Maximize NPS analysis with accurate mass spectrometry by Pierre Negri | 0 CommentsLC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many advantages, including the ability to reliably detect new drugs and their metabolites from a variety of biological matrices.
Optimized rolling collision energy curves for IDA and SWATH DIA for peptides by Christie Hunter | 5 CommentsDuring data dependent acquisition (DDA or IDA) or SWATH acquisition, the collision energy can be automatically adjusted according to the mass/charge and charge of the peptide. This dependency has been well characterized on our QTOF systems. By selecting rolling...
Switching between different LCs that communicate through ethernet and setting up the correct module IP address by Adrian Taylor | 0 CommentsDifferent LC options are supported in SCIEX OS software and Analyst software. Those that communicate through ethernet differ in their default IP addresses. In this community post, we will detail the LAN setup, configuring the IP address and subnet mask for LC...
Getting access to demo data and other files for learning the OneOmics suite by Alexandra Antonoplis | 0 CommentsIn order to help you get proficient in using the OneOmics suite workflows, we have provided some demo datasets along with numerous other valuable files and supporting information to help you get started. Once you get access to your SCIEX Cloud account and can view...
Maximize NPS analysis with accurate mass spectrometry by Pierre Negri | Blogs, Forensic, SCIEX OS software, Toxicology, ZenoTOF 7600 systemLC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many advantages, including the ability to reliably detect new drugs and their metabolites from a variety of biological matrices.
Optimized rolling collision energy curves for IDA and SWATH DIA for peptides by Christie Hunter | Data acquisition, Life Science Research, Proteomics, QTOF, SCIEX information, ZenoTOF 7600 systemDuring data dependent acquisition (DDA or IDA) or SWATH acquisition, the collision energy can be automatically adjusted according to the mass/charge and charge of the peptide. This dependency has been well characterized on our QTOF systems. By selecting rolling...
Switching between different LCs that communicate through ethernet and setting up the correct module IP address by Adrian Taylor | Data acquisition, Getting Started, LC, SCIEX information, SCIEX OS software, TechnologyDifferent LC options are supported in SCIEX OS software and Analyst software. Those that communicate through ethernet differ in their default IP addresses. In this community post, we will detail the LAN setup, configuring the IP address and subnet mask for LC...
Getting access to demo data and other files for learning the OneOmics suite by Alexandra Antonoplis | Getting Started, Life Science Research, Metabolomics, Multi-Omics, OneOmics, Proteomics, QTOF, SCIEX information, ZenoTOF 7600 systemIn order to help you get proficient in using the OneOmics suite workflows, we have provided some demo datasets along with numerous other valuable files and supporting information to help you get started. Once you get access to your SCIEX Cloud account and can view...
What is SWATH acquisition and what are the critical acquisition attributes? by Christie Hunter | Data acquisition, Food / Beverage, Food and Beverage, Forensic, Fundamentals, Life Science Research, Metabolomics, OneOmics, Pharma, Proteomics, QTOF, SCIEX information, Toxicology, ZenoTOF 7600 systemIn data-independent acquisition strategies like SWATH acquisition, an expanded mass isolation window is stepped across a mass range covering the mass-to-charge (m/z) distribution of peptides and a full scan MS/MS spectrum is collected at each step. Post-acquisition,...
What is the Zeno threshold and what does it do? by Robert Di Lorenzo | Bioanalysis/PK, Data acquisition, Lipidomics, Metabolomics, Multi-Omics, Proteomics, SCIEX information, SCIEX OS software, Technology, Toxicology, ZenoTOF 7600 systemWith the introduction of the Zeno trap on the ZenoTOF 7600 system, sensitivity improvements on the order of 4 to 25x can be seen for MS/MS analysis, because of the optimization of duty cycle.1 When concentrations are low and peak intensities are limited, this bump in...
Decision Rules in SCIEX OS software by April Quinn-Paquet | Data acquisition, How-to videos, SCIEX OS software, TechnologyLearn how Decision Rules in SCIEX OS software can be used during acquisition to take corrective actions on the sample queue. This will help you save time and reduce sample losses during acquisition. RUO-MKT-11-13239-A
What’s in your citrus oil? by Craig Butt | Blogs, Food / BeverageCraig Butt explains a non-targeted omics approach to characterizing and profiling compounds in citrus oil Read time: 4 minutes There is increasing interest among consumers in the benefits of natural products containing citrus beyond the traditionally known benefits of...
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready by Jianru Stahl-Zeng | Blogs, ClinicalSensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
Importing acquisition methods from Analyst software to SCIEX OS software by April Quinn-Paquet | Data acquisition, How-to videos, Methods / workflows, SCIEX OS software, TechnologyThe SCIEX Triple Quad 7500 system is the first nominal mass instrument to be released completely on SCIEX OS software. Moving to a new software solution can be time consuming with the need to transfer numerous methods to the new platform. SCIEX OS software helps...
A rising star in food allergen research: proteomics of shellfish allergen by SCIEX Community | Blogs, Food / Beverage, Life Science Research, ProteomicsIt’s important to know what you’re eating, especially if you suffer from a food allergy. About 220 million people worldwide live with a food allergy.1 These numbers, along with the complexity and severity of conditions, continue to rise. In America, there are about 32 million food allergy sufferers—5.6 million of those are children under the age of 18.2.2 That’s 1 out of every 13 children, or about 2 in every classroom. From a financial perspective, the cost of food allergy childcare for US families is up to $25 billion
Using Mass Spectrometry for Down Syndrome Metabolomic Research by SCIEX Community | Blogs, Life Science Research, MetabolomicsLast week we launched a really interesting research project with Jeff Miller, Senior SCIEX Scientist, using a SCIEX QTRAP® 6500 mass spectrometer. Our plan was to test whether acetaminophen is metabolized differently in people with Down Syndrome (our younger brother William has Down Syndrome).