There are over 7,000 genetic diseases that could potentially be cured using gene therapy. Rare metabolic diseases, autoimmune disorders, cardiovascular disease and cancers are some of the top disease classes that can be addressed with gene therapies. With over 1,000...
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New features in OneOmics suite
I just wanted to thank the readers here, both the OneOmics suite users who’ve shared their time and watched OneOmics grow, and for all the talented developers and scientists who’ve made OneOmics suite what it is today.
Assess the performance of the Echo® MS system
To obtain the best, most reproducible results using the Echo MS system, it is important to select the best solvent for your analyte and matrix and to ensure the flow rate is optimized for your solvent. Please review this flow rate optimization community post to...
Merging two FASTA files
There is an easy way to merge two FASTA files together. Open notepad and type this string: type %*>"newfile.fasta" Enter any name for the FASTA file between the quotes. Save the file as: Merge FASTA files.bat Copy the two files you want to merge into the same...
Intabio acquisition expands SCIEX portfolio of impactful solutions to accelerate biotherapeutic development
Due to the nature of their production, biotherapeutics are difficult to manufacture. Growth conditions, purification protocols and formulation requirements can introduce unintended modifications into the protein structure that may affect its efficacy and safety.
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
Importing acquisition methods from Analyst software to SCIEX OS software
The SCIEX Triple Quad 7500 system is the first nominal mass instrument to be released completely on SCIEX OS software. Moving to a new software solution can be time consuming with the need to transfer numerous methods to the new platform. SCIEX OS software helps...
The honey sting
As a consumer it’s hard for me not to feel inundated with claims that our food is “all-natural” or “chemical-free” or that we should buy certain “superfoods” for their health benefits. We read labels and trust that the product we are buying is what we are truly...
Innovation that’s blasting through limitations in explosive detection
Mass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
A new generation of therapeutic modalities
There are over 7,000 genetic diseases that could potentially be cured using gene therapy. Rare metabolic diseases, autoimmune disorders, cardiovascular disease and cancers are some of the top disease classes that can be addressed with gene therapies. With over 1,000...
Enhancing Biologics with CESI-MS Characterization
Comprehensive characterization of a biologic requires analysis at both the intact and digest levels, but these analyses can be complex and cumbersome. For example, with conventional liquid chromatography separations, researchers are often left with limited information...
Top 5 Analytical Challenges for Pesticides in Cannabis
Now that cannabis is legalized in a majority of the United States and Canada, new regulations to help protect consumers lead us to an important question: What are they getting? Here, we'll help provide the answer. Image source: Shayanne Gal/Business Insider Some of...
To Switch or Not to Switch? That is the Question.
Why Polarity Switching Matters The BasicsIn today’s busy analytical laboratories, productivity and high sample throughput are constant demands. More samples need to be analyzed in a shorter timeframe. Laboratories must work to use equipment at its maximum capacity,...
Improving precision
Factors that affect the reproducibility of your assay As scientists, we know our experiments must be reproducible. Without it, there is always doubt as to whether our data interpretations and conclusions are truly sound. With LC-MS/MS quantitative methods, high...
30 years of LC-MS/MS innovation continues
In 1989, the first commercial, dedicated Atmospheric Pressure Ionisation (API) tandem quadrupole mass spectrometry system was launched at the Pittsburgh Conference (PittCon) in Atlanta, Georgia (GA), USA. The API III, as it was called, was introduced to the analytical...
Drugs of Abuse Analysis: How LC-MS/MS Reduced Run Times by 66% and Tripled Throughput
Elevate Performance in Your Forensic Toxicology LabYou only need to skim through the United Nations World Drug Report 2018 to see that drug abuse is escalating. Associated with numerous medical, social, and legal problems, it comes as no surprise that ‘drugs of abuse’...
Same Pesticides, Same Risks, Different Standards
Should we be worried about our health because our produce contains pesticides? The answer very much depends on where in the world you live–or where your food comes from. When it comes to protecting people from harmful pesticide residues in food, standards around the...
3 Advantages of Clinical Mass Spectrometry
Are you thinking about replacing existing immunoassay technology with clinical mass spectrometry? Keep reading to discover how the 3 “S”s will help you make the decision. 1. How does sensitivity play a role? Many of the analytes measured in a clinical chemistry lab...
“There’s Nothing Wrong with a Little Bit of Mold.” WRONG!
Has anyone ever said to you, “There’s nothing wrong with a bit of mold”? No one likes to waste food, and it’s not unusual for people to scrape or pick mold off of foods before eating! Believe it or not, there’s guidance on foods that are (and are not) safe to eat if...
Top 4 reasons to try a SCIEX software subscription
Are you avoiding a software upgrade because of the cost? Just subscribe, sit back, and relax. The majority of SCIEX software solutions are now available as subscription products. For a price that is only 40% of the perpetual license fee, you can get access to more...
Improving Patient Care Through Translational Mass Spectrometry
Featuring: Wake Forest® Baptist Health Steven Wong, Ph.D., DABCC (TC), FACB, Past President AACC, Professor of Pathology, serves as Director of the Clinical Chemistry and Toxicology Core Laboratory and is Co-director of the Clinical and Translational Mass Spectrometry...
Why Mass Spectrometry for Your Clinical Lab?
Aaron Hudson, VP/GM, Clinical Diagnostics, SCIEX Aaron Hudson is Vice President and General Manager, Clinical Diagnostics at SCIEX. Aaron has been with SCIEX for over 17 years, beginning as a Sales Representative, and holding various roles including Director Global...
Bad Leftovers: Antibiotic Residues in Food
We know that antibiotics used to treat livestock can end up in the food we eat. Routine food testing labs are essential for detecting compounds, like these, that can be dangerous to our health. Antibiotic residues include both parent molecules and metabolites left...
Canada’s Focus on Cannabis Quality and Safety Intensifies
The Second in a Three-Part Series Welcome to the second in a series of blogs from the cannabis team at SCIEX, designed to bring you up to speed and put you in the lead of the recently legalized cannabis market in Canada. In the first blog, we introduced the Cannabis...
Looking for Ethanol Metabolites and Barbiturates in Urine? Get the Fast and Sensitive ‘Two Bird, One Stone’ Method
Alcohol is legal and widely available, but it is an intoxicating and addictive substance that can have harmful effects on the human mind and body. It reduces inhibitions and distorts judgment and rational decision making, making it the number one cause of criminal...
The Advantages of a Software Maintenance Agreement
You’ve bought your mass spectrometer. You’ve installed all your hardware. You’ve got your operating software set up. You’ve mastered your software workflow modules to optimize quantitative and qualitative data processing. That’s it, right? Even though your system is...
You’ve Edited the Gene. Now What?
Protein-Level Verification Without The Need For Antibodies Using SWATH® Acquisition. Fast, Comprehensive, and Highly Reproducible Although humans have been able to influence the traits of plants and animals for thousands of years through domestication and selective...
Environmental Scientists: Here’s Why You Should Consider Nominal Mass Spectrometry for Your Routine PFAS and Gen-X Testing in Drinking Water
How are you feeling about PFAS regulation right now? If you’re like us, you probably find it hard to pinpoint one specific feeling. But if we took a look at the current state of affairs, we’d all probably agree that it’s a minefield of uncertainty. Under the Safe...
Trailblazers: Oscar Cabrices on Food Testing Trends to Watch for in the Americas
With the rapid shift in diet consciousness and environmental concerns, and the emergence of new technology, it’s a new food world. As a result, food testers are beginning to have a greater need for rigorous food testing techniques to ensure food safety and quality....
Why Quant?
Every decision you make requires a number As a pharmaceutical scientist, you understand the challenges in getting a new drug through the discovery and development pipeline. As an innovation partner in mass spectrometry, SCIEX works continuously with you, our...
6 Tips to Keep Your Lab’s Software Up and Running
6 Tips to Keep Your Lab’s Software Up and Running Is your lab utilizing SCIEX instrumentation but hesitant about upgrading to the latest software release? Perhaps you are uncertain about key features, error codes, or output. Not to worry, behind every great mass...