In our last blog, I gave you some current highlights about the mysterious vaping illness that was making headlines (and still is). The condition now known as, e-cigarette or vaping, product use-associated lung injury (EVALI) has sickened thousands and killed 57...
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ADC analytics FAQs: Answering the most common questions about ADC characterization
Antibody-drug conjugates (ADCs) have emerged as one of the fastest-growing classes of biotherapeutics, combining the targeting specificity of monoclonal antibodies with the potency of cytotoxic payloads. However, this unique architecture also introduces significant analytical complexity. From drug-to-antibody ratio (DAR) distributions and charge variants to conjugation sites and structural modifications, ADCs present multiple, interconnected sources of heterogeneity that must be understood to ensure product quality and performance.
Advanced analytics for mAb variants
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Breaking down the SCIEX 7500 system
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
The honey sting
As a consumer it’s hard for me not to feel inundated with claims that our food is “all-natural” or “chemical-free” or that we should buy certain “superfoods” for their health benefits. We read labels and trust that the product we are buying is what we are truly...
Innovation that’s blasting through limitations in explosive detection
Mass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
A new generation of therapeutic modalities
There are over 7,000 genetic diseases that could potentially be cured using gene therapy. Rare metabolic diseases, autoimmune disorders, cardiovascular disease and cancers are some of the top disease classes that can be addressed with gene therapies. With over 1,000...
Enhancing Biologics with CESI-MS Characterization
Comprehensive characterization of a biologic requires analysis at both the intact and digest levels, but these analyses can be complex and cumbersome. For example, with conventional liquid chromatography separations, researchers are often left with limited information...
Full, partial and empty capsid ratios for AAV analysis: What’s the big deal?
For many of you working to develop gene therapy drugs, you know that the time to market the drug is critical. Because gene therapeutics cure diseases by targeting specific genes, it is a constant race to see who develops the drug first. Unlike other classes of drugs where multiple medications can be used to treat a disease, whoever is first to develop a gene therapy drug wins.
Accurate mass LC-MS/MS for PFAS analysis without needing a blockbuster budget
If you’ve been following our recent blogs, you’ve probably seen quite a bit on how per- and polyfluoroalkyl substances (PFAS) are shaking up both the food and environmental industry. Even if you’ve not been following our blogs, you’ve probably seen a lot of media...
A rising star in food allergen research: proteomics of shellfish allergen
It’s important to know what you’re eating, especially if you suffer from a food allergy.
About 220 million people worldwide live with a food allergy.1 These numbers, along with the complexity and severity of conditions, continue to rise. In America, there are about 32 million food allergy sufferers—5.6 million of those are children under the age of 18.2.2 That’s 1 out of every 13 children, or about 2 in every classroom. From a financial perspective, the cost of food allergy childcare for US families is up to $25 billion
The Advantages of a Software Maintenance Agreement
You’ve bought your mass spectrometer. You’ve installed all your hardware. You’ve got your operating software set up. You’ve mastered your software workflow modules to optimize quantitative and qualitative data processing. That’s it, right? Even though your system is...
You’ve Edited the Gene. Now What?
Protein-Level Verification Without The Need For Antibodies Using SWATH® Acquisition. Fast, Comprehensive, and Highly Reproducible Although humans have been able to influence the traits of plants and animals for thousands of years through domestication and selective...
Environmental Scientists: Here’s Why You Should Consider Nominal Mass Spectrometry for Your Routine PFAS and Gen-X Testing in Drinking Water
How are you feeling about PFAS regulation right now? If you’re like us, you probably find it hard to pinpoint one specific feeling. But if we took a look at the current state of affairs, we’d all probably agree that it’s a minefield of uncertainty. Under the Safe...
Why Quant?
Every decision you make requires a number As a pharmaceutical scientist, you understand the challenges in getting a new drug through the discovery and development pipeline. As an innovation partner in mass spectrometry, SCIEX works continuously with you, our...
6 Tips to Keep Your Lab’s Software Up and Running
6 Tips to Keep Your Lab’s Software Up and Running Is your lab utilizing SCIEX instrumentation but hesitant about upgrading to the latest software release? Perhaps you are uncertain about key features, error codes, or output. Not to worry, behind every great mass...
A Smart Way to Profit from the Wealth of Biobanks
Microflow LC with SWATH® Acquisition for Digitizing Biobanks What if you could access thousands of high-quality samples for your research? What if these samples were well-annotated biological specimens? And what if they were carefully segmented into just the...
Why Conventional Flow LC-MS/MS Bioanalysis Is out and Microflow Is In
New technologies can transform a laboratory’s throughput and efficiency. At Alturas, if we try out a new technology, we ask: Does it work? Is it convenient? Is it rugged? Are we getting good results? When we look at the convenience, uptime, and overall data that we’re...
Food Testing Labs: What Technology Is Right for You?
Consumer safety is the driving force behind food analysis. From field (or ocean) to fork, there are numerous opportunities for food to become potentially hazardous to human health. As fast as new contaminants enter the food chain, changes in regulation and legislation...
Fueling Up: Eating To Stay Strong When You Have Cancer
This is the third and final post in our series in honor of International Women’s Day and our collaboration with World Cancer Research Fund. To wrap up, Deborah Howland talks about the importance of diet for anyone facing cancer – or trying to prevent it. A specialist...
5 Demands of Forensic Toxicologists and the Ultra-Fast Method That Meets Them
There just isn’t a screening approach available that can give us everything we need when throughput is the priority. Sound familiar? For many toxicology labs, there is a misconception that compromises need to be made when it comes to high throughput drug screening....
Global Trends That Will Affect Neonicotinoid Usage in 2019
Neonicotinoids have become the most widely used class of insecticide in the world, with registration in 120 countries. However, these pesticides have become embroiled in multi-year controversy in Europe and North America due to their risk to beneficial...
A Diagnosis And A “Difficult Waiting Game”
We are thrilled to mark International Women’s Day 2019 by making our fourth annual donation to World Cancer Research Fund, a global not-for-profit organization and leading authority on the links between diet, nutrition, physical activity, and cancer. In fact, our...
Phthalates: The Everywhere Chemical That’s Hard to See, Not Anymore with LC-MS/MS
A few months back, the American Academy of Pediatrics published a technical report on the use of chemicals in food processing and the negative health effects on children. One of the main culprits is phthalates. The 411 of PhthalatesPhthalates are esters of phthalic...
The SCIEX Software Roadmap – The Journey Towards Windows 10 Compatibility is Complete
At SCIEX we are committed to providing you with the most up-to-date tools and technologies to meet the evolving needs of the laboratory. As part of that commitment, we were introducing our software product roadmap towards Windows 10 compatibility back in 2017. Many of...
10 Minutes in One Shot. That’s How Quickly You Can Screen 664 Forensics Compounds
Drug testing is a moving target. As novel psychoactive substances (NPS) rapidly emerge as a new class of designer stimulants (DS), global use has reached an all-time high over the last decade. Supposedly ‘legal’ alternatives to internationally controlled drugs, these...
Turbocharge THC-COOH Hair Analysis with Super Sensitive LC-MS/MS and Solid Phase Extraction
Do you want a more efficient workflow for the forensic analysis of THC-COOH in hair samples? Yes! Do we know a simple, highly sensitive technique? You bet! Read on to find out how you can detect THC-COOH in hair down to 0.2 pg/mg trace concentration levels with...
Fast Novel Psychoactive Substance Testing, At Your Fingertips
Why Dried Blood Spot Analysis Is the Way to Go for Novel Psychoactive Substances(And Why You Need This SCIEX LC-MS/MS Method) Anyone with children will remember that moment in the hospital when the nurse pricks the heel of your tiny new baby to squeeze out a few drops...
Take 5 with Dan Blake – 5 Minutes, 5 Questions on the World of Clinical Mass Spec
We would like to formally (or informally) introduce the new SCIEX Clinical Diagnostics blog series entitled, Take 5. Every couple of months we will ask a member of our team to answer five questions and share their responses in a format you can read in five minutes. We...
The Technology Behind Safe, Legal Cannabis
The Third in a Three-Part Series Part 1: Cannabis is Legal in Canada - How Did We Get Here? Part 2: Canada's Focus on Cannabis Quality and Safety Intensifies Welcome to the third in a series of blogs from the cannabis team at SCIEX, designed to bring you up to speed...
What is Multi Attribute Methodology (MAM)?
Q&A with Sean McCarthy Global Market Manager, Biologics, SCIEX MAM is an acronym for Multiple Attribute Method. In short, MAM is a method which may be applied for characterization of a biotherapeutic to understand its sequence, identify liabilities, identify...