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Page 13 of 61
Overcoming N-nitrosamine analysis challenges with mass spectrometry and chromatography solutions
N-nitrosamine analysis has raised significant concerns in the pharmaceutical industry since 2018, when these potential carcinogens were found in several angiotensin II receptor blockers (sartans). Subsequent discoveries in ranitidine and some slow-release metformin medications prompted widespread product recalls. The industry has implemented stricter manufacturing requirements and intensified efforts to evaluate and control N-nitrosamine contamination. To meet stringent regulatory requirements, it is essential to develop effective chromatography and mass spectrometry (MS) methods for N-nitrosamine analysis. This blog addresses the challenges associated with detecting N-nitrosodimethylamine (NDMA) in metformin drug products.
Tags: contaminations issues, nitrosation, SCIEX QTRAP 6500+ LC-MS/MS System
September 6, 2023
Understanding technical debt: the hidden cost of ignoring problems
In today’s rapidly evolving technological landscape, businesses heavily rely on software and IT systems to drive their operations. However, the pursuit of efficiency and speed often leads to the accumulation of what is known as technical debt. Technical debt refers to the implied cost incurred when businesses choose quick but limited solutions over better approaches that may take more time to implement. This blog post will delve into the concept of technical debt, its implications for businesses and how to avoid falling victim to its detrimental effects.
Tags: Analyst Software, lab optimization, money, SCIEX OS Software, software, technical debt
August 31, 2023
Omics in the rapidly developing field of alternative proteins: innovation and safety
On June 12, 2023, during a webinar hosted by New Food, Lin Qingsong—Principal Research Fellow and Director of the Protein and Proteomics Centre at the National University of Singapore—discussed the latest considerations related to risk assessment of alternative proteins.
August 30, 2023
Want to accelerate your drug discovery workflow?
Bringing a new drug to market is a costly and complex process. With potentially hundreds of thousands of new compounds to screen during drug discovery, sample throughput is a common bottleneck for pharmaceutical companies. So how do you overcome this barrier?
Tags: ADME, Echo MS, High-Throughput Drug Discovery, Pharma
August 4, 2023
Reporting only unknown samples containing a specific sample ID prefix (in this case Sample ID prefix = PHT)
I am using Multiquant software and I am trying to create a report to pull data on specific sample from a large run.
Tags: member_question, Multiquant, report
July 24, 2023
Selecting the right system for metabolite identification
So, you need a new liquid chromatography-mass spectrometry (LC-MS) system for your metabolite identification (metID) studies, and you are not sure which option is right for you. This blog provides an overview of the metID solutions offered by SCIEX, so you can make the best decision for your organization.
Tags: confident identification, ExionLC 2.0+ systems, Met ID, Metabolite Identification, MS, X500R
July 14, 2023
Baseline Dip using PA800 Plus SDS-MW Application
We’ve noticed that with some gel buffer lots, we see a dip in the baseline at 280 nm when analyzing proteins per the SDS-MW protocol. Has anyone experienced this before? We don’t always see it and are wondering what causes the dip.
Tags: member_question
July 13, 2023
N-Methyl Pyrollidone
I am in the process of analyzing nitrosamines using QTRAP. One of the difficulties in my sample preparation would be using NMP as solvent to dissolve the material. Is it safe to inject approximately 10ul of NMP is QTRAP??
Tags: member_question
June 22, 2023
Please provide at least 3 decimal places for expected retention time for scheduled MRM at EchoMS
Expected retention time for scheduled MRM at EchoMS must have at least 3 decimal places, because the minute display with two decimal places is insufficient to show the difference in seconds. Thank you.
Tags: decimal, display, member_question
Page 13 of 61