Metabolite identification and peace of mind by Kirsten Craven | 0 CommentsManaging metabolite identification (Met ID) studies is challenging, so what is at the top of your priority list as you plan the year ahead? Ensuring you have the data needed to manage product safety, meeting deadlines, staff recruitment and training, maintaining compliance, capital expenses, or something else?
What has the Echo® MS system done for the pharma industry? (And don’t just take our word for it!) by Kirsten Craven | 0 CommentsSCIEX was very proud to have an illustration of the Acoustic Ejection Mass Spectrometry (AEMS) technology that powers the Echo® MS system on the front cover of the Journal of the American Society for Mass Spectrometry in January 2023. The associated article—Ultrahigh-Throughput Intact Protein Analysis with Acoustic Ejection Mass Spectrometry—was co-authored by scientists from SCIEX and Merck.
Methods for OPI electrode cleaning for Echo® MS system electrodes by Christie Hunter | 1 CommentDepending on the samples you are running on the system, it is possible for the Open Port Interface (OPI) electrode to become dirty or occluded over time. Below are two different cleaning strategies that can help you maintain your Echo® MS system and keep your OPI...
Tackling mycotoxin testing: Harnessing mass spectrometry for safer foods and healthier futures by SCIEX Community | Blogs, Food / Beverage, Food and BeverageProduced by certain moulds, thriving in crops such as grain, nuts and coffee, mycotoxins have contaminated agriculture and food production industries for a long time. To intensify the challenge, mycotoxins are resilient, not easily broken down and ensuring the safety of food supply chains requires comprehensive solutions and we are here to share those solutions with you.
Enhancing omics-based mass spectrometry workflows with Electron-Activated Dissociation (EAD) by Rebekah Sayers | Blogs, Life Science ResearchElectron-Activated Dissociation (EAD) is transforming the fields of metabolomics and lipidomics by providing enhanced fragmentation techniques that offer deeper insights into molecular structures. In September, Technology Networks hosted a webinar, “Enhancing Mass-Based Omics Analysis in Model Organisms,” featuring Dr. Valentina Calabrese from the Institute of Analytical Sciences at the University of Lyon. Valentina shared her insights on improving omics-based mass spectrometry analysis for toxicology studies using model organisms, particularly in metabolomics and lipidomics. This blog explores the additional functionalities EAD offers, its benefits in untargeted workflows, its incorporation into GNPS and molecular networking, and the future role it could play in these scientific domains.
The economics of food testing: A strategic perspective for laboratory managers by Philip Taylor | Blogs, Food / Beverage, Food and BeverageIn today’s rapidly evolving food industry, the role of food testing laboratories has never been more critical. Ensuring the safety, quality, and authenticity of food products is paramount, and this responsibility falls heavily on the shoulders of laboratory managers. The economics of food testing—encompassing everything from high-throughput pesticide screening to advanced research on alternative protein sources—plays a pivotal role in shaping the operational efficiency and financial health of these laboratories.
Six benefits of remote support every laboratory should know by Andrea Mueller | Biopharma, Blogs, Environmental / Industrial, Food / Beverage, Food and Beverage, Forensic, Instrument maintenance, Life Science Research, Optimizing Performance, Pharma, Service, Support, Technology, TrainingImagine having a tech expert at your fingertips to solve computer issues or a fitness trainer guiding you through workouts from the comfort of your home. In today’s fast-paced world, the ability to provide and receive service and support remotely is no longer a luxury but a necessity. Whether it’s troubleshooting a software issue, repairing a device, offering customer assistance, or enjoying the convenience of telehealth as a private individual, remote capabilities have revolutionized how businesses operate and how individuals get help
Advancing immunopeptidomics for pancreatic cancer research with ZT Scan DIA by Katherine Tran | Blogs, Life Science ResearchPancreatic cancer remains one of the most fatal types of cancer, and the rates of occurrences and mortalities continue to be on a global rise.1,2 Recent statistics have reported that the diagnosis of pancreatic cancer is the eighth most common type of cancer and...
Application of CGE in cell and gene therapy by Kerstin Pohl | Biopharma, BioPhase 8800 system, BlogsIn a recent webinar, available on demand, scientists Luiza Chrojan and Ryan Hylands from Pharmaron, provided insights into the deployment of capillary gel electrophoresis (CGE) within cell and gene therapy. Luiza and Ryan shared purity data on plasmids used for adeno-associated virus (AAV) manufacturing and data on AAV genome integrity, viral protein (VP) purity and VP ratios using the BioPhase 8800 system.
From exposure to discovery: How SWATH DIA can enhance our understanding of the exposome and its impact on health by Rebekah Sayers | Blogs, Life Science Research, ZenoTOF 7600 systemLast year, Technology Networks hosted two webinars that featured groundbreaking research utilizing SWATH DIA (data-independent acquisition) for exposomics and metabolomics. Researchers Dr. Vinicius Verri Hernandes from the University of Vienna and Dr. Cristina Balcells from Imperial College London (ICL) demonstrated how a DIA approach can be successfully implemented in small molecule analysis using the ZenoTOF 7600 system. Their innovative approaches highlight the potential of SWATH DIA to enhance the detection and analysis of chemical exposures and metabolites, paving the way for new insights into environmental health and disease mechanisms.
PFAS testing: 2024 in review and what to expect for 2025 by SCIEX Community | Blogs, Environmental / IndustrialFor as long as PFAS persist in the environment, there is no doubt they will persist in our conversations as environmental scientists. Globally, PFAS contamination has been detected in water supplies, soil and even in the blood of people and wildlife. Different countries are at various stages of addressing PFAS contamination and many governments have set regulatory limits and are working on assessing the extent of contamination, cleaning up affected sites and researching safer alternatives.
Inside the box: Acoustic ejection mass spectrometry for drug discovery by Kirsten Craven | Blogs, Discovery, Echo MS, Pharma, QA/QCOn average, it takes 10-15 years and 1-2 billion dollars to approve a new pharmaceutical for clinical use. Since approximately 90% of new drug candidates fail in clinical development, the ability to make early, informed and accurate decisions on the safety and efficacy of new hits and leads is key to increasing the chances of success.
Unveiling the power of ZT Scan DIA: Insights from Ludwig Sinn’s presentation at World HUPO Congress 2024 by Rebekah Sayers | Blogs, Life Science Research, Proteomics, ZenoTOF 7600 systemIn a recent presentation at the World HUPO Congress 2024, Ludwig Sinn from the Ralser lab shared exciting advancements in proteomics research, focusing on the innovative ZT Scan DIA acquisition modes developed in collaboration with SCIEX. Let us explore the key highlights and benefits of this innovative technology.
To Switch or Not to Switch? That is the Question. by Ashley Sage | Blogs, Environmental / Industrial, Food / BeverageWhy Polarity Switching Matters The BasicsIn today’s busy analytical laboratories, productivity and high sample throughput are constant demands. More samples need to be analyzed in a shorter timeframe. Laboratories must work to use equipment at its maximum capacity,...
Improving precision by SCIEX Community | Blogs, Technology Factors that affect the reproducibility of your assay As scientists, we know our experiments must be reproducible. Without it, there is always doubt as to whether our data interpretations and conclusions are truly sound. With LC-MS/MS quantitative methods, high...
30 years of LC-MS/MS innovation continues by Ashley Sage | Blogs, TechnologyIn 1989, the first commercial, dedicated Atmospheric Pressure Ionisation (API) tandem quadrupole mass spectrometry system was launched at the Pittsburgh Conference (PittCon) in Atlanta, Georgia (GA), USA. The API III, as it was called, was introduced to the analytical...
Drugs of Abuse Analysis: How LC-MS/MS Reduced Run Times by 66% and Tripled Throughput by SCIEX Community | Blogs, ForensicElevate Performance in Your Forensic Toxicology LabYou only need to skim through the United Nations World Drug Report 2018 to see that drug abuse is escalating. Associated with numerous medical, social, and legal problems, it comes as no surprise that ‘drugs of abuse’...
Same Pesticides, Same Risks, Different Standards by SCIEX Community | Blogs, Food / BeverageShould we be worried about our health because our produce contains pesticides? The answer very much depends on where in the world you live–or where your food comes from. When it comes to protecting people from harmful pesticide residues in food, standards around the...
3 Advantages of Clinical Mass Spectrometry by SCIEX Community | Blogs, ClinicalAre you thinking about replacing existing immunoassay technology with clinical mass spectrometry? Keep reading to discover how the 3 “S”s will help you make the decision. 1. How does sensitivity play a role? Many of the analytes measured in a clinical chemistry lab...
Detect the Signal, Not the Noise by SCIEX Community | Blogs, Technology Improving the specificity and selectivity of your assay Your LC-MS assay is only as good as its power to discern your target compound from everything else. Standards dissolved in clean solvents can make beautiful assays, but analytes in real-world samples can behave...
“There’s Nothing Wrong with a Little Bit of Mold.” WRONG! by SCIEX Community | Blogs, Food / BeverageHas anyone ever said to you, “There’s nothing wrong with a bit of mold”? No one likes to waste food, and it’s not unusual for people to scrape or pick mold off of foods before eating! Believe it or not, there’s guidance on foods that are (and are not) safe to eat if...
Top 4 reasons to try a SCIEX software subscription by SCIEX Community | Blogs, Software, TechnologyAre you avoiding a software upgrade because of the cost? Just subscribe, sit back, and relax. The majority of SCIEX software solutions are now available as subscription products. For a price that is only 40% of the perpetual license fee, you can get access to more...
Improving Patient Care Through Translational Mass Spectrometry by SCIEX Community | Blogs, ClinicalFeaturing: Wake Forest® Baptist Health Steven Wong, Ph.D., DABCC (TC), FACB, Past President AACC, Professor of Pathology, serves as Director of the Clinical Chemistry and Toxicology Core Laboratory and is Co-director of the Clinical and Translational Mass Spectrometry...
Software Licensing Comparison: Subscription or Perpetual? by SCIEX Community | Blogs, Software, Technology Are you confused by software licensing? Do you want to know the difference between a subscription and a perpetual license? In this blog, we compare both options and explain the value of each choice for your laboratory. Years ago, the perpetual license model was the...
Make the Leap from GC to LC-MS/MS by SCIEX Community | Blogs, Technology Choosing the best technique for your analysis can be tough. Should you go with gas chromatography/mass spectrometry (GC-MS) or liquid chromatography/tandem mass spectrometry (LC-MS/MS)? That’s the key question. That’s why we’re here to help. The Limitations of...
Why Mass Spectrometry for Your Clinical Lab? by SCIEX Community | Blogs, ClinicalAaron Hudson, VP/GM, Clinical Diagnostics, SCIEX Aaron Hudson is Vice President and General Manager, Clinical Diagnostics at SCIEX. Aaron has been with SCIEX for over 17 years, beginning as a Sales Representative, and holding various roles including Director Global...
Bad Leftovers: Antibiotic Residues in Food by SCIEX Community | Blogs, Food / BeverageWe know that antibiotics used to treat livestock can end up in the food we eat. Routine food testing labs are essential for detecting compounds, like these, that can be dangerous to our health. Antibiotic residues include both parent molecules and metabolites left...
Canada’s Focus on Cannabis Quality and Safety Intensifies by SCIEX Community | Blogs, Food / BeverageThe Second in a Three-Part Series Welcome to the second in a series of blogs from the cannabis team at SCIEX, designed to bring you up to speed and put you in the lead of the recently legalized cannabis market in Canada. In the first blog, we introduced the Cannabis...
Looking for Ethanol Metabolites and Barbiturates in Urine? Get the Fast and Sensitive ‘Two Bird, One Stone’ Method by SCIEX Community | Blogs, ForensicAlcohol is legal and widely available, but it is an intoxicating and addictive substance that can have harmful effects on the human mind and body. It reduces inhibitions and distorts judgment and rational decision making, making it the number one cause of criminal...
Sensitivity, It’s at the Very Heart of Who We Are by Christie Hunter | Blogs, Technology Walk into any modern pharmaceutical company these days, and you’ll likely find at least one if not many, SCIEX LC-MS/MS instruments. Assays for the detection and quantitation of small molecule drugs, metabolites, biotherapeutics, biomarkers, and many other analytes...
The Advantages of a Software Maintenance Agreement by SCIEX Community | Blogs, Software, TechnologyYou’ve bought your mass spectrometer. You’ve installed all your hardware. You’ve got your operating software set up. You’ve mastered your software workflow modules to optimize quantitative and qualitative data processing. That’s it, right? Even though your system is...
You’ve Edited the Gene. Now What? by SCIEX Community | Blogs, Life Science Research, ProteomicsProtein-Level Verification Without The Need For Antibodies Using SWATH® Acquisition. Fast, Comprehensive, and Highly Reproducible Although humans have been able to influence the traits of plants and animals for thousands of years through domestication and selective...
Environmental Scientists: Here’s Why You Should Consider Nominal Mass Spectrometry for Your Routine PFAS and Gen-X Testing in Drinking Water by Craig Butt | Blogs, Environmental / IndustrialHow are you feeling about PFAS regulation right now? If you’re like us, you probably find it hard to pinpoint one specific feeling. But if we took a look at the current state of affairs, we’d all probably agree that it’s a minefield of uncertainty. Under the Safe...