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The pharmaceutical industry is facing an ongoing issue with genotoxic impurities (GTIs). Over the past year, we have witnessed genotoxic impurities affect several drugs, including those used to treat elevated blood pressure, heartburn and acid reflux. Angiotensin II...
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Want to accelerate your drug discovery workflow?
Bringing a new drug to market is a costly and complex process. With potentially hundreds of thousands of new compounds to screen during drug discovery, sample throughput is a common bottleneck for pharmaceutical companies. So how do you overcome this barrier?
Easing the demands of a compliant pharmaceutical laboratory
At SCIEX, we are proud to provide analytical systems to the pharmaceutical industry. We work hard to understand the demands of analytical work and the processes required to develop and manufacture drugs.
What has the Echo® MS system done for the pharma industry? (And don’t just take our word for it!)
SCIEX was very proud to have an illustration of the Acoustic Ejection Mass Spectrometry (AEMS) technology that powers the Echo® MS system on the front cover of the Journal of the American Society for Mass Spectrometry in January 2023. The associated article—Ultrahigh-Throughput Intact Protein Analysis with Acoustic Ejection Mass Spectrometry—was co-authored by scientists from SCIEX and Merck.
5 Reasons to choose the Echo® MS system for high-throughput drug discovery
Have you thought about introducing new technology into your high-throughput drug discovery lab? Here are 5 reasons the Echo® MS system could make a difference for you.
What have we learned from the nitrosamine crisis?
The pharmaceutical industry is facing an ongoing issue with genotoxic impurities (GTIs). Over the past year, we have witnessed genotoxic impurities affect several drugs, including those used to treat elevated blood pressure, heartburn and acid reflux. Angiotensin II...
Top 7 Echo® MS system customer questions—answered
You asked, we answered! With analysis speeds of at least 1 sample per second, the Echo® MS system has created a buzz in the industry. This is up to 50x faster than conventional LC-MS/MS. This revolutionary tool for drug discovery and development has led to...
An interview from the Science Explorer about the Echo® MS system
The Science Explorer interviews Neil Walsh from SCIEX to discuss the significant application areas of the Echo® MS System and what makes this system so attractive to biopharmaceutical laboratories.
Developing a method for nitrosamine analysis in pharmaceutical products
In our previous blogs we discussed the need for a more comprehensive approach for monitoring contaminants in finished drug products.1,2 Here we cover a generalized approach for the targeted, quantitative LC-MS/MS analysis of several commonly encountered nitrosamines in pharmaceuticals and ways to address specific challenges with their analysis.
The Echo® MS system: Is it reproducible? Yes… yes… yes!
The Echo® MS System is an exciting new platform that dramatically speeds sample analysis for quantitative MS studies. Because of its unique and innovative technology, the system can analyze samples faster than ever before—but without the need for LC.
Scale it up! The Echo® MS System delivers unprecedented levels of productivity
Imagine the productivity gains your lab could achieve with a technology that not only analyzes samples up to 50x faster than conventional quantitative LC-MS, but also eliminates tedious sample preparation, time-consuming LC method development and chromatographic run...
A Fleet of Analyzers Keeps Work Flowing
An Interview with Timothy Sangster, Head of Bioanalysis and Immunology, Charles River Laboratories, Edinburgh
Do You Want to Accelerate Quantitative Assays for Antibody Drug Conjugates?
Are you tasked with the bioanalysis of antibody drug conjugates (ADCs)? If so, you know they represent a rapidly growing class of biotherapeutics, but their unique chemical structure makes quantitative analysis particularly challenging.
The Only Solution You Need for Fast MetID
If you work in the breakneck world of therapeutic development, then you probably don’t even have time to read this blog (but we thought we would write it anyways, just in case). Drug metabolism samples are coming into your lab fast and furious. You need to turn them around in hours so that chemists and biologists can optimize the effectiveness of the therapeutic candidate. Time for lunch? We don’t think so!
The Application of Research Grade MetabolitePilot™ Software for the Determination of the Catabolic Peptide Products of Exenatide
The stability of peptide and protein biotherapeutics directly impacts their pharmacokinetic profile, efficacy, and safety. It is therefore essential to characterize the stability of a given bio-therapeutic including both in-vivo and in-vitro catabolism, thereby...
Superbugs, Antibiotic Resistance, and the QTRAP® 6500+ System
‘Superbugs’, or bacteria that have developed antibiotic resistance as a result of adapting to the drugs used in their treatment, are dangerous infections that doctors struggle to stop from spreading. Even common infections such as urinary tract infections and...
Drug Metabolism and Bioanalysis Journal Articles Focus on Drug Metabolism and so Much More
Check-out the top articles that focus on innovations in drug metabolism as well as small molecule quantitation and biologics bioanalysis. Exciting advancements! We can’t wait to see all that will come in 2016! Quantitative analysis of maytansinoid (DM1) in human serum...
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