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High complexity of the lipidome
The complexity of the lipidome is diverse in the structure and there are many combinatorial isoforms that are available within nature. Currently, many different techniques are required to fully characterize a lipid molecule. What if you could do it in a single experiment using electron activated dissociation (EAD) on the ZenoTOF 7600 system. Learn more […]
Tags: activate, character, community, complexity, computer, dissociate, electron, embed, engineering, experiment, language, machine, molecule, science, separate, single, software, technology, use
August 10, 2021
Standard front-end cleaning for TripleTOF systems
General points: Use of laboratory deionized (DI) water is specified at points in the procedure. However, if there are any concerns regarding quality, please utilize a reputable supplier of pure deionized water (>18.2M ohm). 5-10 liters will typically be required to perform cleaning and rinsing steps. If there are any concerns regarding tap water quality […]
Tags: bag, brush, clean, clean beaker, cleaning, di water, job, period, place qj, position, rinse, room, solution, space, tap, tap water, time, TripleTOF, use, water, water rinse, white, wipe
Simple tests for determining whether to clean your QJet ion guide and IQ0 Lens on your TripleTOF system
Assessing the linear response of ITCÂ (dynamic ion transmission control) is an easy way to determine whether you should clean your QJet ion guide and IQ0 lens. A clean rod set and lens should give a linear response when ramping the ITC parameter and the ratio of 132 to 829 should remain the same. Here […]
Tags: TripleTOF
Having issues differentiating CBD from THC in hemp-derived products?
The popularity of CBD products has been on the rise following a federal move to legalize hemp. In an effort to regulate the sale of hemp-derived products in the United States, the government legalized CBD derived from hemp that contains no more than 0.3% THC by dry weight. Although hemp-derived CBD is now federally legal, […]
Tags: Hemp
August 8, 2021
Need a reliable, crowd-sourced HR-MS database for screening Novel Psychoactive Substances (NPS)?
The recent influx of novel psychoactive substances (NPS) into the recreational drug market has posed a serious burden to public health. The availability of these substances through the Internet has contributed to the widespread of NPS globally, raising great concern as little to no scientific information is available on them. As a result, it has […]
Tags: LibraryView, NPS
Looking for an educational podcast on forensic toxicology?
Listen to the Toxpod, an informative podcast about the many facets of the field of forensic toxicology created by Tim Scott and Peter Stockham, two forensic toxicologists working for the South Australian government. Produced by Forensic Science South Australia and the South Australia’s General’s Department, this educational podcast covers many topics of the field of […]
Stay informed on the latest novel psychoactive substances (NPS) flooding the US drug market
Each year, the Drug Enforcement Administration (DEA) Special Testing and Research Laboratory publishes an Emerging Threat Report. The data contained in the report is updated quarterly and represents a snapshot of the drug evidence seized and analyzed by the DEA in the designated period. The report is a comprehensive representation of the NPS market in […]
Tags: book, data, detection, drug, drug market, drug type, emergence, emerging, fentanyl, health, information, knowledge, market, novel, NPS, number, opiods, report, report drug, research, science, substance, swath, time, use, work
How does Collision Energy Spread work on the SCIEX QTOF, TripleTOF, and ZenoTOF systems?
Collision energy spread (CES) generates a collision energy (CE) ramp around a collision energy center point, with the goal of providing a more, rich MS/MS spectrum of your analytes. The CE center point is either set in your acquisition method or computed on the fly using rolling collision energy (for peptide workflows). When building your […]
How can I tell if my Spectral Peak is saturated on the TripleTOF system?
The key performance attributes for qualitative analysis are speed, mass accuracy, and resolution in both MS and MS/MS modes. For quantitative analysis, inter-scan dynamic range is important in order to maintain accuracy and linear response over a wide range of sample concentrations. The detection system on a TripleTOF system is a key component to achieving […]
Tags: saturation
How does Dynamic Ion Transmission Control (DITC) work on the TripleTOF systems?
Dynamic Ion Transmission Control (ITC) is the feature on all the QTOF systems from SCIEX where the MS ion current through the instrument is modulated scan by scan to ensure the detector saturation point is not reached. The modulation is done both at the level of total # of ions in a scan but also […]
Tags: DITC, transmission
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