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How does multi-precursor searching work in ProteinPilot software 5.0?
In highly complex proteomics data, some percentage of MS/MS spectra is chimeric due to the transmission of more than 1 precursor through the MS isolation step, even with a 1 Da window like the one used on TripleTOF systems. The ProteinPilot software 5.0 release includes a new multi-precursor search capability that enables the identification of […]
- Data processing
- Life Science Research
- ProteinPilot
- Proteomics
- QTOF
- SCIEX information
- ZenoTOF 7600 system
August 5, 2021
Isoform-specific quantification in ProteinPilot software
During a ProteinPilot software search, the Pro Group algorithm assembles all the peptides into their appropriate proteins. Before the protein ratios are computed, the peptides are automatically annotated according to specific properties that make them more or less useful for quantification. A key property that is directly determined during protein grouping is whether the peptides […]
Understanding the Paragon algorithm for database searching in ProteinPilot software
This short video provides an overview of the Paragon algorithm, a novel search engine that enables a researcher to search and identify a broad range of proteins and post-translational modifications in a single search, without increasing false positives and not drastically impacting search time.  Using the unique tag-based search and the sequence temperature value strategy with feature probabilities […]
How does mass recalibration work in ProteinPilot software?
To perform automatic mass recalibration, ProteinPilot software first conducts a rapid search using mass tolerances that are wider than expected for the instrument in use. The mass tolerance used in this initial search is defined in the MSTOLERANCE VALUE and MSMSTOLERANCE VALUE settings in the parameter translation file (Figure 1). To see what these values […]
Parameter Translation Layer in ProteinPilot software
ProteinPilot software is the only database search engine that provides a user interface which is “easy on top, powerful underneath!” Â Learn how the parameter translation layer turns knowledge of chemistry and mass spectrometry into their complex informatic implications. It is this translation layer that allows the user interface of ProteinPilot software to be simplified and easy for all to use.
Pro Group algorithm and how it works in ProteinPilot software
Watch this video as Christie Hunter explains the Pro Group algorithm and how it works in ProteinPilot software. Let us know if you have any questions by commenting below. RUO-MKT-11-1780-A
The risky business of aflatoxins in milk
If you’re in the dairy or food testing business, you know the threat aflatoxins pose. Aflatoxins are a type of mycotoxin produced by Aspergillus parasiticus, aspergillus flavus , and rarely aspergillus nomius.1 These are likely the most extensively researched group of mycotoxins because of their adverse health effects.2 What’s more, they are widely found in a variety of crops, namely maize, tree nuts, and spices. Believed to be primarily caused by rising temperatures and humidity, these naturally occurring fungi grow on crops in the field, or during storage of feed and raw materials, where they can potentially produce toxins that enter the food chain.
Tags: animal, chain, challenge, extraction, food, food chain, food ingredients, food safety, fungi, information, knowledge, mass, milk, money, power, produce, product, quality control, research, residue / contaminate testing, safety, science, testing, water
August 3, 2021
The ugly truth about beauty products: PFAS in cosmetics
Scientists find signs of potentially dangerous “forever chemicals” in more than 100 popular makeup products
If you have ever wondered what gives long-lasting cosmetics their staying power, you may now have your answer. Scientists have found highly persistent, potentially harmful “forever chemicals”—known as per- and polyfluoroalkyl substances (PFAS)—in half of the cosmetic samples they tested in a new study published in June 2021.1
Tags: drinking water, water & soil
An interview from the Science Explorer about the Echo® MS system
The Science Explorer interviews Neil Walsh from SCIEX to discuss the significant application areas of the Echo® MS System and what makes this system so attractive to biopharmaceutical laboratories.
Tags: AEMS, Biopharma, drug discovery, Echo MS, high-throughput screening, HT-ADME, Pharma
July 19, 2021
The metabolome: the way to personalized healthcare?
Read time: 15 minutes The completion of the human genome project in 2003 opened the door to unprecedented insight into the human body through its DNA code. We now know that our genome encodes our proteins, that our proteins are the molecular machinery of certain functions that take place in our cells and that the […]
Tags: clinical diagnostics, drug discovery, healthcare, metabolite, metabolome, Metabolomics, personalized medicine, phenotype, precision medicine, small molecules
July 15, 2021
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