Boar taint isn’t so simple by SCIEX Community | 0 Comments The title says it all. Boar taint is a complex subject. For some, it’s not an issue. Others argue that it’s one of the biggest challenges to pork quality. It’s a very subjective response. In her blog, Dr. Laura Hancox illustrates the striking difference between the...
A beginner’s instrumentation guide to cannabis analysis by Paul Winkler | 0 CommentsOne question I get asked a lot when it comes to cannabis, specifically regarding marijuana and hemp analysis, is: There are so many techniques to choose from, how do I know which one is best? I can’t emphasize enough that the Cannabis sativa plant has a complex...
Worth the Journey – From Immunoassay to LC-MS/MS Adoption by SCIEX Community | 0 CommentsThe journey to mass spectrometry (LC-MS/MS) adoption from immunoassay can be complicated, but certainly rewarding. While immunoassay has been considered the default methodology for decades, they can be susceptible to interferences and cross-reactivity, especially for...
Journey to the Center of the Vape – Part 1 by Paul Winkler | 0 CommentsThe safety of vaping has recently become a topic of concern. The public wants answers about the safety of these products. Health authorities are scrambling to find the cause of the mysterious vaping illness that has been seen in hundreds of cases across the U.S., and...
An overview: LC-MS analysis of targeted protein degraders and their metabolites by Kirsten Craven | Blogs, Pharma, ZenoTOF 7600 systemTargeted protein degraders (TPD) are a relatively new therapeutic modality that opens the potential to target disease-causing proteins. These disease-causing proteins have been highly challenging for traditional small-molecule therapeutics to treat, making TPDs an exciting new therapeutic modality.
Guide decisions during cell line development with more information at the intact level by Roxana McCloskey | Biopharma, Blogs, Intabio ZT system, ZenoTOF 7600 systemMonitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to provide more information, it is possible to improve product quality and manufacturing efficiency and make more informed decisions.
Processing ZenoTOF 7600 system data with DIA-NN software by Christie Hunter | Data processing, Life Science Research, Proteomics, SCIEX information, ZenoTOF 7600 systemDIA-NN software is a powerful software tool for processing data independent acquisition (DIA) proteomics datasets. It uses neural networks and other algorithms to identify and quantify peptides and proteins from DIA data and is specifically optimized for fast...
Meat vs plant based. What is the best option? by SCIEX Community | Blogs, Food / Beverage, Food and BeverageAs we become more conscious about the planet, healthier lifestyles and our duty to protect the environment, attitudes and behaviours are shifting when it comes to food consumption.
How is the protein level fold-change computed on proteomics data using Assembler app? by Christie Hunter | Algorithms, Life Science Research, OneOmics, Proteomics, QTOF, SCIEX information, ZenoTOF 7600 systemWith bottom-up proteomics, we quantify peptides in the sample and then infer the protein level quantitation from that data. However, due to post-translational modifications, different protein isoforms, etc. we don’t always expect that all peptides associated with the...
Computing protein confidence with improved accuracy by reassessing peptide confidence during protein grouping by Christie Hunter | Data processing, Life Science Research, ProteinPilot, Proteomics, QTOF, SCIEX information, ZenoTOF 7600 systemProteinPilot software 4.0 and higher releases include a new method for calculating protein confidences that improves reliability at the end of protein lists. Figure 1 shows a simulated example that demonstrates how more accurate protein confidence is computed. Figure...
Intabio acquisition expands SCIEX portfolio of impactful solutions to accelerate biotherapeutic development by Community Manager | Biopharma, BlogsDue to the nature of their production, biotherapeutics are difficult to manufacture. Growth conditions, purification protocols and formulation requirements can introduce unintended modifications into the protein structure that may affect its efficacy and safety.
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready by Jianru Stahl-Zeng | Blogs, ClinicalSensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
The honey sting by Katherine Hyland | Blogs, Food / BeverageAs a consumer it’s hard for me not to feel inundated with claims that our food is “all-natural” or “chemical-free” or that we should buy certain “superfoods” for their health benefits. We read labels and trust that the product we are buying is what we are truly...
Innovation that’s blasting through limitations in explosive detection by Pierre Negri | Blogs, ForensicMass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
“Bottoms Up” Proteomics by Tom Knapman | Blogs, Life Science Research, Proteomics Ahhhh beer. It's a ubiquitous drink found in over 90% of all countries around the world. Since the dawn of civilization, man has celebrated with beer where it can make even the most introverted person suddenly dance a little jig or belt out a top 40 song. But other...
Now You Can Overcome Your Food and Environmental Testing Obstacles by SCIEX Community | Blogs, Environmental / Industrial, Food / BeverageHow do you safeguard human health and protect your reputation through meeting stringent global food and environmental safety standards? When it comes to testing food and environmental samples, the quality of your testing data is vital to your business. You need fast...
Unraveling the Metabolome by SCIEX Community | Blogs, Life Science Research, MetabolomicsDr. David Wishart, Departments of Biological Sciences and Computing Science, University of AlbertaCanada’s TMIC is an internationally-recognized leader in metabolomics, providing tools and resources that are used by laboratories around the world. The center offers...
It’s Time to Stop Fraudulent Food Reaching the Consumer with LC-MS/MS by SCIEX Community | Blogs, Food / BeverageIf you are reading this blog, it is likely that you are fully acquainted with food fraud, but let’s just take a moment to set the scene. Food fraud is by no means a new phenomenon and goes as far back as the middle ages, with the concept of tampering or...
Product Quality Assessments of Biotherapeutics Using LC-MS MAM by SCIEX Community | Biopharma, BlogsWhy LC-MS MAM?The Liquid Chromatography-Mass Spectrometry Multiple Attribute Methodology (LC-MS MAM) is a technique that is quickly gaining traction in the development and manufacturing of biopharmaceuticals. But what exactly is MAM? As researchers describe in a...
Ion Formation Control Is the Key to Increasing System Robustness by SCIEX Community | Blogs, TechnologyTraditional mass spectrometry ionization methods such as electronic spray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI), are popular methods for detecting the molecular weight of proteins, peptides, and other biologics. The reason being both...
Why You Need Mass Spec for Veterinary Drug Residue and Antibiotic Analysis by SCIEX Community | Blogs, Food / BeverageAs hospitals struggle with increasingly hard-to-treat antimicrobial resistance (ARM) bacterial infections, related deaths now exceed 700,000 per year globally and are predicted to reach 10 million per year by 2050. There’s no denying that these statistics are both...
Simplify Your Life with a Streamlined Workflow for Multiple Attribute Methodology (MAM) by Sean McCarthy | Biopharma, BlogsThe effort to fully characterize and release a biotherapeutic to the market can be onerous. Typically, many tests are required to identify and monitor various attributes of the final product in order to ensure the safety and efficacy of the drug. These product quality...
Solving the Mystery of Forensic Quantitative Analysis by SCIEX Community | Blogs, ForensicWhy You Need Differential Mobility Spectrometry for Forensic Mass Spec Analysis Forensics depend on detection of even the smallest compounds to deliver results you can rely on. You need fast analysis methods that provide highly accurate data across a multitude of...
Calling all Bioanalysts: We’re Making Bioanalytical Selectivity Challenges History by SCIEX Community | Biopharma, Blogs, PharmaHigh selectivity is a key component of successful quantitative bioanalysis. As a bioanalyst, we need consistently accurate and robust quantitation of small molecule therapeutics and metabolites. Challenged by complicated matrix interferences, high baseline signal, and...
The Latest and Greatest for Improving Lipidomic Analysis by Mass Spectrometry by Mackenzie Pearson | Blogs, Life Science Research, LipidomicsDifferential Mobility Separation (DMS) resolves multiple lipid classes within complex lipid matrices prior to MS analysis to enable more confident identification of lipid species and more accurate quantitation by MS/MS. Lipidomics research has progressed rapidly in...
Out with the “If it Ain’t Broke, Don’t Fix it” Approach. In with Remote Monitoring. by SCIEX Community | Blogs, Software, TechnologyOften by the time you’re aware of a problem, it’s too late, and disaster has already struck. You’re forced to pick up the pieces—downtime, reduced productivity and lost data. When your PC goes down, IT comes to the rescue. That’s a reactive approach. In many cases, IT...
Increase your Lab’s ROI with Remote Monitoring Service for SCIEX LC-MS Systems by SCIEX Community | Blogs, Software, TechnologyLike most organizations, your lab is likely thinking about ways to reduce costs and maximize profits.If so, keep in mind that no matter your area of research, sample volume or locations, remote monitoring services can make a difference in yearly maintenance...
SWATH Acquisition: A Step Closer to Unravelling the Opioid Puzzle by SCIEX Community | Blogs, ForensicDrug overdose has become one of the leading causes of death of Americans under 50. If that’s not bad enough, let’s put this into perspective. America makes up only 4% of the world population. In 2015, it recorded 52,400 drug-related deaths, which is about 27% of the...
Greater uptime equals higher productivity by SCIEX Community | Blogs, Software, TechnologyIn the old days, if you wanted to monitor your lab’s data, you would either remain by your instrument as long as it took to complete the sample run or dial-in via a telephone modem. Neither option, however, offered much in the way of enhancing productivity. Today’s...
Simplifying Polar Pesticides Within a Single Analysis by SCIEX Community | Blogs, Food / BeverageGlyphosate is a polar pesticide widely used as a garden herbicide. It is an ingredient in the world’s bestselling weed killer, which farmers consider one of their best solutions to their super weed problems. However, the chemical has become one of the most...
The Ultimate Selectivity for Peptide and Protein Quantitation by SCIEX Community | Biopharma, Blogs, Life Science Research, Proteomics, Technology There’s no doubt about it, biopharma drug development is experiencing phenomenal growth and presents a variety of challenges not experienced in small molecule development. Some of these challenges are in the selective and sensitive quantitation of peptides and...
5 Applications That Benefit from a New Dimension in Selectivity by SCIEX Community | Blogs, TechnologyMass spectrometry can provide exceptional sensitivity, selectivity, resolution, throughput, and mass accuracy, but certain applications demand additional levels of selectivity. This is where differential ion mobility technology comes in. It delivers highly-selective,...
Screening Food for Allergens Using LC-MS/MS Analysis by Philip Taylor | Blogs, Food / BeverageBrowse the shelves of any grocery store, and you may get a false sense of security when it comes to ingredient lists. As much as consumers want to trust labels, the truth is, food products could contain mislabelled ingredients, such that they trigger an allergic reaction with serious detrimental effects including discomfort, pain sickness and in some instances, death. Manufacturers, however, do not want to risk their reputation and consumer safety over a false label. As such, there must be some sort of verification to support such an action
4 Reasons Why Your Lab Needs Remote Monitoring by SCIEX Community | Blogs, Software, TechnologyYou know the drill, lab managers are always seeking new solutions to keep their labs running at peak performance and instrument or system disruptions can be detrimental. Wouldn’t it be nice if there were a way to connect to your lab from anywhere securely and to stay ahead of potential instrument problems? By using remote monitoring, labs are now able to respond to issues quickly and efficiently, productively reducing downtime.