by Michael Zellmann | May 1, 2024 | Blogs, Food / Beverage, Food and Beverage
Read time: 3 minutes During a recent webinar I shared method details for mycotoxin analysis on the SCIEX 7500 system. In this blog i will share the Q&A for the submitted questions that we did not have chance to answer during the live webinar. What were the...
by Kerstin Pohl | Apr 29, 2024 | Biopharma, Blogs, Pharma, QTOF, QTRAP / Triple Quad, ZenoTOF 7600 system
Read time: 10 minutes In 1998, the US Food and Drug Administration (FDA) approved fomivirsen as the first therapeutic oligonucleotide therapeutic. This approval marked a revolution of mechanism of action discovered decades before finally coming to fruition. Since...
by Kirsten Craven | Apr 25, 2024 | Blogs, LC, Pharma
Read time: 3 minutes The dream state If we lived in an ideal world, it would be possible to unambiguously identify metabolites using a single analytical experiment. This analytical technique would need to be efficient and easily generate the information needed from a...
by Kerstin Pohl | Apr 17, 2024 | Biopharma, Blogs, PA 800 system
Read time: 7 minutes Prime editing (PE) is a next-generation gene editing technology that utilizes a Cas9 protein fused to a prime editing guide ribonucleic acid (pegRNA) to achieve high CRISPR/Cas9 editing efficiency and precision. However, the length requirement of...
by Kerstin Pohl | Apr 16, 2024 | Biopharma, BioPhase 8800 system, Blogs
Read time: 6 minutes Certain next-gen vaccines and gene therapy applications rely on the usage of adeno-associated viruses (AAV) as a delivery vehicle. To ensure the safety and efficacy of viral vector drugs, multiple critical quality attributes (CQAs) need to be well...
by Gitte Barknowitz | Apr 4, 2024 | Agriculture, Blogs, Food / Beverage, Food and Beverage
Read time: 7 minutes Allergy policies for nut-free commercial flights and nut-free childcare settings are not a rare occurrence nowadays—the reason is a rise in food allergies. Nuts are the most potent allergenic foods in terms of the amount that is required to elicit...
by Roxana McCloskey | Mar 28, 2024 | Biopharma, Blogs, Intabio ZT system, ZenoTOF 7600 system
Read time: 5 minutes Monitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to...
by Kerstin Pohl | Mar 14, 2024 | Biopharma, BioPhase 8800 system, Blogs, ZenoTOF 7600 system
Read Time: 7 minutes Interviewee: Jane Luo (PhD), Senior Scientist, SCIEX Lipid nanoparticles (LNPs) are widely used vehicles for mRNA-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause...
by Pierre Negri | Mar 11, 2024 | Blogs, Forensic, SCIEX OS software, Toxicology, ZenoTOF 7600 system
Read time: 4 minutes LC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many...
by Pierre Negri | Mar 11, 2024 | Blogs, Clinical, Forensic, QTRAP / Triple Quad, Toxicology
The development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and...