Advances in today’s technology have resulted in a need for higher and faster sample throughput, with increasing number of measured analytes per sample. The new SCIEX OS-MQ software breaks the routine and takes quantitation workflows to a new level. Key features...
Tags
Selecting an LC-MS system for quantitation of pharmaceutical drug development
We understand you are busy, needing to prioritize running instruments, reporting results and managing your laboratory to meet deadlines. We created a solution guide to explain how SCIEX systems fit in the drug development pipeline to save you time evaluating options.
Nitrosamines: Where are we now?
Nitrosamines are a large group of N-nitroso compounds that share a common functional N-N=O group. They are produced by a chemical reaction between a nitrosating agent and a secondary or tertiary amine. Back in 2018, nitrosamines suddenly found themselves in the spotlight when they were unexpectedly detected in medications for high blood pressure. Since then, they have been found in several other prescription medications, including those for heartburn, acid reflux and diabetes, resulting in manufacturers recalling some common medications.
Guide decisions during cell line development with more information at the intact level
Monitoring product quality attributes (PQAs) throughout monoclonal antibody (mAb) development is vital to ensuring drug safety and efficacy. By adopting orthogonal analytical techniques and integrating new technologies that have the potential to provide more information, it is possible to improve product quality and manufacturing efficiency and make more informed decisions.
High complexity of the lipidome
The complexity of the lipidome is diverse in the structure and there are many combinatorial isoforms that are available within nature. Currently, many different techniques are required to fully characterize a lipid molecule. What if you could do it in a single...
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
The honey sting
As a consumer it’s hard for me not to feel inundated with claims that our food is “all-natural” or “chemical-free” or that we should buy certain “superfoods” for their health benefits. We read labels and trust that the product we are buying is what we are truly...
Innovation that’s blasting through limitations in explosive detection
Mass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
A new generation of therapeutic modalities
There are over 7,000 genetic diseases that could potentially be cured using gene therapy. Rare metabolic diseases, autoimmune disorders, cardiovascular disease and cancers are some of the top disease classes that can be addressed with gene therapies. With over 1,000...
Enhancing Biologics with CESI-MS Characterization
Comprehensive characterization of a biologic requires analysis at both the intact and digest levels, but these analyses can be complex and cumbersome. For example, with conventional liquid chromatography separations, researchers are often left with limited information...
Full, partial and empty capsid ratios for AAV analysis: What’s the big deal?
For many of you working to develop gene therapy drugs, you know that the time to market the drug is critical. Because gene therapeutics cure diseases by targeting specific genes, it is a constant race to see who develops the drug first. Unlike other classes of drugs where multiple medications can be used to treat a disease, whoever is first to develop a gene therapy drug wins.
Using Mass Spectrometry to Identify and Quantify Contaminants in Water Samples
Access to clean wholesome water is one of our basic human rights. Human engineering has designed incredible methods to collect, filter, purify, store and distribute water to billions of us worldwide, but does this mean that our water is completely safe to drink? Also,...
LC-MS/MS Method for Biotherapeutic Drug Development Challenges
Traditionally, the pharmacokinetic profile of biotherapeutics such as insulin glargine, adalimumab, trastuzumab and others, used gold standard LBAs to assess dose-response during drug discovery and development. However, LBAs require a specific antibody reagent to be developed for each mAb variant, a process that is often incompatible with the compressed timeframes encountered during the initial stages of drug development.
QTOF Technology for Targeted and Unknown Forensic Drugs Screening Workflows
In this study, the Wisconsin State Laboratory of Hygiene (WSLH) outlines the comparison of their existing technology and how SCIEX LC-MS/MS systems can assist them in their forensic research. The WSLH routinely analyze for 300 forensic drug compounds in over 18,000 samples per year.
Expert Advice to Help You with Routine Food Testing in the Lab
Between 3-6 November 2015, the Recent Advances in Food Analysis (RAFA) 2015 Symposium took place in Prague, Czech Republic.
Contaminants and Novel Approaches in Food Analysis
During RAFA 2015, New Food Magazine hosted a roundtable (sponsored by SCIEX) to bring together experts with routine food testing backgrounds to discuss the latest industry trends, challenges, recent technological advances, and expectations of future laboratories.
Polar Pesticide Analysis by CESI-MS for Routine Food Testing – A Poster Talk
Method development for routine food testing presents many challenges – whether you are looking to increase the speed of your screening or simplify your method there can be different solutions suited to the task at hand. During RAFA 2015 in Prague, Steve Lock, Market Development Manager for SCIEX Separations in EMEA outlines how CESI-MS may be best suited for polar pesticide analysis.
Using Mass Spectrometry to Detect Trace Ingredients in Food – a Poster Talk
In today’s poster talk Jens Dahlmann, Senior Applications Specialist at SCIEX discusses how mass spectrometry might be best suited to the identification of trace ingredients in foods.
How You Can Detect Pesticide 1080 In Milk & Infant Formula – A Poster Talk
In this poster talk André Schreiber, Applications and Product Manager for Food and Environmental Markets at SCIEX guides you through a new method developed in conjunction with Association of Analytical Communities (AOAC). The method is designed to better detect a harmful substance that the infant formula and milk industry are under threat from – Sodium Fluoroacetate, otherwise known as Compound 1080 or Monofluoroacetate.
Drug Metabolism and Bioanalysis Journal Articles Focus on Drug Metabolism and so Much More
Check-out the top articles that focus on innovations in drug metabolism as well as small molecule quantitation and biologics bioanalysis. Exciting advancements! We can’t wait to see all that will come in 2016! Quantitative analysis of maytansinoid (DM1) in human serum...
Reasons why LC-MS/MS is my method of choice for meat speciation and authenticity testing
The meat trade hasn’t had a good reputation since the horsemeat scandal that burst into headlines in 2013. The scandal has left such a mark that meat speciation, adulteration and authenticity are still high-profile topics today. Think about it from a...
Purchasing Mass Spec Technology for Your Forensic Lab
What does every scientist think about in the lab? Validation. This is the feeling I encountered while reading a recent scientific report on nature.com. What struck me was not only the study itself which discounted cannabinoid incorporation into hair as a method for...
A Reliable Method for the Identification, Quantitation, and Confirmation of Pesticides
When carrying out routine pesticide identification tests in your lab how simple is the process of identification, quantitation, and final confirmation from sample to sample? A reliable method designed to generate multiple data sets and confirm sample data in parallel with your test can save an awful lot of time and effort which is especially helpful as the demand for routine testing increases. In this poster talk, Detlev Schleuder, Support Manager for Food & Environmental Markets, explains how the new QTRAP® 6500+ system can optimize your laboratory’s output with this simple method.
The Gluten Free Cookie Label Test
I am a label reader. I like to eat healthily and know what the long, confusing ingredients on the side of a package mean. Therefore, in the spirit of the holiday season, I dedicate this blog to all the gluten intolerant folks out there whose only wish is to eat a yummy cookie while also being absolutely positively sure it is gluten free.
Testing Liquor for Authenticity Using LC-MS/MS Technology
The Proof is in Your Holiday Drink If you think bootlegging was limited to the age of Prohibition then you have never tested liquor for authenticity using mass spectrometry. Maybe it is a scientist thing, but we simply cannot help but bring up the subject as people...
Five Tips for Safe Handling Holiday Decorations
Bring out the boxes of decorations this holiday season and while you are at it, keep in mind you could be facing dangerous exposure to chemicals too. From trees to garland, candles and toys, here are some tips to keep in mind for safe handling. Trees Fake trees are...
Gain New Insights Into Human Spermatogenesis with this “Click & Easy” OneOmics Workflow
A recent webcast by Charles Pineau, Director of Protim, IRSET, Rennes, France, demonstrates how you can use the OneOmics™ Platform as a "Click & Easy" workflow for integrating next-generation proteomics (NGP) data with next-generation sequencing (NGS) data. Dr....
Thanksgiving Menu: A Detectable Feast!
On Thursday 26th November 2015, millions of households across the United States will sit down to a hearty traditional Thanksgiving meal. The Thanksgiving holiday is when people celebrate the blessings of the year, in particular the harvest.
Are there Antibiotics in your Thanksgiving Turkey?
Truth – the first turkey I ever cooked was still frozen when it hit our plates. I couldn’t figure out why that thing was taking so long to roast. Then it hit me. I forgot to defrost the bird. If I recall correctly, even the giblets were still in it. It was ten p.m. when I broke the news to my guests that the turkey was not happening. A pizza was ordered, and everyone breathed a sigh of relief that they would not be suffering from a bout of food poisoning.
Celebrate with a Pesticide Free Thanksgiving!
Before you start wondering if you should buy organic ingredients this Thanksgiving, it is good to know regulating bodies set and monitor allowable pesticide limits within our food supply. Pesticides that help control pests, disease, and deter unwanted animals from eating supplies found in fields, mills, and facilities. How and when this testing takes place in the United States is overseen by the Environmental Protection Agency (EPA) according to five primary regulating statutes.
Keeping Up with Synthetic Cannabinoids Using Mass Spec
Facts about Synthetic Cannabinoids and why you need to pay attention to evolving science