According to the American Clinical Laboratory Association, more than 7 billion clinical lab tests are performed in the U.S. every year. While mass spectrometry represents only a fraction of the clinical applications, there are a growing number of tests where mass...
Tags
Loss the contact closure signal
our 7600 couple with nanoLC Ultimate 3000 via contact closure. it has run without any loss connection during the batch. Just yesterday, the last injection keep equilibrating system until the LC finished the gradient run. We closed the software and power off LC and MS then started again but it did not help. The Dionex engineer also checked their LC and triggerring cable found both are ok.
Echo MS system maintenance operations
The Echo® MS system is a robust platform, and like any other platform, requires some routine maintenance on a regular basis. Here are 3 maintenance steps that can help you ensure consistent, reliable performance: Immediately before use or after switching carrier...
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
The honey sting
As a consumer it’s hard for me not to feel inundated with claims that our food is “all-natural” or “chemical-free” or that we should buy certain “superfoods” for their health benefits. We read labels and trust that the product we are buying is what we are truly...
Innovation that’s blasting through limitations in explosive detection
Mass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
A new generation of therapeutic modalities
There are over 7,000 genetic diseases that could potentially be cured using gene therapy. Rare metabolic diseases, autoimmune disorders, cardiovascular disease and cancers are some of the top disease classes that can be addressed with gene therapies. With over 1,000...
Enhancing Biologics with CESI-MS Characterization
Comprehensive characterization of a biologic requires analysis at both the intact and digest levels, but these analyses can be complex and cumbersome. For example, with conventional liquid chromatography separations, researchers are often left with limited information...
Full, partial and empty capsid ratios for AAV analysis: What’s the big deal?
For many of you working to develop gene therapy drugs, you know that the time to market the drug is critical. Because gene therapeutics cure diseases by targeting specific genes, it is a constant race to see who develops the drug first. Unlike other classes of drugs where multiple medications can be used to treat a disease, whoever is first to develop a gene therapy drug wins.
Accurate mass LC-MS/MS for PFAS analysis without needing a blockbuster budget
If you’ve been following our recent blogs, you’ve probably seen quite a bit on how per- and polyfluoroalkyl substances (PFAS) are shaking up both the food and environmental industry. Even if you’ve not been following our blogs, you’ve probably seen a lot of media...
A rising star in food allergen research: proteomics of shellfish allergen
It’s important to know what you’re eating, especially if you suffer from a food allergy.
About 220 million people worldwide live with a food allergy.1 These numbers, along with the complexity and severity of conditions, continue to rise. In America, there are about 32 million food allergy sufferers—5.6 million of those are children under the age of 18.2.2 That’s 1 out of every 13 children, or about 2 in every classroom. From a financial perspective, the cost of food allergy childcare for US families is up to $25 billion
QTOF Technology for Targeted and Unknown Forensic Drugs Screening Workflows
In this study, the Wisconsin State Laboratory of Hygiene (WSLH) outlines the comparison of their existing technology and how SCIEX LC-MS/MS systems can assist them in their forensic research. The WSLH routinely analyze for 300 forensic drug compounds in over 18,000 samples per year.
Expert Advice to Help You with Routine Food Testing in the Lab
Between 3-6 November 2015, the Recent Advances in Food Analysis (RAFA) 2015 Symposium took place in Prague, Czech Republic.
Contaminants and Novel Approaches in Food Analysis
During RAFA 2015, New Food Magazine hosted a roundtable (sponsored by SCIEX) to bring together experts with routine food testing backgrounds to discuss the latest industry trends, challenges, recent technological advances, and expectations of future laboratories.
Polar Pesticide Analysis by CESI-MS for Routine Food Testing – A Poster Talk
Method development for routine food testing presents many challenges – whether you are looking to increase the speed of your screening or simplify your method there can be different solutions suited to the task at hand. During RAFA 2015 in Prague, Steve Lock, Market Development Manager for SCIEX Separations in EMEA outlines how CESI-MS may be best suited for polar pesticide analysis.
Using Mass Spectrometry to Detect Trace Ingredients in Food – a Poster Talk
In today’s poster talk Jens Dahlmann, Senior Applications Specialist at SCIEX discusses how mass spectrometry might be best suited to the identification of trace ingredients in foods.
How You Can Detect Pesticide 1080 In Milk & Infant Formula – A Poster Talk
In this poster talk André Schreiber, Applications and Product Manager for Food and Environmental Markets at SCIEX guides you through a new method developed in conjunction with Association of Analytical Communities (AOAC). The method is designed to better detect a harmful substance that the infant formula and milk industry are under threat from – Sodium Fluoroacetate, otherwise known as Compound 1080 or Monofluoroacetate.
Drug Metabolism and Bioanalysis Journal Articles Focus on Drug Metabolism and so Much More
Check-out the top articles that focus on innovations in drug metabolism as well as small molecule quantitation and biologics bioanalysis. Exciting advancements! We can’t wait to see all that will come in 2016! Quantitative analysis of maytansinoid (DM1) in human serum...
Reasons why LC-MS/MS is my method of choice for meat speciation and authenticity testing
The meat trade hasn’t had a good reputation since the horsemeat scandal that burst into headlines in 2013. The scandal has left such a mark that meat speciation, adulteration and authenticity are still high-profile topics today. Think about it from a...
Purchasing Mass Spec Technology for Your Forensic Lab
What does every scientist think about in the lab? Validation. This is the feeling I encountered while reading a recent scientific report on nature.com. What struck me was not only the study itself which discounted cannabinoid incorporation into hair as a method for...
A Reliable Method for the Identification, Quantitation, and Confirmation of Pesticides
When carrying out routine pesticide identification tests in your lab how simple is the process of identification, quantitation, and final confirmation from sample to sample? A reliable method designed to generate multiple data sets and confirm sample data in parallel with your test can save an awful lot of time and effort which is especially helpful as the demand for routine testing increases. In this poster talk, Detlev Schleuder, Support Manager for Food & Environmental Markets, explains how the new QTRAP® 6500+ system can optimize your laboratory’s output with this simple method.
The Gluten Free Cookie Label Test
I am a label reader. I like to eat healthily and know what the long, confusing ingredients on the side of a package mean. Therefore, in the spirit of the holiday season, I dedicate this blog to all the gluten intolerant folks out there whose only wish is to eat a yummy cookie while also being absolutely positively sure it is gluten free.
Testing Liquor for Authenticity Using LC-MS/MS Technology
The Proof is in Your Holiday Drink If you think bootlegging was limited to the age of Prohibition then you have never tested liquor for authenticity using mass spectrometry. Maybe it is a scientist thing, but we simply cannot help but bring up the subject as people...
Five Tips for Safe Handling Holiday Decorations
Bring out the boxes of decorations this holiday season and while you are at it, keep in mind you could be facing dangerous exposure to chemicals too. From trees to garland, candles and toys, here are some tips to keep in mind for safe handling. Trees Fake trees are...
Gain New Insights Into Human Spermatogenesis with this “Click & Easy” OneOmics Workflow
A recent webcast by Charles Pineau, Director of Protim, IRSET, Rennes, France, demonstrates how you can use the OneOmics™ Platform as a "Click & Easy" workflow for integrating next-generation proteomics (NGP) data with next-generation sequencing (NGS) data. Dr....
Thanksgiving Menu: A Detectable Feast!
On Thursday 26th November 2015, millions of households across the United States will sit down to a hearty traditional Thanksgiving meal. The Thanksgiving holiday is when people celebrate the blessings of the year, in particular the harvest.
Are there Antibiotics in your Thanksgiving Turkey?
Truth – the first turkey I ever cooked was still frozen when it hit our plates. I couldn’t figure out why that thing was taking so long to roast. Then it hit me. I forgot to defrost the bird. If I recall correctly, even the giblets were still in it. It was ten p.m. when I broke the news to my guests that the turkey was not happening. A pizza was ordered, and everyone breathed a sigh of relief that they would not be suffering from a bout of food poisoning.
Celebrate with a Pesticide Free Thanksgiving!
Before you start wondering if you should buy organic ingredients this Thanksgiving, it is good to know regulating bodies set and monitor allowable pesticide limits within our food supply. Pesticides that help control pests, disease, and deter unwanted animals from eating supplies found in fields, mills, and facilities. How and when this testing takes place in the United States is overseen by the Environmental Protection Agency (EPA) according to five primary regulating statutes.
Keeping Up with Synthetic Cannabinoids Using Mass Spec
Facts about Synthetic Cannabinoids and why you need to pay attention to evolving science
Mass Spectrometry Helps Researchers Solve a Mystery about Type 2 Diabetes Drug
This is an article from November 21, 2013. We thought it was an interesting story to share with you on this World Diabetes Day.
For the research conducted by the Australian and Canadian researchers, the analysis at the molecular level was optimized on SCIEX instrumentation, including the SCIEX TripleTOF® 5600 and the SCIEX QTRAP® 5500 system
Top Three Ways SCIEX has fun with Halloween Candy
Halloween is the time for lots of trick or treats ranging from chocolate bars to lollipops and oh so good candy corn. However, come October 31, it is time to mind sneaky ingredients that have the best disguise of all. From pork extracts, artificial sweeteners, to stuff that is hard to pronounce, SCIEX digs up some of our recent Food and Beverage studies for some ghoulishly good fun.