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What is your Method for Separating Challenging Polar Molecules?
From small ions like phosphate, herbicide degradation to metabolites, oligosaccharides, peptides, and proteins. How is your lab analyzing polar molecules? The reason I ask is there is a saying, if you have a charged or polar molecule, look to capillary electrophoresis (CE) first. While liquid chromatography (LC) is an ideal front-end separation tool for many types of molecules, as the following poster points out, “From Small to Very Large, Orthogonal, Sensitive Polar Molecule Analysis by CESI-MS,” there are some situations that call for CE over LC analysis. For those of you that are not familiar with CESI-MS, it is the combining of CE separation with electrospray ionization, into one dynamic process, within the same device.
Tags: Biopharma, biotherapeutic development, blaze, charge, company, couple, development, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
May 22, 2017
The Trouble with PFAS in Drinking Water
There has been a string of news articles concerning polyfluorinated alkyl substances (PFAS) in drinking water these days, and I must say, they have my attention. Here is the thing, when you think of drinking water in the United States, for example, crystal clear lakes, rivers, and groundwater along with effective water treatment come to mind. On the flip side, as safe, some supplies may be there are communities such as that of Flint, Michigan, which have been dealing with lead filled pipes for far too long. Contamination was so bad there that residents were provided bottled water for drinking purposes as the state decided who was responsible for replacing the affected water lines.
Tags: biotherapeutic development, blaze, charge, company, couple, development, Environmental, Food / Beverage, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
April 28, 2017
SWATH Acquisition – Master of All Trades
SWATH® Acquisition is an innovative strategy for acquiring data on a TripleTOF® mass spectrometer. In a previous blog, we learned how SWATH works. Now let’s learn what it can do for different applications:
Tags: application, company, computer, different, form, guide, information, ion, job, machine, mass, method, option, research, science, sensitivity, system, time, triple, TripleTOF Systems, work, X500B System, X500R System
April 19, 2017
The Power Behind LC-MS for Quantifying mAb Therapeutics
Quantitation of monoclonal antibodies (mAbs) in biological fluids is important during all stages of antibody drug development. First developed in the 1970s, therapeutic mAbs have both research and medicinal impact as they can be used for diagnosis and treatment of a wide variety of diseases, and have a high level of specificity.
Tags: Biopharma, biotherapeutic development, blaze, charge, company, couple, development, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
Data Independent Acquisition Mass Spectrometry with the Power of SWATH
There are many different methods in use today to acquire data on a mass spectrometer, but few have generated as much buzz in recent years as SWATH technology. First reported 5 years ago by Ruedi Aebersold and his group1, SWATH® Acquisition on a TripleTOF® instrument has rapidly become one of the premier acquisition strategies for identification and quantitation of complex samples. But what exactly is SWATH and why is it so powerful? In order to answer these questions, let’s first take a step back and look at the larger picture.
Tags: application, company, computer, different, form, guide, information, ion, job, machine, mass, Metabolomics, method, option, Proteomics, research, science, sensitivity, system, time, triple, TripleTOF Systems, work
April 6, 2017
Volumetric Absorptive Microsampling and the SCIEX 6500+: A Pre-Clinical Case Study for the Biotherapeutic Exenatide
In an effort to Replace, Refine, and Reduce the number of animals used for pre-clinical research, several microsampling strategies have been implemented which allow for the consolidation of satellite TK and main study groups. In addition to the ethical gains driven by these 3Rs, microsampling has the potential of increasing scientific value since it becomes feasible to directly correlate exposure, toxicological effects and pharmacological response in the same individual
Tags: Biopharma, biotherapeutic development, blaze, charge, company, couple, development, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
April 3, 2017
Say Goodbye to MetID Headaches, Say Hello to Automated Large Molecule Catabolism Processing
Is your mind swimming with large molecule catabolism data? Do you spend hours manually processing through complex spreadsheets to match your data with theoretical biologic catabolites? Are you wasting precious time by drawing out and processing your therapeutic peptide as a small molecule? Are you worried that you could be missing something?
Tags: Biopharma, biotherapeutic development, blaze, charge, company, couple, development, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
March 29, 2017
Using the X500R QTOF System and SCIEX OS to Identify and Quantify Food Residues
Farmers use pesticides to protect crops from insects and disease as pesticides are necessary to create the volume of food that our population requires. Without them, we would not be able to grow enough crops to feed the world—they are a necessary evil. Government agencies such the Food and Drug Administration (FDA) in the United States and pesticide manufacturers, however, work hard to educate farmers on how to minimize their use. However, sometimes farmers add too much which leaves a residue. Upon harvest, farmers wash the fruit and vegetables. Once complete the crop then makes its way to the wholesaler and eventually, the supermarket. Even so, there may still be pesticide residue on the produce, which is why government agencies randomly pull produce from store shelves for testing of maximum residual limits (MRLs) and we are encouraged to wash our food before consuming it
Tags: biotherapeutic development, blaze, charge, company, couple, development, Food / Beverage, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
March 27, 2017
The World Has its Eyes on Precision Medicine
What if we could understand and then treat diseases on an individualized level, in a way that was tuned to a person’s individual biology? Not in a futuristic, ‘wave a high-tech scanner across a person’s body’ way, but in a legitimate ’I can run a lab test and know the best action to take’ way. This is the promise of Precision Medicine, to deliver the right treatment to the right patient, at the right time, predicting more accurately which treatments will work for certain groups of patients, in contrast to the pervasive one-size-fits-all approach. More specifically, if we could provide a comprehensive report at the molecular level of an individual (based on genome, proteome, or metabolome profiles), a physician could be much better informed to make optimal treatment decisions. And if we could track these profiles over time, a person could adjust their lifestyle to focus on long-term wellness.
Tags: biotherapeutic development, blaze, charge, company, couple, development, job, machine, mass, money, new, number, power, protein, Proteomics, rapid, system, technology, time, variant, work
March 24, 2017
Setting Records with Fast Glycan Technology
There is a lot of talk going around in the lab, and it has to do with the newly released Fast Glycan Labeling and Analysis technology. Where once research analysts needed to set aside days to perform glycan analysis, now takes an hour or so. Glycans are immediately identified by the software – so no need for data interpretation. That’s up to 5x faster than HILIC.
Tags: Biopharma, biotherapeutic development, blaze, charge, company, couple, development, job, machine, mass, money, new, number, power, protein, rapid, system, technology, time, variant, work
March 17, 2017
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