Inside the box: Acoustic ejection mass spectrometry for drug discovery by Kirsten Craven | Feb 12, 2025 | Blogs, Discovery, Echo MS, Pharma, QA/QCOn average, it takes 10-15 years and 1-2 billion dollars to approve a new pharmaceutical for clinical use. Since approximately 90% of new drug candidates fail in clinical development, the ability to make early, informed and accurate decisions on the safety and efficacy of new hits and leads is key to increasing the chances of success.
Inside the box: Complementary fragmentation with LC-MS for Metabolite Identification by Kirsten Craven | Feb 7, 2025 | Blogs, Pharma, ZenoTOF 7600 systemLiquid chromatography-mass spectrometry is commonly used for Met ID but confident soft spot identification is not always possible. Imagine the advantage of unambiguous metabolite identification using liquid chromatography-mass spectrometry (LC-MS) reducing the need for additional safety testing during drug discovery. Quickly and easily generate the information you need using routine assays that are robust and efficient, enabling confident decision-making while also saving time and money.
The whys behind the dos and don’ts of oligonucleotide analysis by Kerstin Pohl | Feb 1, 2025 | Biopharma, Blogs, PharmaWe know that LC-MS oligonucleotide analysis can have its share of challenges—challenges with sensitivity, challenges with adduct formation and challenges with data analysis, to name just a few. That’s why this blog takes a closer look at the dos and don’ts of this type of analysis and explores some keys to success. It also explains why following these simple rules can vastly improve your oligonucleotide characterization and quantitation efficiency and success.
Pharma perspectives: The influence of LC-MS innovation on drug development outsourcing by Kean Woodmansey | Jan 13, 2025 | Blogs, Pharma, ZenoTOF 7600 systemIt is no secret that (bio)pharmaceutical research and development is complex, both scientific and regulatory processes. Working for a contract research organization and more recently for SCIEX has provided an interesting perspective on trends the market experiences that affect many of us.
Selecting an LC-MS system for quantitation of pharmaceutical drug development by Kirsten Craven | Oct 29, 2024 | Blogs, Echo MS, Pharma, QTRAP / Triple Quad, ZenoTOF 7600 systemWe understand you are busy, needing to prioritize running instruments, reporting results and managing your laboratory to meet deadlines. We created a solution guide to explain how SCIEX systems fit in the drug development pipeline to save you time evaluating options.
Nitrosamines: Where are we now? by SCIEX Community | Oct 10, 2024 | Blogs, Pharma, QTRAP / Triple QuadNitrosamines are a large group of N-nitroso compounds that share a common functional N-N=O group. They are produced by a chemical reaction between a nitrosating agent and a secondary or tertiary amine. Back in 2018, nitrosamines suddenly found themselves in the spotlight when they were unexpectedly detected in medications for high blood pressure. Since then, they have been found in several other prescription medications, including those for heartburn, acid reflux and diabetes, resulting in manufacturers recalling some common medications.
Celebrating customer experience: Insights from SCIEX leaders by Philip Taylor | Oct 1, 2024 | Biopharma, Blogs, Clinical, Environmental / Industrial, Food / Beverage, Forensic, Life Science Research, Pharma, TechnologyIntroduction Customer Experience Day (CX Day) is a special occasion for SCIEX, celebrated every first Tuesday in October. It’s a day dedicated to recognizing the incredible value of our customers and the relentless dedication of our associates who strive to make...
Your success and voice go a long way! by Philip Taylor | Sep 25, 2024 | Biopharma, Blogs, Clinical, Environmental / Industrial, Food / Beverage, Forensic, Life Science Research, Pharma, TechnologyAt the heart of everything we do is ensuring that your workflows and team are empowered to achieve optimal results with your SCIEX instruments, software, consumables, and services. Every interaction with SCIEX is designed to support your success through the dedication...
LC-MS system replacement: Are you ready? by Kirsten Craven | Aug 16, 2024 | Blogs, Pharma, QTRAP / Triple QuadMeeting deadlines in a bioanalysis laboratory can be a big challenge. Older, less sensitive and less reliable LC-MS systems make it even more difficult. Even the disruption caused by the installation and validation can be disconcerting and delay decisions. Does this sound familiar?
An overview: LC-MS analysis of targeted protein degraders and their metabolites by Kirsten Craven | Aug 14, 2024 | Blogs, Pharma, ZenoTOF 7600 systemTargeted protein degraders (TPD) are a relatively new therapeutic modality that opens the potential to target disease-causing proteins. These disease-causing proteins have been highly challenging for traditional small-molecule therapeutics to treat, making TPDs an exciting new therapeutic modality.