Save Effort. Save Time. Consolidate Your BioTherapeutic Quality, Safety, and Efficacy Assessments with One Direct LC-MS MAM Assay. by SCIEX Community | 0 CommentsIn a previous blog, we learned how you could Simplify Your Life with a Streamlined Workflow for Multiple Attribute Methodology (MAM). Based on the well-known technique of peptide mapping, a Liquid Chromatography-Mass Spectrometry-based MAM workflow (LC-MS MAM) enables...
Metabolism and Biotransformation – What Are You Missing? by SCIEX Community | 0 CommentsAre you looking to improve your MetID studies? Want to achieve the productivity and throughput you need to keep your projects moving and have complete confidence that you’re not missing any low level or parent-like metabolites in your sample? In this blog, we’re...
Biologics Characterization: Intact and Subunit Mass Analysis by SCIEX Community | 0 CommentsWhen All You Need Is Range – Mass Range, Dynamic Range, and the Complete Range Launching the best possible product in the shortest time possible is key for pharmaceutical companies like you. As you know, nearly every process throughout the biologics development cycle...
Now You Can Overcome Your Food and Environmental Testing Obstacles by SCIEX Community | 0 CommentsHow do you safeguard human health and protect your reputation through meeting stringent global food and environmental safety standards? When it comes to testing food and environmental samples, the quality of your testing data is vital to your business. You need fast...
Celebrating customer experience: Insights from SCIEX leaders by Philip Taylor | Biopharma, Blogs, Clinical, Environmental / Industrial, Food / Beverage, Forensic, Life Science Research, Pharma, TechnologyIntroduction Customer Experience Day (CX Day) is a special occasion for SCIEX, celebrated every first Tuesday in October. It’s a day dedicated to recognizing the incredible value of our customers and the relentless dedication of our associates who strive to make...
LC-MS system replacement: Are you ready? by Kirsten Craven | Blogs, Pharma, QTRAP / Triple QuadMeeting deadlines in a bioanalysis laboratory can be a big challenge. Older, less sensitive and less reliable LC-MS systems make it even more difficult. Even the disruption caused by the installation and validation can be disconcerting and delay decisions. Does this sound familiar?
Questions and answers to help improve your mycotoxin analysis by Michael Zellmann | Blogs, Food / Beverage, Food and BeverageDuring a recent webinar I shared method details for mycotoxin analysis on the SCIEX 7500 system. In this blog i will share the Q&A for the submitted questions that we did not have chance to answer during the live webinar.
Optimized rolling collision energy curves for IDA and SWATH DIA for peptides by Christie Hunter | Data acquisition, Life Science Research, Proteomics, QTOF, SCIEX information, ZenoTOF 7600 systemDuring data dependent acquisition (DDA or IDA) or SWATH acquisition, the collision energy can be automatically adjusted according to the mass/charge and charge of the peptide. This dependency has been well characterized on our QTOF systems. By selecting rolling...
Back to the new basics: Part 1 | Making the leap from GC-MS to LC-MS by Alex Liu | Biopharma, Blogs, Clinical, Environmental / Industrial, Food / Beverage, Forensic, Life Science Research, PharmaProducing accurate results quickly in a demanding environment is no easy feat for analytical scientists. What’s more, many of us are constantly questioning ourselves—I certainly am—about whether we are employing the best technique for the analysis at hand. It’s an overwhelming thought, considering the wide range of tools that are available to choose from, each of which offers varying levels of capacity, sensitivity, selectivity, specificity and cost. How do you meet the unique needs of your organization without breaking the bank? I get it, and I’m not here to convince you it’s easy. My aim is to guide you through the process to help you make the right decision for you.
MRM method transfer from a SCIEX Triple Quad or QTRAP 6500+ system to the SCIEX 7500 system by Christie Hunter | Bioanalysis/PK, Data processing, Methods / workflows, Pharma, QTRAP / Triple Quad, SCIEX information, SCIEX OS softwareGeneral recommendations when beginning method development Objective: The purpose of this document is to provide a quick reference for transferring MRM-based quantification methods from a SCIEX Triple Quad or QTRAP 6500+ system to a SCIEX 7500 system. While the best...
Adapting a SCIEX high flow source for microflow LC by Christie Hunter | Data acquisition, Development, Ion sources, LC, Life Science Research, Metabolomics, Pharma, Proteomics, SCIEX informationTo set up a SCIEX high flow source for microflow LC (Turbo V ion source, DuoSpray source or IonDrive Turbo V ion source), first you must replace the wider bore electrodes with more narrow bore hybrid electrodes. Note with the OptiFlow Turbo V ion sources, there are...
Identifying the unknown PFAS profile in firefighting foams/AFFF by Craig Butt | Blogs, Environmental / IndustrialAccording to a recent study from Harvard University, the US EPA, and NIEHS, traditional targeted analysis techniques poorly characterize the PFAS composition of contemporary PFAS-based firefighting foams, know as aqueous film-forming foams (AFFF). Using the EPA 533 PFAS drinking water method for the analyte list, the researchers found that targeted mass spectrometry methods accounted for <1% of organic fluorine content. This is important because it demonstrates that targeted analysis methods miss nearly all the PFAS compounds in modern AFFF mixtures, thus underestimating the risk to human health and the environment.
sMRM Concurrency Calculator by Christie Hunter | Data acquisition, QTRAP / Triple Quad, SCIEX information, TechnologyThis excel sheet allows you to quickly estimate the MRM concurrency and approximate dwell time for your Scheduled MRM Algorithm acquisition method. Paste your MRM method with retention times into the input tab then calculate the Excel workbook. Plots will update to...
The risky business of aflatoxins in milk by Robert Di Lorenzo | Blogs, Food / BeverageIf you’re in the dairy or food testing business, you know the threat aflatoxins pose. Aflatoxins are a type of mycotoxin produced by Aspergillus parasiticus, aspergillus flavus , and rarely aspergillus nomius.1 These are likely the most extensively researched group of mycotoxins because of their adverse health effects.2 What’s more, they are widely found in a variety of crops, namely maize, tree nuts, and spices. Believed to be primarily caused by rising temperatures and humidity, these naturally occurring fungi grow on crops in the field, or during storage of feed and raw materials, where they can potentially produce toxins that enter the food chain.
Gain New Insights Into Human Spermatogenesis with this “Click & Easy” OneOmics Workflow by Fabienne Le Floch | Blogs, Life Science Research, ProteomicsA recent webcast by Charles Pineau, Director of Protim, IRSET, Rennes, France, demonstrates how you can use the OneOmics™ Platform as a "Click & Easy" workflow for integrating next-generation proteomics (NGP) data with next-generation sequencing (NGS) data. Dr....
Thanksgiving Menu: A Detectable Feast! by SCIEX Community | Blogs, Food / BeverageOn Thursday 26th November 2015, millions of households across the United States will sit down to a hearty traditional Thanksgiving meal. The Thanksgiving holiday is when people celebrate the blessings of the year, in particular the harvest.
Are there Antibiotics in your Thanksgiving Turkey? by SCIEX Community | Blogs, Food / BeverageTruth – the first turkey I ever cooked was still frozen when it hit our plates. I couldn’t figure out why that thing was taking so long to roast. Then it hit me. I forgot to defrost the bird. If I recall correctly, even the giblets were still in it. It was ten p.m. when I broke the news to my guests that the turkey was not happening. A pizza was ordered, and everyone breathed a sigh of relief that they would not be suffering from a bout of food poisoning.
Celebrate with a Pesticide Free Thanksgiving! by SCIEX Community | Blogs, Food / BeverageBefore you start wondering if you should buy organic ingredients this Thanksgiving, it is good to know regulating bodies set and monitor allowable pesticide limits within our food supply. Pesticides that help control pests, disease, and deter unwanted animals from eating supplies found in fields, mills, and facilities. How and when this testing takes place in the United States is overseen by the Environmental Protection Agency (EPA) according to five primary regulating statutes.
Keeping Up with Synthetic Cannabinoids Using Mass Spec by SCIEX Community | Blogs, ForensicFacts about Synthetic Cannabinoids and why you need to pay attention to evolving science
Mass Spectrometry Helps Researchers Solve a Mystery about Type 2 Diabetes Drug by sara.feltesse@sciex.com | Blogs, Life Science Research, ProteomicsThis is an article from November 21, 2013. We thought it was an interesting story to share with you on this World Diabetes Day. For the research conducted by the Australian and Canadian researchers, the analysis at the molecular level was optimized on SCIEX instrumentation, including the SCIEX TripleTOF® 5600 and the SCIEX QTRAP® 5500 system
Top Three Ways SCIEX has fun with Halloween Candy by SCIEX Community | Blogs, Food / BeverageHalloween is the time for lots of trick or treats ranging from chocolate bars to lollipops and oh so good candy corn. However, come October 31, it is time to mind sneaky ingredients that have the best disguise of all. From pork extracts, artificial sweeteners, to stuff that is hard to pronounce, SCIEX digs up some of our recent Food and Beverage studies for some ghoulishly good fun.
The Top Ten Things Scientists Think about on Halloween by SCIEX Community | Blogs, Food / BeverageThe Top Ten Things Scientists Think about on Halloween
Analyze Large Omic Data Sets with Cloud Computing and See What More You Can Accomplish by SCIEX Community | Blogs, Life Science Research, ProteomicsOur scientific world is expanding. With each passing day, new discoveries are made, old discoveries are verified, and more data are generated. Large data sets are now the norm for omics experiments such as genomics, transcriptomics, proteomics, and metabolomics....
Simultaneous Detection of Multiple Species in Meat Using LC-MS/MS Technology by SCIEX Community | Blogs, Food / BeverageSmart food shopping starts with labels. However, what if we told you the ingredient list may not be all that it seems? According to Food Safety News, producers are sneaking lower quality ingredients into our food to save money. This type of food fraud is estimated to cost the global food industry $10 to $15 billion per year. If you think back to the Middle Ages, even our ancestors were consumed with cost savings by inserting nutshells, seeds, berries, and more within their spices.
Using Mass Spectrometry to Screen Hundreds of Known and Unknown Metabolites by Baljit Ubhi | Blogs, Life Science Research, MetabolomicsIn the field of metabolomics, you typically choose to identify and characterize as many compounds as possible in an unbiased fashion, or screen for a specific set of compounds that are biologically relevant to your research. The beauty of the TripleTOF® System is that...
MultiOmics Research For the Study of Placental Development by Fabienne Le Floch | Blogs, Life Science Research, ProteomicsA recent study by Katy Williams (UCSF), Christie Hunter (SCIEX), and Andrew Olsen (Advaita) used the iPathwayGuide within the OneOmics cloud computing environment to help understand how placental development can go awry during certain pregnancy complications such as pre-eclampsia.
This LC-MS/MS Application Detects Almond and Peanut Allergens in Spices by SCIEX Community | Blogs, Food / BeverageIf you suffer from peanut allergies, you may want to think twice before diving into a bowl of something spicy. The reason being, some shipments of North American and European products containing ground cumin, cumin powder, cayenne pepper, paprika, and pilli-pilli...
Mass Spectrometry Detects Very Low Levels of Chemical Compounds in Asia Pacific Waters by SCIEX Community | Blogs, Food / BeverageDid you know that even though most of the world is covered in water, access to clean drinkingwater remains a problem? Take Asia for example where 62,000 people have lost their lives between 2001 and 2005 due to water-related disaster and illness. Clean water is...
Simultaneously Detect Different Types of Beer Microbes Using XP-PCR by SCIEX Community | Blogs, Food / BeverageSpoiler Alert – How to Save Time Testing for Bacteria in Beer? Nothing ruins a batch of beer worse than bacteria, specifically Pediococcus and Lactobacillus. Too much of these hop resistant genes can get carried away causing spoilage and sour beer. It is why breweries...