Application of CGE in cell and gene therapy by Kerstin Pohl | 0 CommentsIn a recent webinar, available on demand, scientists Luiza Chrojan and Ryan Hylands from Pharmaron, provided insights into the deployment of capillary gel electrophoresis (CGE) within cell and gene therapy. Luiza and Ryan shared purity data on plasmids used for adeno-associated virus (AAV) manufacturing and data on AAV genome integrity, viral protein (VP) purity and VP ratios using the BioPhase 8800 system.
From exposure to discovery: How SWATH DIA can enhance our understanding of the exposome and its impact on health by Rebekah Sayers | 0 CommentsLast year, Technology Networks hosted two webinars that featured groundbreaking research utilizing SWATH DIA (data-independent acquisition) for exposomics and metabolomics. Researchers Dr. Vinicius Verri Hernandes from the University of Vienna and Dr. Cristina Balcells from Imperial College London (ICL) demonstrated how a DIA approach can be successfully implemented in small molecule analysis using the ZenoTOF 7600 system. Their innovative approaches highlight the potential of SWATH DIA to enhance the detection and analysis of chemical exposures and metabolites, paving the way for new insights into environmental health and disease mechanisms.
PFAS testing: 2024 in review and what to expect for 2025 by SCIEX Community | 0 CommentsFor as long as PFAS persist in the environment, there is no doubt they will persist in our conversations as environmental scientists. Globally, PFAS contamination has been detected in water supplies, soil and even in the blood of people and wildlife. Different countries are at various stages of addressing PFAS contamination and many governments have set regulatory limits and are working on assessing the extent of contamination, cleaning up affected sites and researching safer alternatives.
Inside the box: Acoustic ejection mass spectrometry for drug discovery by Kirsten Craven | 0 CommentsOn average, it takes 10-15 years and 1-2 billion dollars to approve a new pharmaceutical for clinical use. Since approximately 90% of new drug candidates fail in clinical development, the ability to make early, informed and accurate decisions on the safety and efficacy of new hits and leads is key to increasing the chances of success.
Application of CGE in cell and gene therapy by Kerstin Pohl | Biopharma, BioPhase 8800 system, BlogsIn a recent webinar, available on demand, scientists Luiza Chrojan and Ryan Hylands from Pharmaron, provided insights into the deployment of capillary gel electrophoresis (CGE) within cell and gene therapy. Luiza and Ryan shared purity data on plasmids used for adeno-associated virus (AAV) manufacturing and data on AAV genome integrity, viral protein (VP) purity and VP ratios using the BioPhase 8800 system.
From exposure to discovery: How SWATH DIA can enhance our understanding of the exposome and its impact on health by Rebekah Sayers | Blogs, Life Science Research, ZenoTOF 7600 systemLast year, Technology Networks hosted two webinars that featured groundbreaking research utilizing SWATH DIA (data-independent acquisition) for exposomics and metabolomics. Researchers Dr. Vinicius Verri Hernandes from the University of Vienna and Dr. Cristina Balcells from Imperial College London (ICL) demonstrated how a DIA approach can be successfully implemented in small molecule analysis using the ZenoTOF 7600 system. Their innovative approaches highlight the potential of SWATH DIA to enhance the detection and analysis of chemical exposures and metabolites, paving the way for new insights into environmental health and disease mechanisms.
PFAS testing: 2024 in review and what to expect for 2025 by SCIEX Community | Blogs, Environmental / IndustrialFor as long as PFAS persist in the environment, there is no doubt they will persist in our conversations as environmental scientists. Globally, PFAS contamination has been detected in water supplies, soil and even in the blood of people and wildlife. Different countries are at various stages of addressing PFAS contamination and many governments have set regulatory limits and are working on assessing the extent of contamination, cleaning up affected sites and researching safer alternatives.
Inside the box: Acoustic ejection mass spectrometry for drug discovery by Kirsten Craven | Blogs, Discovery, Echo MS, Pharma, QA/QCOn average, it takes 10-15 years and 1-2 billion dollars to approve a new pharmaceutical for clinical use. Since approximately 90% of new drug candidates fail in clinical development, the ability to make early, informed and accurate decisions on the safety and efficacy of new hits and leads is key to increasing the chances of success.
Unveiling the power of ZT Scan DIA: Insights from Ludwig Sinn’s presentation at World HUPO Congress 2024 by Rebekah Sayers | Blogs, Life Science Research, Proteomics, ZenoTOF 7600 systemIn a recent presentation at the World HUPO Congress 2024, Ludwig Sinn from the Ralser lab shared exciting advancements in proteomics research, focusing on the innovative ZT Scan DIA acquisition modes developed in collaboration with SCIEX. Let us explore the key highlights and benefits of this innovative technology.
Exploring the power of ZT Scan DIA by Rebekah Sayers | Blogs, Life Science Research, Proteomics, ZenoTOF 7600+ systemIn a recent presentation, Tim Heymann from Mann Lab at the Max Planck Institute of Biochemistry shared his first impressions of ZT Scan DIA, the novel data-independent acquisition strategy from SCIEX, highlighting its innovative approach and significant benefits for proteomics research. Let’s dive into the key points from his insightful talk.
Inside the box: Complementary fragmentation with LC-MS for Metabolite Identification by Kirsten Craven | Blogs, Pharma, ZenoTOF 7600 systemLiquid chromatography-mass spectrometry is commonly used for Met ID but confident soft spot identification is not always possible. Imagine the advantage of unambiguous metabolite identification using liquid chromatography-mass spectrometry (LC-MS) reducing the need for additional safety testing during drug discovery. Quickly and easily generate the information you need using routine assays that are robust and efficient, enabling confident decision-making while also saving time and money.
Tips and tricks from our application experts: AAV analysis with CE by Peter Holper | Biopharma, BioPhase 8800 system, Blogs, PA 800 systemPeter Holper, Staff Applications Scientist at SCIEX, US, shares his tips and tricks on AAV analysis using CE with the BioPhase 8800 system and the PA 800 Plus system.
Selecting an LC-MS system for quantitation of pharmaceutical drug development by Kirsten Craven | Blogs, Echo MS, Pharma, QTRAP / Triple Quad, ZenoTOF 7600 systemWe understand you are busy, needing to prioritize running instruments, reporting results and managing your laboratory to meet deadlines. We created a solution guide to explain how SCIEX systems fit in the drug development pipeline to save you time evaluating options.
Celebrating customer experience: Insights from SCIEX leaders by Philip Taylor | Biopharma, Blogs, Clinical, Environmental / Industrial, Food / Beverage, Forensic, Life Science Research, Pharma, TechnologyIntroduction Customer Experience Day (CX Day) is a special occasion for SCIEX, celebrated every first Tuesday in October. It’s a day dedicated to recognizing the incredible value of our customers and the relentless dedication of our associates who strive to make...
Automation integration for the Echo® MS system by Christie Hunter | Echo MS, Sample Preparation, SCIEX information, TechnologyThe Echo® MS system is specifically designed to be compatible with a variety of automation options to allow labs the flexibility to personalize their setup to meet their specific needs. To help you make the best decisions for your own lab, here are the answers to some...
Standard front-end cleaning for TripleTOF systems by Christie Hunter | Instrument maintenance, QTOF, SCIEX information, TechnologyGeneral points: Use of laboratory deionized (DI) water is specified at points in the procedure. However, if there are any concerns regarding quality, please utilize a reputable supplier of pure deionized water (>18.2M ohm). 5-10 liters will typically be required...
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready by Jianru Stahl-Zeng | Blogs, ClinicalSensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
A rising star in food allergen research: proteomics of shellfish allergen by SCIEX Community | Blogs, Food / Beverage, Life Science Research, ProteomicsIt’s important to know what you’re eating, especially if you suffer from a food allergy. About 220 million people worldwide live with a food allergy.1 These numbers, along with the complexity and severity of conditions, continue to rise. In America, there are about 32 million food allergy sufferers—5.6 million of those are children under the age of 18.2.2 That’s 1 out of every 13 children, or about 2 in every classroom. From a financial perspective, the cost of food allergy childcare for US families is up to $25 billion