According to the American Clinical Laboratory Association, more than 7 billion clinical lab tests are performed in the U.S. every year. While mass spectrometry represents only a fraction of the clinical applications, there are a growing number of tests where mass...
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Maximize NPS analysis with accurate mass spectrometry
LC-MS/MS is a powerful analytical tool in forensic toxicology testing that can support a variety of testing regimes such as screening, confirmation and quantitative workflows. More specifically, analysis of NPS using LC-MS/MS provides many advantages, including the ability to reliably detect new drugs and their metabolites from a variety of biological matrices.
Unlock the benefits of nominal mass spectrometry for NPS analysis
The development of analytical methods for the detection and quantitation of drugs and metabolites in a range of biological matrices is a challenging process. Forensic toxicology labs need a reproducible and reliable methodology to ensure the robustness of the data and the quality of the results. They also need robust and sensitive instrumentation that can detect drugs at trace levels with high specificity, especially when it comes to novel psychoactive substances (NPS), which can be difficult to monitor and control.
What has the Echo® MS system done for the pharma industry? (And don’t just take our word for it!)
SCIEX was very proud to have an illustration of the Acoustic Ejection Mass Spectrometry (AEMS) technology that powers the Echo® MS system on the front cover of the Journal of the American Society for Mass Spectrometry in January 2023. The associated article—Ultrahigh-Throughput Intact Protein Analysis with Acoustic Ejection Mass Spectrometry—was co-authored by scientists from SCIEX and Merck.
Back to the new basics: Part 1 | Making the leap from GC-MS to LC-MS
Producing accurate results quickly in a demanding environment is no easy feat for analytical scientists. What’s more, many of us are constantly questioning ourselves—I certainly am—about whether we are employing the best technique for the analysis at hand.
It’s an overwhelming thought, considering the wide range of tools that are available to choose from, each of which offers varying levels of capacity, sensitivity, selectivity, specificity and cost. How do you meet the unique needs of your organization without breaking the bank? I get it, and I’m not here to convince you it’s easy. My aim is to guide you through the process to help you make the right decision for you.
How does automatic calibration work on the QTOF, TripleTOF and ZenoTOF systems?
When you think about calibration of a mass spectrometer, there are actually two aspects to consider. There is the accuracy of the calibration (that it is correct when calibration is performed) and the stability or precision of the mass calibration (that it remains...
What is SWATH acquisition and what are the critical acquisition attributes?
In data-independent acquisition strategies like SWATH acquisition, an expanded mass isolation window is stepped across a mass range covering the mass-to-charge (m/z) distribution of peptides and a full scan MS/MS spectrum is collected at each step. Post-acquisition,...
Controlling the M5 MicroLC system with SCIEX OS software using contact closure
Contact closure can be used to control external devices that are not directly controlled by SCIEX OS software. A sample batch is first created in the SCIEX OS software for MS acquisition, and then a similar batch is created on an external LC device with the required...
The risky business of aflatoxins in milk
If you’re in the dairy or food testing business, you know the threat aflatoxins pose. Aflatoxins are a type of mycotoxin produced by Aspergillus parasiticus, aspergillus flavus , and rarely aspergillus nomius.1 These are likely the most extensively researched group of mycotoxins because of their adverse health effects.2 What’s more, they are widely found in a variety of crops, namely maize, tree nuts, and spices. Believed to be primarily caused by rising temperatures and humidity, these naturally occurring fungi grow on crops in the field, or during storage of feed and raw materials, where they can potentially produce toxins that enter the food chain.
Intabio acquisition expands SCIEX portfolio of impactful solutions to accelerate biotherapeutic development
Due to the nature of their production, biotherapeutics are difficult to manufacture. Growth conditions, purification protocols and formulation requirements can introduce unintended modifications into the protein structure that may affect its efficacy and safety.
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
How You Can Detect Pesticide 1080 In Milk & Infant Formula – A Poster Talk
In this poster talk André Schreiber, Applications and Product Manager for Food and Environmental Markets at SCIEX guides you through a new method developed in conjunction with Association of Analytical Communities (AOAC). The method is designed to better detect a harmful substance that the infant formula and milk industry are under threat from – Sodium Fluoroacetate, otherwise known as Compound 1080 or Monofluoroacetate.
Drug Metabolism and Bioanalysis Journal Articles Focus on Drug Metabolism and so Much More
Check-out the top articles that focus on innovations in drug metabolism as well as small molecule quantitation and biologics bioanalysis. Exciting advancements! We can’t wait to see all that will come in 2016! Quantitative analysis of maytansinoid (DM1) in human serum...
Reasons why LC-MS/MS is my method of choice for meat speciation and authenticity testing
The meat trade hasn’t had a good reputation since the horsemeat scandal that burst into headlines in 2013. The scandal has left such a mark that meat speciation, adulteration and authenticity are still high-profile topics today. Think about it from a...
Purchasing Mass Spec Technology for Your Forensic Lab
What does every scientist think about in the lab? Validation. This is the feeling I encountered while reading a recent scientific report on nature.com. What struck me was not only the study itself which discounted cannabinoid incorporation into hair as a method for...
A Reliable Method for the Identification, Quantitation, and Confirmation of Pesticides
When carrying out routine pesticide identification tests in your lab how simple is the process of identification, quantitation, and final confirmation from sample to sample? A reliable method designed to generate multiple data sets and confirm sample data in parallel with your test can save an awful lot of time and effort which is especially helpful as the demand for routine testing increases. In this poster talk, Detlev Schleuder, Support Manager for Food & Environmental Markets, explains how the new QTRAP® 6500+ system can optimize your laboratory’s output with this simple method.
The Gluten Free Cookie Label Test
I am a label reader. I like to eat healthily and know what the long, confusing ingredients on the side of a package mean. Therefore, in the spirit of the holiday season, I dedicate this blog to all the gluten intolerant folks out there whose only wish is to eat a yummy cookie while also being absolutely positively sure it is gluten free.
Testing Liquor for Authenticity Using LC-MS/MS Technology
The Proof is in Your Holiday Drink If you think bootlegging was limited to the age of Prohibition then you have never tested liquor for authenticity using mass spectrometry. Maybe it is a scientist thing, but we simply cannot help but bring up the subject as people...
Five Tips for Safe Handling Holiday Decorations
Bring out the boxes of decorations this holiday season and while you are at it, keep in mind you could be facing dangerous exposure to chemicals too. From trees to garland, candles and toys, here are some tips to keep in mind for safe handling. Trees Fake trees are...
Gain New Insights Into Human Spermatogenesis with this “Click & Easy” OneOmics Workflow
A recent webcast by Charles Pineau, Director of Protim, IRSET, Rennes, France, demonstrates how you can use the OneOmics™ Platform as a "Click & Easy" workflow for integrating next-generation proteomics (NGP) data with next-generation sequencing (NGS) data. Dr....
Thanksgiving Menu: A Detectable Feast!
On Thursday 26th November 2015, millions of households across the United States will sit down to a hearty traditional Thanksgiving meal. The Thanksgiving holiday is when people celebrate the blessings of the year, in particular the harvest.
Are there Antibiotics in your Thanksgiving Turkey?
Truth – the first turkey I ever cooked was still frozen when it hit our plates. I couldn’t figure out why that thing was taking so long to roast. Then it hit me. I forgot to defrost the bird. If I recall correctly, even the giblets were still in it. It was ten p.m. when I broke the news to my guests that the turkey was not happening. A pizza was ordered, and everyone breathed a sigh of relief that they would not be suffering from a bout of food poisoning.
Celebrate with a Pesticide Free Thanksgiving!
Before you start wondering if you should buy organic ingredients this Thanksgiving, it is good to know regulating bodies set and monitor allowable pesticide limits within our food supply. Pesticides that help control pests, disease, and deter unwanted animals from eating supplies found in fields, mills, and facilities. How and when this testing takes place in the United States is overseen by the Environmental Protection Agency (EPA) according to five primary regulating statutes.
Keeping Up with Synthetic Cannabinoids Using Mass Spec
Facts about Synthetic Cannabinoids and why you need to pay attention to evolving science
Mass Spectrometry Helps Researchers Solve a Mystery about Type 2 Diabetes Drug
This is an article from November 21, 2013. We thought it was an interesting story to share with you on this World Diabetes Day.
For the research conducted by the Australian and Canadian researchers, the analysis at the molecular level was optimized on SCIEX instrumentation, including the SCIEX TripleTOF® 5600 and the SCIEX QTRAP® 5500 system
Top Three Ways SCIEX has fun with Halloween Candy
Halloween is the time for lots of trick or treats ranging from chocolate bars to lollipops and oh so good candy corn. However, come October 31, it is time to mind sneaky ingredients that have the best disguise of all. From pork extracts, artificial sweeteners, to stuff that is hard to pronounce, SCIEX digs up some of our recent Food and Beverage studies for some ghoulishly good fun.
The Top Ten Things Scientists Think about on Halloween
The Top Ten Things Scientists Think about on Halloween
Analyze Large Omic Data Sets with Cloud Computing and See What More You Can Accomplish
Our scientific world is expanding. With each passing day, new discoveries are made, old discoveries are verified, and more data are generated. Large data sets are now the norm for omics experiments such as genomics, transcriptomics, proteomics, and metabolomics....
Simultaneous Detection of Multiple Species in Meat Using LC-MS/MS Technology
Smart food shopping starts with labels. However, what if we told you the ingredient list may not be all that it seems? According to Food Safety News, producers are sneaking lower quality ingredients into our food to save money. This type of food fraud is estimated to cost the global food industry $10 to $15 billion per year. If you think back to the Middle Ages, even our ancestors were consumed with cost savings by inserting nutshells, seeds, berries, and more within their spices.
Using Mass Spectrometry to Screen Hundreds of Known and Unknown Metabolites
In the field of metabolomics, you typically choose to identify and characterize as many compounds as possible in an unbiased fashion, or screen for a specific set of compounds that are biologically relevant to your research. The beauty of the TripleTOF® System is that...
MultiOmics Research For the Study of Placental Development
A recent study by Katy Williams (UCSF), Christie Hunter (SCIEX), and Andrew Olsen (Advaita) used the iPathwayGuide within the OneOmics cloud computing environment to help understand how placental development can go awry during certain pregnancy complications such as pre-eclampsia.