Accurate mass LC-MS/MS for PFAS analysis without needing a blockbuster budget by Craig Butt | 0 CommentsIf you’ve been following our recent blogs, you’ve probably seen quite a bit on how per- and polyfluoroalkyl substances (PFAS) are shaking up both the food and environmental industry. Even if you’ve not been following our blogs, you’ve probably seen a lot of media...
A rising star in food allergen research: proteomics of shellfish allergen by SCIEX Community | 0 CommentsIt’s important to know what you’re eating, especially if you suffer from a food allergy. About 220 million people worldwide live with a food allergy.1 These numbers, along with the complexity and severity of conditions, continue to rise. In America, there are about 32 million food allergy sufferers—5.6 million of those are children under the age of 18.2.2 That’s 1 out of every 13 children, or about 2 in every classroom. From a financial perspective, the cost of food allergy childcare for US families is up to $25 billion
Routine cannabis screening is here. Will your lab reap the benefits? by Paul Winkler | 0 CommentsFast, accurate, and robust solution for routine commercial cannabis testing As the world debates cannabis legalization for therapeutic applications and recreational use, the trends are shifting. Medicinal use of cannabis is legal in an increasing number of countries worldwide, including 33 states and the District of Columbia in the United States. Uruguay was the first country in the world to legalize the sale, cultivation, and distribution of cannabis in 2013. In the United States, Washington and Colorado were the first to fully legalize cannabis in 2012. By the end of 2019, 10 states have legalized recreational use for adults over the age of 21, with 64% of Americans favoring the move
Keep up with fentanyl and its analogs: Failure to do so is not an option. by Pierre Negri | 0 CommentsFentanyl is one of the most well-known synthetic opioids that has been in the spotlight lately—and not for good reasons. The World Drug Report 2019 reveals that there have been more than 47,000 opioid overdose deaths in the United States in 2017. This is an increase...
Application of CGE in cell and gene therapy by Kerstin Pohl | Biopharma, BioPhase 8800 system, BlogsIn a recent webinar, available on demand, scientists Luiza Chrojan and Ryan Hylands from Pharmaron, provided insights into the deployment of capillary gel electrophoresis (CGE) within cell and gene therapy. Luiza and Ryan shared purity data on plasmids used for adeno-associated virus (AAV) manufacturing and data on AAV genome integrity, viral protein (VP) purity and VP ratios using the BioPhase 8800 system.
From exposure to discovery: How SWATH DIA can enhance our understanding of the exposome and its impact on health by Rebekah Sayers | Blogs, Life Science Research, ZenoTOF 7600 systemLast year, Technology Networks hosted two webinars that featured groundbreaking research utilizing SWATH DIA (data-independent acquisition) for exposomics and metabolomics. Researchers Dr. Vinicius Verri Hernandes from the University of Vienna and Dr. Cristina Balcells from Imperial College London (ICL) demonstrated how a DIA approach can be successfully implemented in small molecule analysis using the ZenoTOF 7600 system. Their innovative approaches highlight the potential of SWATH DIA to enhance the detection and analysis of chemical exposures and metabolites, paving the way for new insights into environmental health and disease mechanisms.
PFAS testing: 2024 in review and what to expect for 2025 by SCIEX Community | Blogs, Environmental / IndustrialFor as long as PFAS persist in the environment, there is no doubt they will persist in our conversations as environmental scientists. Globally, PFAS contamination has been detected in water supplies, soil and even in the blood of people and wildlife. Different countries are at various stages of addressing PFAS contamination and many governments have set regulatory limits and are working on assessing the extent of contamination, cleaning up affected sites and researching safer alternatives.
Inside the box: Acoustic ejection mass spectrometry for drug discovery by Kirsten Craven | Blogs, Discovery, Echo MS, Pharma, QA/QCOn average, it takes 10-15 years and 1-2 billion dollars to approve a new pharmaceutical for clinical use. Since approximately 90% of new drug candidates fail in clinical development, the ability to make early, informed and accurate decisions on the safety and efficacy of new hits and leads is key to increasing the chances of success.
Unveiling the power of ZT Scan DIA: Insights from Ludwig Sinn’s presentation at World HUPO Congress 2024 by Rebekah Sayers | Blogs, Life Science Research, Proteomics, ZenoTOF 7600 systemIn a recent presentation at the World HUPO Congress 2024, Ludwig Sinn from the Ralser lab shared exciting advancements in proteomics research, focusing on the innovative ZT Scan DIA acquisition modes developed in collaboration with SCIEX. Let us explore the key highlights and benefits of this innovative technology.
Exploring the power of ZT Scan DIA by Rebekah Sayers | Blogs, Life Science Research, Proteomics, ZenoTOF 7600+ systemIn a recent presentation, Tim Heymann from Mann Lab at the Max Planck Institute of Biochemistry shared his first impressions of ZT Scan DIA, the novel data-independent acquisition strategy from SCIEX, highlighting its innovative approach and significant benefits for proteomics research. Let’s dive into the key points from his insightful talk.
Inside the box: Complementary fragmentation with LC-MS for Metabolite Identification by Kirsten Craven | Blogs, Pharma, ZenoTOF 7600 systemLiquid chromatography-mass spectrometry is commonly used for Met ID but confident soft spot identification is not always possible. Imagine the advantage of unambiguous metabolite identification using liquid chromatography-mass spectrometry (LC-MS) reducing the need for additional safety testing during drug discovery. Quickly and easily generate the information you need using routine assays that are robust and efficient, enabling confident decision-making while also saving time and money.
Tips and tricks from our application experts: AAV analysis with CE by Peter Holper | Biopharma, BioPhase 8800 system, Blogs, PA 800 systemPeter Holper, Staff Applications Scientist at SCIEX, US, shares his tips and tricks on AAV analysis using CE with the BioPhase 8800 system and the PA 800 Plus system.
Celebrating customer experience: Insights from SCIEX leaders by Philip Taylor | Biopharma, Blogs, Clinical, Environmental / Industrial, Food / Beverage, Forensic, Life Science Research, Pharma, TechnologyIntroduction Customer Experience Day (CX Day) is a special occasion for SCIEX, celebrated every first Tuesday in October. It’s a day dedicated to recognizing the incredible value of our customers and the relentless dedication of our associates who strive to make...
Detecting low levels of drugs and their metabolites in hair and nail samples using LC-MS/MS by SCIEX Community | Blogs, Forensic, ToxicologyYou probably have heard of testing blood and urine samples for the presence of drugs and their metabolites. But do you know about the benefits of hair and nail analysis? In a recent webinar, Tina Binz, Deputy Head of the Center for Forensic Hair Analysis, University of Zurich, discussed the benefits of developing comprehensive and sensitive LC-MS/MS for the detection of low-level drugs and metabolites in keratinized matrices.
It’s Time to Turn Things Around―Faster and Accurate Mass Analysis of Organic Explosives by SCIEX Community | Blogs, ForensicSadly, the world is a volatile place. The threat of organic explosive use by terrorists and criminals is very much with us, posing a significant danger to people worldwide. The rising concern for public safety is a top priority for national security organizations...
Push Your Research to the Cutting Edge: 2018 Global CESI-MS Symposium by Kelly May | Biopharma, Blogs, Life Science Research There are a lot of conferences vying for your attention every year. The Global CESI-MS Symposium on October 10-11 in the Netherlands is one you can’t afford to miss. It is the place to hear about the latest advancements made through the adoption of CESI-MS...
Break the routine: SCIEX OS-MQ improves your quantitation workflows by SCIEX Community | Blogs, Software, Technology Advances in today’s technology have resulted in a need for higher and faster sample throughput, with increasing number of measured analytes per sample. The new SCIEX OS-MQ software breaks the routine and takes quantitation workflows to a new level. Key features...
Stop Fumbling Around in the Dark: Try LC-MS/MS for Designer Drugs in Forensic Samples by SCIEX Community | Blogs, ForensicImagine being blindfolded, sent into a large (dark) room filled with obstacles and challenged to find an item, but you don’t know what that item is, and you have never seen it before. Then you must do the same again the next day, but you are looking for a different...
Something’s in the Water: Tackle Your PFAS Analysis by Craig Butt | Blogs, Environmental / IndustrialExposure to per- and polyfluoroalkyl substances (PFAS) residues could be dangerous. These chemicals have been linked to a variety of adverse health effects including liver damage, thyroid disease, decreased fertility, high cholesterol, obesity, hormone suppression,...
5 Reasons Why Mass Spec is Transforming Clinical Labs by SCIEX Community | Blogs, ClinicalAccording to the American Clinical Laboratory Association, more than 7 billion clinical lab tests are performed in the U.S. every year. While mass spectrometry represents only a fraction of the clinical applications, there are a growing number of tests where mass...
Save Effort. Save Time. Consolidate Your BioTherapeutic Quality, Safety, and Efficacy Assessments with One Direct LC-MS MAM Assay. by SCIEX Community | Biopharma, BlogsIn a previous blog, we learned how you could Simplify Your Life with a Streamlined Workflow for Multiple Attribute Methodology (MAM). Based on the well-known technique of peptide mapping, a Liquid Chromatography-Mass Spectrometry-based MAM workflow (LC-MS MAM) enables...
Metabolism and Biotransformation – What Are You Missing? by SCIEX Community | Blogs, PharmaAre you looking to improve your MetID studies? Want to achieve the productivity and throughput you need to keep your projects moving and have complete confidence that you’re not missing any low level or parent-like metabolites in your sample? In this blog, we’re...
Biologics Characterization: Intact and Subunit Mass Analysis by SCIEX Community | Biopharma, BlogsWhen All You Need Is Range – Mass Range, Dynamic Range, and the Complete Range Launching the best possible product in the shortest time possible is key for pharmaceutical companies like you. As you know, nearly every process throughout the biologics development cycle...
“Bottoms Up” Proteomics by Tom Knapman | Blogs, Life Science Research, Proteomics Ahhhh beer. It's a ubiquitous drink found in over 90% of all countries around the world. Since the dawn of civilization, man has celebrated with beer where it can make even the most introverted person suddenly dance a little jig or belt out a top 40 song. But other...
Now You Can Overcome Your Food and Environmental Testing Obstacles by SCIEX Community | Blogs, Environmental / Industrial, Food / BeverageHow do you safeguard human health and protect your reputation through meeting stringent global food and environmental safety standards? When it comes to testing food and environmental samples, the quality of your testing data is vital to your business. You need fast...
Unraveling the Metabolome by SCIEX Community | Blogs, Life Science Research, MetabolomicsDr. David Wishart, Departments of Biological Sciences and Computing Science, University of AlbertaCanada’s TMIC is an internationally-recognized leader in metabolomics, providing tools and resources that are used by laboratories around the world. The center offers...
It’s Time to Stop Fraudulent Food Reaching the Consumer with LC-MS/MS by SCIEX Community | Blogs, Food / BeverageIf you are reading this blog, it is likely that you are fully acquainted with food fraud, but let’s just take a moment to set the scene. Food fraud is by no means a new phenomenon and goes as far back as the middle ages, with the concept of tampering or...
Product Quality Assessments of Biotherapeutics Using LC-MS MAM by SCIEX Community | Biopharma, BlogsWhy LC-MS MAM?The Liquid Chromatography-Mass Spectrometry Multiple Attribute Methodology (LC-MS MAM) is a technique that is quickly gaining traction in the development and manufacturing of biopharmaceuticals. But what exactly is MAM? As researchers describe in a...
Ion Formation Control Is the Key to Increasing System Robustness by SCIEX Community | Blogs, TechnologyTraditional mass spectrometry ionization methods such as electronic spray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI), are popular methods for detecting the molecular weight of proteins, peptides, and other biologics. The reason being both...
Why You Need Mass Spec for Veterinary Drug Residue and Antibiotic Analysis by SCIEX Community | Blogs, Food / BeverageAs hospitals struggle with increasingly hard-to-treat antimicrobial resistance (ARM) bacterial infections, related deaths now exceed 700,000 per year globally and are predicted to reach 10 million per year by 2050. There’s no denying that these statistics are both...
Simplify Your Life with a Streamlined Workflow for Multiple Attribute Methodology (MAM) by Sean McCarthy | Biopharma, BlogsThe effort to fully characterize and release a biotherapeutic to the market can be onerous. Typically, many tests are required to identify and monitor various attributes of the final product in order to ensure the safety and efficacy of the drug. These product quality...
Solving the Mystery of Forensic Quantitative Analysis by SCIEX Community | Blogs, ForensicWhy You Need Differential Mobility Spectrometry for Forensic Mass Spec Analysis Forensics depend on detection of even the smallest compounds to deliver results you can rely on. You need fast analysis methods that provide highly accurate data across a multitude of...
Calling all Bioanalysts: We’re Making Bioanalytical Selectivity Challenges History by SCIEX Community | Biopharma, Blogs, PharmaHigh selectivity is a key component of successful quantitative bioanalysis. As a bioanalyst, we need consistently accurate and robust quantitation of small molecule therapeutics and metabolites. Challenged by complicated matrix interferences, high baseline signal, and...
The Latest and Greatest for Improving Lipidomic Analysis by Mass Spectrometry by Mackenzie Pearson | Blogs, Life Science Research, LipidomicsDifferential Mobility Separation (DMS) resolves multiple lipid classes within complex lipid matrices prior to MS analysis to enable more confident identification of lipid species and more accurate quantitation by MS/MS. Lipidomics research has progressed rapidly in...