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Maximize NPS analysis with accurate mass spectrometry
LC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many advantages, including the ability to reliably detect new drugs and their metabolites from a variety of biological matrices.
Tags: accurate, acquisition, analysis, data, Forensics, fragment, identification, knowledge, mass, NPS, precursor, research, sample, science, spectrum, time
March 11, 2024
Unlock the benefits of nominal mass spectrometry for NPS analysis
The development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and the quality of the results. They also need robust and sensitive instrumentation that can detect drugs at trace levels with high specificity, especially when it comes to novel psychoactive substances (NPS), which can be difficult to monitor and control.
Tags: analysis, check, function, ion, job, mass, mode, model, MS/MS scanning vs traditional QqQ and LIT instruments, multiple reaction monitoring (MRM), perfect, QTRAP, research, scan, science, specific, system, triple
Change Filename after acquisition?
When using SciexOS software analytics application:
Tags: analysis, batch, book, change, collection, document, duplicate, file, forget, index, individual, information, instance, machine, member_question, model, possible, sample, text, triple, use
March 7, 2024
Relative migration time
How do I set up my processing method to calculate the RRT of the main peak to 10kD in karat 32 software?
Tags: calculate, form, member_question, method, peak, permit, position, process, processing, progress, science, set, setup, software, striking, training, value
What mobile phases can be used with the PFAS Free LC Kit?
I have a Exion LC AD fitted with the Exion LC AC PFAS kit – I’m looking into running another application on the instrument alongside PFAS analyses that uses 0.2% Formic Acid in H2O as one of the mobile phases. I can’t find any literature on whether the components in the kit are compatible with a formic acid solution as the mobile phase. Has anyone had experience running with this MP on this kit?
Tags: acid, ad, alongside, application, computer, ExionLC, good, instrument, kit, knowledge, look, machine, member_question, mobile, Mobile Phase, PFAS, PFAS Free, phase, question, repair, running, technology, time, tool, Tubing, work
Sciex OS – report automatically opens
Hi,
Tags: automatically, behaviour, button, change, clothes, computer, create, cut, excel, file, form, hi, member_question, model, open, record, report, right, sciex os, way
Injection Counter
Hi,
Tags: active, analyst, change, column, computer, counter, different, form, hi, Injection Counter, machine, mean, member_question, number, party, position, setup, species, system, time, use, valve
Error when saving result table Analyst 1.7.3
When saving data or result table to a network share
Tags: able, article, available, book, car, computer, desk, file, food, human, idea, item, member_question, object, permission, read, saving, space, stuff, user, wright
High mass tuning calibration for ZenoTOF 7600
Hi,
Tags: custom, direction, face, group, job, lead, like, link, look, member_question, opinion, order, range, sensitivity, similar, tune, use, used, way, word, work
Jon MacGregor
I have a turbo v ion source that shows a glowing blue/purple light at the tip of the Heated Nebulizer corona discharge needle, even when it is not in use and turned out of ion path as it should be when using TIS probe. It only happens in negative mode. It is not arcing to the cutain plate, just a slight noticeable glow at the tip of the corona needle when observed through the front window. My FSE has rebuilt the HN probe and components and also installed a new TIS probe. Still glows when in negative mode. Note also having poor sensitivity in negative mode as well and jagged peak shapes during infusion. Any ideas? Are the symptoms related?
Tags: 03/05/2024, corona, fact, feature, form, glow, ion, jagged, light, line, machine, member_question, mode, needle, negative, probe, product, run, shape, tip, use, work
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