Top Five Misconceptions about Mass Spectrometry by SCIEX Community | 0 CommentsDo you work in a lab handling precious samples yet, hesitant to make the move to mass spectrometry? Many laboratories just like yours continue to conduct sample analysis using ELISA assays, PCR scans, and amino acid tests because of their effectiveness. These processes work, so why change? Well, these type of analytical experiments can report false positive and negative results. You have trained your staff, know the process, and fingers crossed, not too many user errors have compromised analysis.
Stoller Biomarker Discovery Centre, Addressing Some of the Biggest Issues in Medicine by SCIEX Community | 0 CommentsThe Stoller Biomarker Discovery Center, developed in partnership with SCIEX, was created to develop new omics technologies for biomarker research to understand the root cause of diseases such as cancer, cardiovascular disease, and autoimmune diseases. We initially announced our collaboration with the University of Manchester back in October 2015.
Rapid Separation Method for Intact Monoclonal Antibodies (Mab) Merges Charge Variant, Impurity, and Glycoform Analyses into a Single Assay by Laura Baker | 0 CommentsThroughout all stages of development and manufacture, monoclonal antibodies (mAbs) exhibit a great deal of structural complexity. After translation and folding, proteins undergo post-translational modifications, as well as spontaneous and enzymatic degradation, such that a single preparation of purified mAb exhibits a range of small structural changes, composed of various glycoforms and charge variants, as well as amino acids alterations due to oxidation, deamidation, isomerization, or other chemical reactions. This display of structural heterogeneity can influence the overall stability, efficacy, and safety profile; therefore, understanding the extent of structural modifications has become extremely important to drug manufacturers who continually assess mAb composition throughout bioprocessing to demonstrate stability, batch-to-batch consistency, and long-term shelf life.
Glycosylation Analysis Designed for the (Protein) Masses by SCIEX Community | 0 CommentsA variety of post-translational modifications (PTMs) can impact a biotherapeutic protein’s mass, but none are as common as glycosylation.[1] Hence, the headline for a recent article in Genetic Engineering and Biotechnology News, “Post-Translational Icing on the Biologics Cake,” featuring comments from Sean McCarthy, Ph.D., Global Market Manager of Biologics at SCIEX.
Bulletproof your clinical laboratory with rugged and reliable LC-MS/MS instrumentation (Clinical diagnostic blog) by Pierre Negri | Blogs, Clinical, Ion sourcesThe ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
Bulletproof your clinical laboratory with rugged and reliable LC-MS/MS instrumentation (Clinical research blog) by Pierre Negri | Blogs, Clinical, Ion sourcesThe ability to consistently achieve reproducible results on many complex samples across multiple days is critical to a routine clinical laboratory. Laboratories relying on analytical instrumentation require stability and robustness to perform a variety of screening and confirmatory assays with confidence. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the preferred analytical method in the clinical laboratory to reliably perform clinical testing as it provides best-in-class performance and reliability for the most challenging assays. LC-MS/MS offers the required levels of sensitivity and specificity for the detection and quantitation of molecules from complex biological samples, helping laboratories deliver highly accurate data for a variety of clinically relevant analytes across a wide range of assays.
Methods for electrode cleaning for Echo MS systems by John Gibbons | Blogs, Echo® MS+ system, PharmaDepending on the samples that you are running on the system, it is possible for the Echo MS electrode to become dirty or occluded over time. Below are two different cleaning strategies that will be helpful for you to maintain your system and keep your electrodes running well.
The myth of costly training: debunked. by Andrea Mueller | Blogs, Instrument maintenance, Optimizing Performance, Technology, TrainingAs analytical organizations grow, there is an even greater need to train scientists and operators more consistently to meet tight deadlines, handle increasing samples, and meet data quality expectations. A high rate of employee turnover also affects the productivity of labs worldwide. Consistent training helps today’s labs stay competitive, whether the goal is sample throughput, therapeutic development, or publication.
PFAS regulations – a journey around the globe by Gitte Barknowitz | Blogs, Environmental / IndustrialA few years ago, I was plotting along in my analytical job and keeping up-to-date with residue regulations took a considerable amount of time, but it was always manageable. Nowadays, we have PFAS.
Tackling mycotoxin testing: Harnessing mass spectrometry for safer foods and healthier futures by SCIEX Community | Blogs, Food / Beverage, Food and BeverageProduced by certain moulds, thriving in crops such as grain, nuts and coffee, mycotoxins have contaminated agriculture and food production industries for a long time. To intensify the challenge, mycotoxins are resilient, not easily broken down and ensuring the safety of food supply chains requires comprehensive solutions and we are here to share those solutions with you.
Enhancing omics-based mass spectrometry workflows with Electron-Activated Dissociation (EAD) by Rebekah Sayers | Blogs, Life Science ResearchElectron-Activated Dissociation (EAD) is transforming the fields of metabolomics and lipidomics by providing enhanced fragmentation techniques that offer deeper insights into molecular structures. In September, Technology Networks hosted a webinar, “Enhancing Mass-Based Omics Analysis in Model Organisms,” featuring Dr. Valentina Calabrese from the Institute of Analytical Sciences at the University of Lyon. Valentina shared her insights on improving omics-based mass spectrometry analysis for toxicology studies using model organisms, particularly in metabolomics and lipidomics. This blog explores the additional functionalities EAD offers, its benefits in untargeted workflows, its incorporation into GNPS and molecular networking, and the future role it could play in these scientific domains.
The economics of food testing: A strategic perspective for laboratory managers by Philip Taylor | Blogs, Food / Beverage, Food and BeverageIn today’s rapidly evolving food industry, the role of food testing laboratories has never been more critical. Ensuring the safety, quality, and authenticity of food products is paramount, and this responsibility falls heavily on the shoulders of laboratory managers. The economics of food testing—encompassing everything from high-throughput pesticide screening to advanced research on alternative protein sources—plays a pivotal role in shaping the operational efficiency and financial health of these laboratories.
Six benefits of remote support every laboratory should know by Andrea Mueller | Biopharma, Blogs, Environmental / Industrial, Food / Beverage, Food and Beverage, Forensic, Instrument maintenance, Life Science Research, Optimizing Performance, Pharma, Service, Support, Technology, TrainingImagine having a tech expert at your fingertips to solve computer issues or a fitness trainer guiding you through workouts from the comfort of your home. In today’s fast-paced world, the ability to provide and receive service and support remotely is no longer a luxury but a necessity. Whether it’s troubleshooting a software issue, repairing a device, offering customer assistance, or enjoying the convenience of telehealth as a private individual, remote capabilities have revolutionized how businesses operate and how individuals get help
Advancing immunopeptidomics for pancreatic cancer research with ZT Scan DIA by Katherine Tran | Blogs, Life Science ResearchPancreatic cancer remains one of the most fatal types of cancer, and the rates of occurrences and mortalities continue to be on a global rise.1,2 Recent statistics have reported that the diagnosis of pancreatic cancer is the eighth most common type of cancer and...