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Acoustic Ejection Mass Spectrometry at ASMS 2023
For all those interested in learning about all the cool applications possible with AEMS and the Echo MS system, here is a list of presentations at ASMS 2023. Monday: MOH 3:50pm – Intact protein analysis MP 294 – Metabolite identification MP 312 Compound QC Tuesday TOB 9:30am – Peptide analysis 3:30pm – Echo MS system […]
Tags: analysis, assay, day, echo, engineering, enzyme, forward, happy, hour, interested, look, monday, morning, night, record, system, thursday, wednesday, week, year
June 4, 2023
Processing ZenoTOF data using the Human Pan-Human library from Swath Atlas (phl004_canonical_s32_osw.csv) and DIANN
Hello,
Tags: library, member_question, swath
May 17, 2023
Standard peaks are noisy
I am Using Sciex Qtrap 4500 for quantification of nitrosamines (NDMA&NDBA). I am facing issue with higher baseline intensity. When developed the method in APCI the basline was at about 5e4. but now even after cleaning the source (i.e. Changed capillary to new, Curtain plate & Corona needle cleaning, given blank injection overnight ), my base line decreased from 1e6 to 4 e5, but settled at 4 e5 from past 24 hours. can you suggest me how decrease my baseline intensity further to below 1e5. My standard peaks are like noise now.
Tags: APCI, High Baseline intensity, member_question, Nitrosamines
Loss the contact closure signal
our 7600 couple with nanoLC Ultimate 3000 via contact closure. it has run without any loss connection during the batch. Just yesterday, the last injection keep equilibrating system until the LC finished the gradient run. We closed the software and power off LC and MS then started again but it did not help. The Dionex engineer also checked their LC and triggerring cable found both are ok.
Tags: cable, checked, close, computer, connection, contact closure, couple, current, direction, engineer, issue, item, link, machine, member_question, open, regard, run, similar, software, solve, work
Easing the demands of a compliant pharmaceutical laboratory
At SCIEX, we are proud to provide analytical systems to the pharmaceutical industry. We work hard to understand the demands of analytical work and the processes required to develop and manufacture drugs.
Tags: Compliance, Pharma, Regulatory
May 4, 2023
General question on SCIEX 7500
Good morning.
Tags: instrument, member_question, temperature
May 1, 2023
Analytical techniques for novel psychoactive substances (NPS) screening
The increased prevalence of novel psychoactive substances (NPS) in the recreational drug market has been a major contributor to the ongoing opioid crisis. NPS are newly emerging compounds designed to mimic existing recreational drugs and have become potent alternatives to controlled opioids. They are also frequently used as adulterants or cutting agents for commonly abused drugs. Continuous abuse of these substances can result in severe intoxication and, in some cases, fatal overdose.
Tags: novel psychoactive substances, NPS, NPS analytical techniques
April 21, 2023
Library database file types imported into LibraryViewâ„¢
As is stated in official guidance, many different types of compound and library databases can be imported into LibraryViewâ„¢ software, such as Excel file (*.xls) and Third Party Library Package (*.tplp). Can somebody tell me what’s the format like “tplp”, which is so rare that there is nothing about it online. And I don’t know […]
Tags: excel, file, format, library, member_question, question_resolved
April 18, 2023
Optimized rolling collision energy curves for IDA and SWATH DIA for peptides
During data dependent acquisition (DDA or IDA) or SWATH acquisition, the collision energy can be automatically adjusted according to the mass/charge and charge of the peptide. This dependency has been well characterized on our QTOF systems. By selecting rolling collision energy (Analyst software) or dynamic collision energy (SCIEX OS software) this function is invoked during […]
Tags: acquisition, analyst, change, collision, computer, control, developed, dynamic, energy, law, machine, money, object, option, power, select, setup, software, system, use
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