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Page 15 of 61
What has the Echo® MS system done for the pharma industry? (And don’t just take our word for it!)
SCIEX was very proud to have an illustration of the Acoustic Ejection Mass Spectrometry (AEMS) technology that powers the Echo® MS system on the front cover of the Journal of the American Society for Mass Spectrometry in January 2023. The associated article—Ultrahigh-Throughput Intact Protein Analysis with Acoustic Ejection Mass Spectrometry—was co-authored by scientists from SCIEX and Merck.
Tags: acoustic, acoustic ejection, aems technology, article, assay, computer, discovery, drug, Drug development, echo, Echo MS, eject, government, HT-ADME screening, information, machine, mass, model, Pharma, research, science, screening, system, time, work
March 27, 2023
Protein Pilot Cysteine Modification
Hello,
Tags: addition, change, member_question, modification, residue
March 24, 2023
5 Reasons to choose the Echo® MS system for high-throughput drug discovery
Have you thought about introducing new technology into your high-throughput drug discovery lab? Here are 5 reasons the Echo® MS system could make a difference for you.
Tags: ADME, Echo MS, High-Throughput Drug Discovery, Pharma
March 22, 2023
The age of novel psychoactive substances
Novel psychoactive substances (NPS) are compounds designed to mimic existing recreational drugs. The emergence of NPS has changed the landscape of the synthetic drug market. While previously the market had a limited number of compounds belonging to a few chemical groups, with NPS it now has hundreds of compounds. The European Monitoring Center for Drugs and Drug Addiction is currently monitoring 730 substances, with more being identified each year.
March 9, 2023
What have we learned from the nitrosamine crisis?
The pharmaceutical industry is facing an ongoing issue with genotoxic impurities (GTIs). Over the past year, we have witnessed genotoxic impurities affect several drugs, including those used to treat elevated blood pressure, heartburn and acid reflux. Angiotensin II receptor blockers (including valsartan, losartan and irbesartan), along with ranitidine and nizatidine, were recalled to investigate several […]
Tags: APIs, Drug manufacturing, Genotoxic Impurities, Nitrosamines, Pharma, quantification
January 30, 2023
Top 7 Echo® MS system customer questions—answered
You asked, we answered! With analysis speeds of at least 1 sample per second, the Echo® MS system has created a buzz in the industry. This is up to 50x faster than conventional LC-MS/MS. This revolutionary tool for drug discovery and development has led to many questions from scientists and researchers around the world. […]
Tags: AEMS, Biopharma, drug discovery, Echo MS, high-throughput screening, HT-ADME, Pharma
January 29, 2023
Take out the PFAS in our takeout
Per- and polyfluoroalkyl substances (PFAS) were first detected in wildlife1 and oceanic waters2 in the early 2000s. Recently, however, these chemicals have been found in school uniforms,3 cosmetics4 and food contact materials,5 shifting what was initially considered an environmental issue to a public health crisis. As concerns have grown about the toxicological impact of long-term PFAS exposure on human health, questions about food-borne exposure have surged, especially since these chemicals are used in disposable food packaging materials, non-stick cookware and even in food processing machinery.
Tags: PFAS, PFAS Food, PFAS Food packaging
January 20, 2023
Handle with care: Ensuring LNP lipid quality for better genetic medicines
Lipid nanoparticles (LNPs) are widely used vehicles for oligonucleotide-based therapeutics and vaccines. However, LNPs can be susceptible to N-oxide-based impurities that can cause messenger RNA (mRNA) to lose function.
Tags: lipid nanoparticle, lipid quality, lnp
December 19, 2022
The secrets of recycling: PFAS and 6PPD
Recycling and reusing items is generally accepted as the “right” thing to do. But what if there were unintended, negative consequences to recycling? For example, old car tires are often ground down and reused for synthetic turf, with roughly 40,000 tires used per field.1 However, car tires contain the chemical 6PPD,5 which is converted by ozone to a quinone compound 6PPD-quinone (6PPD-Q) and enters river systems where it is toxic to coho salmon. In addition, some studies have detected per- and polyfluorinated alkyl substances (PFAS)— the” forever chemicals”—in artificial turf,1,4 which means it may be a source of PFAS found in nearby water supplies and potentially in drinking water.
Tags: 6PPD, 6PPD-quinone, Environmental contaminants, PFAS, PFAS analysis, PFAS testing
December 16, 2022
Methods for OPI electrode cleaning for Echo® MS system electrodes
Depending on the samples you are running on the system, it is possible for the Open Port Interface (OPI) electrode to become dirty or occluded over time. Below are two different cleaning strategies that can help you maintain your Echo® MS system and keep your OPI electrodes running well. Quick cleaning protocol This protocol is […]
Tags: air, cleaning, design, electrode, flow, food, machine, minimum, model, nut, protocol, run, running, solvent, species, system, time, wash, water, work
November 23, 2022
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