Answer: When it’s a QTRAP® In today’s modern and frenzied analytical laboratories, triple quadrupole mass spectrometers (MS) are the ‘workhorse,’ frontline instrument for carrying out quantitative assays from drug discovery to food safety. To get the best selectivity...
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Pharma perspectives: The influence of LC-MS innovation on drug development outsourcing
It is no secret that (bio)pharmaceutical research and development is complex, both scientific and regulatory processes. Working for a contract research organization and more recently for SCIEX has provided an interesting perspective on trends the market experiences that affect many of us.
Nitrosamines: Where are we now?
Nitrosamines are a large group of N-nitroso compounds that share a common functional N-N=O group. They are produced by a chemical reaction between a nitrosating agent and a secondary or tertiary amine. Back in 2018, nitrosamines suddenly found themselves in the spotlight when they were unexpectedly detected in medications for high blood pressure. Since then, they have been found in several other prescription medications, including those for heartburn, acid reflux and diabetes, resulting in manufacturers recalling some common medications.
Easy switching of sources and LC flow regimes on the ZenoTOF 7600 system
This series of videos outlines how a user can easily switch sources and operate the system in different LC flow regimes.
Thailand cannabis legalization
Thailand has become the first southeast Asian country to legalize cannabis for medical use. Cannabis was originally introduced into Thailand from India, and until it was outlawed in the 1930s, it was historically used as a kitchen condiment, medicine and source of fiber.
Uploading and using transcriptomics data in the OneOmics suite
RNA experiments can be created in the OneOmics suite for multi-omics analyses, enabling integration of transcriptomics data and proteomics data for biological insight. To build RNA experiments, either CloudConnect for PeakView software 2.2 or BaseSpace (Illumina) can...
Downloading results from SCIEX Data Store or BaseSpace
Once your data processing sessions have completed, the results files are saved back to either SCIEX Data Store or BaseSpace. These can be downloaded from the cloud to your desktop for additional analysis. Please see these community posts to learn more: Explaining the...
Breaking down the SCIEX Triple Quad™ 7500 LC-MS/MS System – QTRAP® Ready
Sensitivity and robustness carry different meanings in the world of mass spectrometry. Generally, sensitivity refers to an instrument’s ability to achieve lower limits of detection (LOD). Robustness, on the other hand, refers to an instrument’s ability to consistently...
The honey sting
As a consumer it’s hard for me not to feel inundated with claims that our food is “all-natural” or “chemical-free” or that we should buy certain “superfoods” for their health benefits. We read labels and trust that the product we are buying is what we are truly...
The top 5 questions to ask when investing in accurate mass technology for forensic toxicology workflows
Are you considering the purchase of a high-resolution accurate mass (HRAM) instrument for your forensic toxicology lab? To help ensure you invest in a solution that ideally meets your needs, ask yourself the following key questions. 1. How do I ensure my results...
Innovation that’s blasting through limitations in explosive detection
Mass spectrometry’s important role in identifying explosives The need for rapid explosive detection is now an unfortunate reality. The remit is multifaceted. The first is for preventative purposes, to protect us from any threat to life. The second is in the...
Take 5 with Dan Blake – 5 Minutes, 5 Questions on the World of Clinical Mass Spec
We would like to formally (or informally) introduce the new SCIEX Clinical Diagnostics blog series entitled, Take 5. Every couple of months we will ask a member of our team to answer five questions and share their responses in a format you can read in five minutes. We...
The Technology Behind Safe, Legal Cannabis
The Third in a Three-Part Series Part 1: Cannabis is Legal in Canada - How Did We Get Here? Part 2: Canada's Focus on Cannabis Quality and Safety Intensifies Welcome to the third in a series of blogs from the cannabis team at SCIEX, designed to bring you up to speed...
What is Multi Attribute Methodology (MAM)?
Q&A with Sean McCarthy Global Market Manager, Biologics, SCIEX MAM is an acronym for Multiple Attribute Method. In short, MAM is a method which may be applied for characterization of a biotherapeutic to understand its sequence, identify liabilities, identify...
New Methods for N-Glycan Sequencing Provide Structural Information in as Little as 1 Hour
As interest in N-glycan analysis grows within the biopharma industry, innovation continues allowing analyses to be done in less time with fewer and less tedious, sample preparation steps. One of these recent innovations was the release of the SCIEX Fast Glycan...
When Chiral Separation Turns Tricky: The Story Behind CESI-MS in Forensic Chiral Analysis
Against a backdrop of rapid growth, chirality plays a major role in the synthesis of drugs in both pharmaceutical and illicit drug development. In fact, more than half of the drugs currently in use are chiral compounds, available as either racemates or pure...
Cannabis is Legal in Canada – How Did We Get Here?
The First in a Three-Part Series Welcome to the first in a series of blogs from the cannabis team at SCIEX, designed to bring you up to speed and put you in the lead of the recently legalized cannabis market in Canada. The Canadian cannabis market has taken the plunge...
Pathway to Success: Young Metabolomics Researchers Named in The Analytical Scientist’s Power List
The direct correlation of the metabolome to the phenotype means metabolomics is one of the most sought-after approaches for the study of disease and wellness, yet the separation, detection, quantification, and unambiguous identification of a chemically diverse...
3 Dicamba Analysis Questions You Need to Ask Yourself Today
We blinked and the last two years went in a flash. It seems like just yesterday, the Dicamba herbicide controversy hit the headlines in 2016 and the EPA set the regulations to expire in two years. Fast forward to today. Dicamba is an acid herbicide used to kill...
Don’t Be a Food Scandal Scapegoat. Fight Back with LC-MS/MS for Your Meat Authenticity Testing
The infamous horsemeat scandal of 2013 shined a spotlight on the questionable integrity of our meat supply. What followed was a lengthy investigation as the extent of the scandal unraveled before our eyes, reaching far beyond the European borders...
It’s Time to Turn Things Around―Faster and Accurate Mass Analysis of Organic Explosives
Sadly, the world is a volatile place. The threat of organic explosive use by terrorists and criminals is very much with us, posing a significant danger to people worldwide. The rising concern for public safety is a top priority for national security organizations...
Push Your Research to the Cutting Edge: 2018 Global CESI-MS Symposium
There are a lot of conferences vying for your attention every year. The Global CESI-MS Symposium on October 10-11 in the Netherlands is one you can’t afford to miss. It is the place to hear about the latest advancements made through the adoption of CESI-MS...
Break the routine: SCIEX OS-MQ improves your quantitation workflows
Advances in today’s technology have resulted in a need for higher and faster sample throughput, with increasing number of measured analytes per sample. The new SCIEX OS-MQ software breaks the routine and takes quantitation workflows to a new level. Key features...
Stop Fumbling Around in the Dark: Try LC-MS/MS for Designer Drugs in Forensic Samples
Imagine being blindfolded, sent into a large (dark) room filled with obstacles and challenged to find an item, but you don’t know what that item is, and you have never seen it before. Then you must do the same again the next day, but you are looking for a different...
Something’s in the Water: Tackle Your PFAS Analysis
Exposure to per- and polyfluoroalkyl substances (PFAS) residues could be dangerous. These chemicals have been linked to a variety of adverse health effects including liver damage, thyroid disease, decreased fertility, high cholesterol, obesity, hormone suppression,...
5 Reasons Why Mass Spec is Transforming Clinical Labs
According to the American Clinical Laboratory Association, more than 7 billion clinical lab tests are performed in the U.S. every year. While mass spectrometry represents only a fraction of the clinical applications, there are a growing number of tests where mass...
Save Effort. Save Time. Consolidate Your BioTherapeutic Quality, Safety, and Efficacy Assessments with One Direct LC-MS MAM Assay.
In a previous blog, we learned how you could Simplify Your Life with a Streamlined Workflow for Multiple Attribute Methodology (MAM). Based on the well-known technique of peptide mapping, a Liquid Chromatography-Mass Spectrometry-based MAM workflow (LC-MS MAM) enables...
Metabolism and Biotransformation – What Are You Missing?
Are you looking to improve your MetID studies? Want to achieve the productivity and throughput you need to keep your projects moving and have complete confidence that you’re not missing any low level or parent-like metabolites in your sample? In this blog, we’re...
Biologics Characterization: Intact and Subunit Mass Analysis
When All You Need Is Range – Mass Range, Dynamic Range, and the Complete Range Launching the best possible product in the shortest time possible is key for pharmaceutical companies like you. As you know, nearly every process throughout the biologics development cycle...
Now You Can Overcome Your Food and Environmental Testing Obstacles
How do you safeguard human health and protect your reputation through meeting stringent global food and environmental safety standards? When it comes to testing food and environmental samples, the quality of your testing data is vital to your business. You need fast...
Unraveling the Metabolome
Dr. David Wishart, Departments of Biological Sciences and Computing Science, University of AlbertaCanada’s TMIC is an internationally-recognized leader in metabolomics, providing tools and resources that are used by laboratories around the world. The center offers...