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Lipid nanoparticles (LNPs) are widely used vehicles for messenger RNA (mRNA)-based therapeutics and vaccines. However, ionizable lipids used in LNPs can be susceptible to N-oxide impurities that can cause functional loss of the mRNA cargo.

Tags: adam crowe, adducts, lipid nanoparticle, lnp, pni

February 20, 2024

Metabolite identification and peace of mind

Managing metabolite identification (Met ID) studies is challenging, so what is at the top of your priority list as you plan the year ahead? Ensuring you have the data needed to manage product safety, meeting deadlines, staff recruitment and training, maintaining compliance, capital expenses, or something else?

Tags: business, computer, dissociate, good, help, identification, information, job, manage, management, meet, Metabolite Identification, science, service, software, study, support, system, time, use, work

February 13, 2024

Limit on the number of elements in untargeted workflow–”Formula Finder Section”

How can I limit the minimum number of elements for formula searching in sciex os non-target data processing procedure? I need a range and not just the maximum number of elements.

Tags: Formula Finder, member_question

November 16, 2023

Beyond mRNA: how advances in analytical techniques are enabling a revolution in the RNA drug landscape

Currently, there are 3 main types of in vitro transcribed (IVT) RNA drugs. Two of these—conventional messenger RNA (mRNA) and base-modified mRNA (bmRNA), which incorporates chemically modified nucleotides—are non-replicating. The third type is self-replicating RNA (srRNA), which is based on an engineered viral genome but devoid of viral structural protein genes. Its self-replicating ability makes srRNA a promising tool for new therapeutic drugs.

Tags: replicate webinar, rna, sarna

November 7, 2023

SCIEX OS software analytics – Change default folder for reports

When using Sciex OS for data processing, the reports created in the analytics module are by default saved into C:\ProgramData\SCIEX\Analytics\Reporter\Reports. How can this default folder be changed?

Tags: analytics, member_question, report, sciex os

October 19, 2023

Changing the game of drug development with the Intabio ZT system

What better to learn how a new technology like icIEF-UV/MS is advancing drug development than hearing from the labs that are using it?

Tags: biopharmaceutical characterization, biopharmaceutical development, charge variant analysis, Drug development, icief, imaged capillary isoelectric, Intabio, Janssen, process development

October 4, 2023

Data acquisition on the Echo® MS system: post-acquisition file splitting

The Echo® MS system is an ultra-high-throughput system that analyzes samples at a speed of up to 1 sample per second. To achieve fast acquisition speeds, MS data is collected for an entire batch—or the entire well plate—into a single experiment in a file. Post-acquisition, SCIEX OS software parses the data from that single experiment […]