs, there is a misconception that compromises need to be made when it comes to high throughput drug screening....
Global Trends That Will Affect Neonicotinoid Usage in 2019
Neonicotinoids have become the most widely used class of insecticide in the world, with registration in 120 countries. However, these pesticides have become embroiled in multi-year controversy in Europe and North America due to their risk to beneficial...
A Diagnosis And A “Difficult Waiting Game”
We are thrilled to mark International Women’s Day 2019 by making our fourth annual donation to World Cancer Research Fund, a global not-for-profit organization and leading authority on the links between diet, nutrition, physical activity, and cancer. In fact, our...
Phthalates: The Everywhere Chemical That’s Hard to See, Not Anymore with LC-MS/MS
A few months back, the American Academy of Pediatrics published a technical report on the use of chemicals in food processing and the negative health effects on children. One of the main culprits is phthalates. The 411 of PhthalatesPhthalates are esters of phthalic...
The SCIEX Software Roadmap – The Journey Towards Windows 10 Compatibility is Complete
At SCIEX we are committed to providing you with the most up-to-date tools and technologies to meet the evolving needs of the laboratory. As part of that commitment, we were introducing our software product roadmap towards Windows 10 compatibility back in 2017. Many of...
10 Minutes in One Shot. That’s How Quickly You Can Screen 664 Forensics Compounds
Drug testing is a moving target. As novel psychoactive substances (NPS) rapidly emerge as a new class of designer stimulants (DS), global use has reached an all-time high over the last decade. Supposedly ‘legal’ alternatives to internationally controlled drugs, these...
Turbocharge THC-COOH Hair Analysis with Super Sensitive LC-MS/MS and Solid Phase Extraction
Do you want a more efficient workflow for the forensic analysis of THC-COOH in hair samples? Yes! Do we know a simple, highly sensitive technique? You bet! Read on to find out how you can detect THC-COOH in hair down to 0.2 pg/mg trace concentration levels with...
Fast Novel Psychoactive Substance Testing, At Your Fingertips
Why Dried Blood Spot Analysis Is the Way to Go for Novel Psychoactive Substances(And Why You Need This SCIEX LC-MS/MS Method) Anyone with children will remember that moment in the hospital when the nurse pricks the heel of your tiny new baby to squeeze out a few drops...
Take 5 with Dan Blake – 5 Minutes, 5 Questions on the World of Clinical Mass Spec
We would like to formally (or informally) introduce the new SCIEX Clinical Diagnostics blog series entitled, Take 5. Every couple of months we will ask a member of our team to answer five questions and share their responses in a format you can read in five minutes. We...
The Technology Behind Safe, Legal Cannabis
The Third in a Three-Part Series Part 1: Cannabis is Legal in Canada - How Did We Get Here? Part 2: Canada's Focus on Cannabis Quality and Safety Intensifies Welcome to the third in a series of blogs from the cannabis team at SCIEX, designed to bring you up to speed...
What is Multi Attribute Methodology (MAM)?
Q&A with Sean McCarthy Global Market Manager, Biologics, SCIEX MAM is an acronym for Multiple Attribute Method. In short, MAM is a method which may be applied for characterization of a biotherapeutic to understand its sequence, identify liabilities, identify...
New Methods for N-Glycan Sequencing Provide Structural Information in as Little as 1 Hour
As interest in N-glycan analysis grows within the biopharma industry, innovation continues allowing analyses to be done in less time with fewer and less tedious, sample preparation steps. One of these recent innovations was the release of the SCIEX Fast Glycan...
When Chiral Separation Turns Tricky: The Story Behind CESI-MS in Forensic Chiral Analysis
Against a backdrop of rapid growth, chirality plays a major role in the synthesis of drugs in both pharmaceutical and illicit drug development. In fact, more than half of the drugs currently in use are chiral compounds, available as either racemates or pure...
Cannabis is Legal in Canada – How Did We Get Here?
The First in a Three-Part Series Welcome to the first in a series of blogs from the cannabis team at SCIEX, designed to bring you up to speed and put you in the lead of the recently legalized cannabis market in Canada. The Canadian cannabis market has taken the plunge...
3 Dicamba Analysis Questions You Need to Ask Yourself Today
We blinked and the last two years went in a flash. It seems like just yesterday, the Dicamba herbicide controversy hit the headlines in 2016 and the EPA set the regulations to expire in two years. Fast forward to today. Dicamba is an acid herbicide used to kill...